Elucidation of the pathogenesis of alcoholic pancreatitis and development of its prevention
| Project/Area Number |
20590802
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Tohoku University |
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Principal Investigator |
SATOH Akihiko Tohoku University, 大学院・医学系研究科, 非常勤講師 (70312569)
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| Co-Investigator(Kenkyū-buntansha) |
MASAMUNE Atsushi 東北大学, 病院, 助教 (90312579)
KUME Kiyoshi 東北大学, 大学院・医学系研究科, 非常勤講師 (30431563)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 膵炎 / アルコール / 線維化 / シグナル伝達 / 小胞体ストレス / 遺伝子多型 / CD14 / Toll-like recepto / Toll-like recetor / 細胞内シグナル / 急性膵炎 / 慢性膵炎 / 膵星細胞 |
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| Research Abstract |
Recent studies have suggested a role of endoplasmic reticulum (ER) stress in a variety of diseases. We here examined the activation of unfold protein response (UPR) in response to ER stresses. We showed that, in response to thapsigargin and tunicamycin, the expression of the binding protein (BiP) and the activation of protein kinase RNA-like ER kinase, eukaryotic initiation factor 2, and apoptosis-related transcription factor CHOP in isolated rat pancreatic acini.
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Report
(4 results)
Research Products
(32 results)
