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Basic research on the use of postmortem MRI especially using spectroscopic data.

Research Project

Project/Area Number 20590690
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Legal medicine
Research InstitutionNippon Medical School

Principal Investigator

HIRAKAWA Keiko  Nippon Medical School, 医学部, 助教 (30165162)

Co-Investigator(Kenkyū-buntansha) KOIKE Kaoru  京都大学, 医学研究科, 教授 (10267164)
大野 曜吉  日本医科大学, 大学院・医学研究科, 教授 (70152220)
崔 范来  日本医科大学, 医学部, 助教 (60424751)
金涌 佳雅  日本医科大学, 大学院・医学研究科, 特別研究生 (80465343)
佐藤 格夫  日本医科大学, 医学部, 助教 (30409205)
Co-Investigator(Renkei-kenkyūsha) OHNO Youkichi  日本医科大学, 大学院・医学研究科, 教授 (70152220)
SAI Hanrai  日本医科大学, 医学部・, 助教 (60424751)
KANAWAKU Yoshim  防衛医科大学校, 医教育学部・医学科・専門課程, 助教 (80465343)
SATO Norio  日本医科大学, 医学部, 助教 (30409205)
ASUNO Tomohiko  日本医科大学, 医学部, 助教 (00318528)
Research Collaborator KURIBAYASHI Hideto  アジレント・テクノロジー株式会社ライフサイエンス部門, リサーチプロダクト営業部, MRI アプリケーションエンジニア
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
KeywordsMRI / 死後画像診断 / NMRスペクトル / メタボロミクス / 死後経過時間 / 温度画像 / 核磁気共鳴法 / 死後硬直 / 社会医学
Research Abstract

We studied on the use of postmortem MRI especially using spectroscopic data.Pattern recognition of spectra derived from ^1H NMR spectroscopy was used to investigate metabolic disturbances after death in the rat skeletal muscles and brain. NMR based metabolomic data may provide useful informations to estimate postmortem interval and to investigate the cause of death of the cadaver.Magnetic resonance imaging thermometry was newly introduced into measurement of temperature changes in cooling dead rats.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (24 results)

All 2010 2009 2008

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (19 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Pattern Recognition Analysis of Proton Nuclear Magnetic Resonance Spectra of Brain Tissue Extracts from Rats Anesthetized with Propofol or Isoflurane2010

    • Author(s)
      Kawaguchi H, Hirakawa K, Miyauchi K, Koike K, Ohno Y, Sakamoto A
    • Journal Title

      PLoS ONE 5(6)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pattern Recognition Analysis of Proton Nuclear Magnetic Resonance Spectra of Brain Tissue Extracts from Rats Anesthetized with Propofol or Isoflurane.2010

    • Author(s)
      Kawaguchi H, Hirakawa K, Miyauchi K, Koike K, Ohno Y, Sakamoto A
    • Journal Title

      PLoS ONE

      Volume: 5(6)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Experimental estimati on of postmortem interval using mult on ivariate analysis of proton NMR meta bolomic data2009

    • Author(s)
      Keiko Hirakawa, Kaoru Koike, Kyoko Uekusa, Makoto Nihira, Kohtaro Yuta, Youkichi Ohno
    • Journal Title

      Legal Medicine 11

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Experimental estimation of postmortem interval using multivariate analysis of proton NMR metabolomic data2009

    • Author(s)
      K.Hirakawa, K.Koike, K.Uekusa, M.Nihira, K.Yuta, Y.Ohno
    • Journal Title

      Legal Medicine 11

    • NAID

      10027262921

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 核磁気共鳴技術を用いた新しい医学検査と診断技法の開発2010

    • Author(s)
      平川慶子
    • Organizer
      イノベーション・ャパン2010
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report
  • [Presentation] NMRメタボロミクスを用いた麻酔薬のラット脳における作用2010

    • Author(s)
      宮内健佑
    • Organizer
      第17回日本静脈麻酔学会
    • Place of Presentation
      弘前
    • Related Report
      2010 Final Research Report
  • [Presentation] PATTERN RECOGNITION USING 1H-NMR OF THE INTESTINAL EPITHELIAL CELL (IEC-6) UNDER OXIDATIVE STRESS2010

    • Author(s)
      K Nakata
    • Organizer
      33rd Annual Conference on Shock (session ; P1)
    • Place of Presentation
      Portland
    • Related Report
      2010 Final Research Report
  • [Presentation] MRIを用いた死体内温度分布の実験的連続撮像2010

    • Author(s)
      金涌佳雅
    • Organizer
      第94次日本法医学会学術全国集会
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report
  • [Presentation] NMRメタボロミクスを用いたついて測定を行なった疾患解明システム-臨床応用をめざして2010

    • Author(s)
      平川慶子
    • Organizer
      第9回バイオテクノロジー国際会議
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report
  • [Presentation] The Use of MR Thermometry in Legal Medicine : A Feasibility Study utilizing Rat Rectal Temperature.2010

