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New therapy for diastolic heart failure from the standpoint of insulin resistance

Research Project

Project/Area Number 20590826
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionTottori University

Principal Investigator

OGINO Kazuhide  Tottori University, 医学部附属病院, 准教授 (70294311)

Co-Investigator(Kenkyū-buntansha) HISATOME Ichiro  鳥取大学, 医学(系)研究科(研究院), 教授 (60211504)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords糖代謝異常 / 拡張不全 / インスリン抵抗性 / インスリン抗性
Research Abstract

[Aim] (1) The effects of pioglitazone (PIO), benzbromarone (BENZ) and losartan (LOS) in CHF with insulin resistance (IR), (2) the effects of exercise and PIO in CHF mouse.
[Results] PIO, BENZ and LOS improved inflammatory cytokines and IR in CHF. Serum uric acid level and inflammatory cytokines were correlated with IR. In CHF mouse, both PIO and exercise improved IR and cardiac function with the reduction of inflammatory cytokines and matrix metalloproteinases (MMPs).
[Conclusion] There was relationship between IR and cardiac function in CHF, which may be mediated via inflammatory cytokines and MMPs.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (14 results)

All 2011 2010 2009 2008

All Journal Article (4 results) (of which Peer Reviewed: 2 results) Presentation (10 results)

  • [Journal Article] Addition of losartan to angiotensin-converting enzyme inhibitors improves insulin resistance in patients with chronic heart failure treated without ss-blockers.2011

    • Author(s)
      荻野和秀
    • Journal Title

      Circulation Journal

      Volume: 74 Pages: 2346-2352

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Addition of losartan to angiotensin- converting enzyme inhibitors improves insulin resistance in patients with chronic heart failure treated without β-blockers.2010

    • Author(s)
      Ogino K, Kato M, Furuse Y, Kinugasa Y, Kaetsu Y, Mizuta E, Sugihara S, Ishida K, Yanagihara K, Hisatome I, Shigemasa C.
    • Journal Title

      Circ J. 74

      Pages: 2346-2352

    • NAID

      10026972758

    • Related Report
      2010 Final Research Report
  • [Journal Article] Uric acid-lowering treatment with benzbromarone in patients with heart failure : a doubleblind placebo-controlled crossover preliminary study.2010

    • Author(s)
      Ogino K, Kato M, Furuse Y, Kinugasa Y, Ishida K, Osaki S, Kinugawa T, Igawa O, Hisatome I, Shigemasa C, Anker SD, Doehner W.
    • Journal Title

      Circ Heart Fail. Jan;3:

      Pages: 73-81

    • Related Report
      2010 Final Research Report
  • [Journal Article] Uric acid-lowering treatment with benzbromarone in patients with heart failure : A double blind placebo-controlled crossover preliminary study2010

    • Author(s)
      荻野和秀
    • Journal Title

      Circulation Heart Failure 3

      Pages: 73-81

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] The effects of losartan on insulin resistance in patients with chronic heart failure treated with ACE inhibitors2011

    • Author(s)
      荻野和秀
    • Organizer
      14^<th> International Symposium on Purine and Pyrimidine Metabolism in Man (PP11)
    • Place of Presentation
      東京、京王プラザホテル
    • Year and Date
      2011-02-19
    • Related Report
      2010 Annual Research Report
  • [Presentation] ACE阻害薬治療中の心不全におけるロサルタン追加投与のインスリン抵抗性に及ぼす影響2011

    • Author(s)
      荻野和秀
    • Organizer
      第44回日本痛風・核酸代謝学会学術集会
    • Place of Presentation
      東京、京王プラザホテル
    • Year and Date
      2011-02-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] ACE阻害薬治療中の心不全におけるロサルタン追加投与のインスリン抵抗性に及ぼす影響2011

    • Author(s)
      荻野和秀、水田栄之助、杉原志伸、柳原清孝、石田勝則、衣笠良治、古瀬祥之、加藤雅彦、浜田紀宏、重政千秋、山本康孝、久留一郎
    • Organizer
      第44回日本痛風核酸代謝学会
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report
  • [Presentation] The effects of losartan on insulin resistance in patients with chronic heart failure treated with ACE inhibitors.2011

    • Author(s)
      荻野和秀、水田栄之助、杉原志伸、柳原清孝、石田勝則、衣笠良治、古瀬祥之、加藤雅彦、浜田紀宏、重政千秋、山本康孝、久留一郎
    • Organizer
      プリン・ピリミジン代謝国際シンポジウム
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report
  • [Presentation] Matrix metalloproteinase were produced in failing hearts and were decreased with spironolactone in patients with chronic heart failure2009

    • Author(s)
      荻野和秀
    • Organizer
      ヨーロッパ心不全学会
    • Place of Presentation
      フランス・ニース
    • Year and Date
      2009-05-31
    • Related Report
      2009 Annual Research Report
  • [Presentation] Spironolactone, not Furosemide, Improved Insulin Resistance in Patients with Chronic Heart Failure2009

    • Author(s)
      荻野和秀
    • Organizer
      日本循環器学会
    • Place of Presentation
      大阪
    • Year and Date
      2009-03-21
    • Related Report
      2008 Annual Research Report
  • [Presentation] Matrix metalloproteinase were produced in failing hearts and were decreased with spironolactone in patients with chronic heart failure.2009

    • Author(s)
      荻野和秀、加藤雅彦、久留一郎、重政千秋
    • Organizer
      ヨーロッパ心不全学会
    • Place of Presentation
      ニース
    • Related Report
      2010 Final Research Report
  • [Presentation] Spironolactone, not furosemide, improved insulin resistance in patients with chronic heart failure.2009

    • Author(s)
      荻野和秀、加藤雅彦、久留一郎、重政千秋
    • Organizer
      日本循環器学会
    • Place of Presentation
      大阪
    • Related Report
      2010 Final Research Report
  • [Presentation] Matrix Metalloproteinases Were Produced in Failing Hearts and Were Decreased With Spironolactone in Patients With Chronic Heart Failure2008

    • Author(s)
      荻野和秀
    • Organizer
      アメリカ心不全学会
    • Place of Presentation
      カナダ・トロント
    • Year and Date
      2008-09-22
    • Related Report
      2008 Annual Research Report
  • [Presentation] Matrix metalloproteinases were produced in failing hearts and were decreased with spironolactone in patients with chronic heart failure.2008

    • Author(s)
      荻野和秀、加藤雅彦、久留一郎、重政千秋
    • Organizer
      アメリカ心不全学会
    • Place of Presentation
      トロント
    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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