Elucidation of the micro-RNA-mediated regulation of pancreatic stellate cell activation and its therapeutic applications.
| Project/Area Number |
20590803
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Tohoku University |
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Principal Investigator |
MASAMUNE Atsushi Tohoku University, 病院, 助教 (90312579)
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| Co-Investigator(Kenkyū-buntansha) |
SATOH Kennichi 東北大学, 病院, 講師 (10282055)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 膵炎 / 膵癌 / 線維化 / マイクロRNA / 上皮間葉転換 / 放射線治療 / 膵星細胞 / interleukin-33 / 慢性膵炎 / 膵線維化 |
|---|
| Research Abstract |
There is accumulating evidence that pancreatic stellate cells (PSCs) play a pivotal role in pancreatic fibrosis associated with chronic pancreatitis and pancreatic cancer. We compared microRNA expression profiles between freshly-isolated (quiescent) rat PSCs and culture-activated PSCs. We found that the expression of miR-100, miR-128, miR-143 was increased whereas that of miR-126 and miR-200 was decreased upon activation by culture in serum-containing medium. The functional consequences of these alternations are currently under investigation.
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Report
(4 results)
Research Products
(38 results)
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[Journal Article] The evaluation of MSX2 mRNA expression level in biliary brush cytological specimens.2011
Author(s)
Ito H, Satoh K, Hamada S, Hirota M, Kanno A, Ishida K, Unno J, Masamune A, Katayose Y, Unno M, Shimosegawa T.
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Journal Title
Anticancer Res. 31
Pages: 1011-1017
Related Report
Peer Reviewed
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[Journal Article] Calcium-binding protein S100P is a novel diagnostic marker of cholangiocarcinoma.2011
Author(s)
Hamada S, Satoh K, Hirota M, Kanno A, Ishida K, Umino J, Ito H, Kikuta K, Kume K, Masamune A, Katayose Y, Unno M, Shimosegawa T.
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Journal Title
Cancer Sci. 102
Pages: 150-156
NAID
Related Report
Peer Reviewed
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[Journal Article] LIV-1 enhances the aggressive phenotype through the induction of epithelial to mesenchymal transition in human pancreatic carcinoma cells.2009
Author(s)
Unno J, Satoh K, Hirota M, Kanno A, Hamada S, Ito H, Masamune A, Tsukamoto N, Motoi F, Egawa S, Unno M, Horii A, Shimosegawa T.
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Journal Title
Int J Oncol. 35
Pages: 813-821
Related Report
Peer Reviewed
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