    • Author(s)
      栗林秀人
    • Organizer
      ISMRM-ESMRMB Joint Annual Meeting
    • Place of Presentation
      Stockholm
    • Related Report
      2010 Final Research Report
  • [Presentation] The Use of MR Thermometry in Legal Medicine ; A Feasibility Study utilizing Rat Rectal Temperature.2010

    • Author(s)
      平川慶子, 他4名
    • Organizer
      Joint Annual Meeting ISMRM-ESMRMB 2010
    • Place of Presentation
      Stockholm International Fairs & Congress Centre(Stockholm, Sweden)
    • Related Report
      2010 Annual Research Report
  • [Presentation] NMRメタボロミクスを用いた疾患解明システム-臨床応用をめざして-2010

    • Author(s)
      平川慶子
    • Organizer
      第9回バイオテクノロジー国際会議
    • Place of Presentation
      東京国際展示場(江東区、東京)
    • Related Report
      2010 Annual Research Report
  • [Presentation] MRIを用いた死体内温度分布の実験的連続撮像2010

    • Author(s)
      平川慶子, 他5名
    • Organizer
      第94次日本法医学会学術全国集会(東京)
    • Place of Presentation
      タワーホール船堀(江戸川区、東京)
    • Related Report
      2010 Annual Research Report
  • [Presentation] PATTERN RECOGNITION USING 1H-NMR OF THE INTESTINAL EPITHELIAL CELL(IEC-6)UNDER OXIDATIVE STRESS2010

    • Author(s)
      平川慶子, 他9名
    • Organizer
      33rd Annual Conference on Shock (Portland)
    • Place of Presentation
      Portland Marriott Down-town Waterfront (Oregon, USA)
    • Related Report
      2010 Annual Research Report
  • [Presentation] 核磁気共鳴技術を用いた新しい医学検査と診断技法の開発2010

    • Author(s)
      平川慶子
    • Organizer
      イノベーション・ジャパン2010
    • Place of Presentation
      東京国際フォーラム(千代田区、東京)
    • Related Report
      2010 Annual Research Report
  • [Presentation] 高磁場環境対応の高性能非磁性薬液注入装置の開発2009

    • Author(s)
      平川慶子, 森川秀行, 村木秀樹, 佐藤格夫, 小池薫, 増野智彦, 大野曜吉
    • Organizer
      第48回 NMR討論会
    • Place of Presentation
      九州大学医学部百年講堂(福岡県)
    • Year and Date
      2009-11-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] 高磁場環境対応の高性能非磁性薬液注入装置の開発2009

    • Author(s)
      平川慶子
    • Organizer
      イノベーションジャパン2009 新技術説明会
    • Place of Presentation
      東京国際フォーラム(東京都)
    • Year and Date
      2009-09-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] NMRメタボロミクスを用いた疾患解明システム-臨床応用をめざして-2009

    • Author(s)
      平川慶子
    • Organizer
      第8回国際バイオアカデミックフォーラム
    • Place of Presentation
      東京ビッグサイト(東京都)
    • Year and Date
      2009-06-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] 高磁場環境対応の高性能非磁性薬液注入装置の開発2009

    • Author(s)
      平川慶子
    • Organizer
      第48回NMR討論会
    • Place of Presentation
      福岡市
    • Related Report
      2010 Final Research Report
  • [Presentation] Experimental trial of the estimation of postmortem interval using multivariate analysis of proton NMR based metabolomic data.2008

    • Author(s)
      平川慶子
    • Organizer
      7th International Symposium ADVANCES IN LEGAL MEDICINE
    • Place of Presentation
      Osaka
    • Year and Date
      2008-09-03
    • Related Report
      2010 Final Research Report
  • [Presentation] Rectal temperature measurement in cooling dead rats using MR thermometry2008

    • Author(s)
      栗林秀人
    • Organizer
      7th International Symposiumラット骨格筋のin vivo 31P MRS MEDICINE
    • Place of Presentation
      Osaka
    • Year and Date
      2008-09-03
    • Related Report
      2010 Final Research Report
  • [Presentation] Experimental trial of the estimation of postmortem interval using multivariate analysis of proton NMR based metabolomic data.2008

    • Author(s)
      平川 慶子
    • Organizer
      7th International Symposium ADVANCES IN LEGAL MEDICINE
    • Place of Presentation
      大阪府Osaka Central Public Hall
    • Year and Date
      2008-09-03
    • Related Report
      2008 Annual Research Report
  • [Presentation] Rectal temperature measurement in cooling dead rats using MR thermometry2008

    • Author(s)
      栗林 秀人
    • Organizer
      7th International Symposium ADVANCES IN LEGAL MEDICINE
    • Place of Presentation
      大阪府Osaka Central Public Hall
    • Year and Date
      2008-09-03
    • Related Report
      2008 Annual Research Report
  • [Patent(Industrial Property Rights)] 薬液注入装置2009

    • Inventor(s)
      大野曜吉、平川慶子、増野智彦、佐藤格夫、森川秀行、村木秀樹
    • Industrial Property Rights Holder
      学校法人日本医科大学、(株)ユニフローズ
    • Industrial Property Number
      2009-143488
    • Filing Date
      2009-06-16
    • Related Report
      2010 Final Research Report 2009 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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