Clarification of new mechanism of ischemic heart disease through periodontitis and identification of cause periodontitis bacterium

• Project/Area Number: 20590829
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Kumamoto University
• Principal Investigator: SOEJIMA Hirofumi Kumamoto University, 保健センター, 准教授 (80332881)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 歯周病スコア / 歯周病菌 / 冠動脈 / プラーク / mRNA / 冠動脈形成術 / 高感度c-reactive protein / 急性冠症候群 / バルーン / 炎症反応 / 歯周病 / 抗体価 / Toll-like receptor / 白血球 / 歯周病抗体価 / 冠動脈疾患

Research Abstract

The relativity of the periodontitis severity and high sensitivity c-reactive protein that was the index of the inflammatory reaction of the whole body was proven. A part of coronary plaque contents adheres to the balloon after the coronary intervention. The detection of the periodontitis bacterium was tried from this balloon adhesion thing by polymerase chain reaction, then, mRNA of Prevotella intermedia and Porphyromonas gingivalis was detected.

Research Products

• [Journal Article] Differential Effect of Low-Dose Aspirin for Primary Prevention of Atherosclerotic Events in Diabetic Management : A subanalysis of the JPAD Tria. (2011)
  • Author(s): Okada S, Soejima H.
  • Journal Title: Diabetes Care in Press
  • Peer Reviewed
• [Journal Article] Low-dose aspirin therapy in patients with type 2 diabetes and reduced glomerular filtration rate : subanalysis from the JPAD trial. (2011)
  • Author(s): Saito Y, Soejima H.
  • Journal Title: Diabetes Care 34 Pages: 280-285
  • Peer Reviewed
• [Journal Article] Low-dose aspirin therapy in patients with type 2 diabetes and reduced glomerular filtration rate : subanalysis from the JPAD trial (2011)
  • Author(s): Yoshihiko Saito
  • Journal Title: Diabetes Care Volume: VOL.34 Pages: 280-285
  • Peer Reviewed
• [Journal Article] Aspirin for the primary prevention of cardiovascular events in patients with peripheral artery disease or diabetes mellitus. Analyses from the JPAD, POPADAD and AAA trials. (2010)
  • Author(s): Soejima H, Morimoto T, Saito Y, Ogawa H.
  • Journal Title: Thrombosis and Haemostasis 104 Pages: 1085-1088
  • Peer Reviewed
• [Journal Article] Aspirin for the primary prevention of cardiovascular events in patients with peripheral artery disease or diabetes mellitus.Analyses from the JPAD, POPADAD and AAA trials (2010)
  • Author(s): Hirofumi Soejima
  • Journal Title: Thrombosis and Haemostasis Volume: VOL.104 Pages: 1085-1088
  • Peer Reviewed
• [Journal Article] Differences in oxidative stress markers based on the aetiology of heart failure : comparison of oxidative stress in patients with and without coronary artery disease. (2009)
  • Author(s): Nagayoshi Y, Soejima H.
  • Journal Title: Free Radical Research 43 Pages: 1159-1166
  • Peer Reviewed
• [Journal Article] High ratio of myeloid dendritic cells to plasmacytoid dendritic cells in blood of patients with acute coronary syndrome. (2009)
  • Author(s): Fukunaga T, Soejima H.
  • Journal Title: Circulation Journal 73 Pages: 1914-1919
  • NAID: 10025936326
  • Peer Reviewed
• [Journal Article] Expression levels of Toll-like receptor genes in coronary atherosclerotic lesions of patients with acute coronary syndrome or stable angina pectoris. (2009)
  • Author(s): Fukushima R, Soejima H.
  • Journal Title: Circulation Journal 73 Pages: 1479-1484
  • NAID: 10025933786
  • Peer Reviewed
• [Journal Article] Prevalence of changes in undiagnosed glucose intolerance according to age and gender in Japanese middle-aged working people. (2009)
  • Author(s): Kawano H, Soejima H.
  • Journal Title: Circulation Journal 73 Pages: 1062-1066
  • NAID: 10025931397
  • Peer Reviewed
• [Journal Article] Significant association between score of periodontal disease and coronary artery disease. (2009)
  • Author(s): Oe Y, Soejima H.
  • Journal Title: Heart and Vessels 24 Pages: 103-107
  • Peer Reviewed
• [Journal Article] Periodontal status and Prevotella intermedia antibody in acute coronary syndrome. (2009)
  • Author(s): Soejima H.
  • Journal Title: International Journal of Cardiology 137 Pages: 304-306
  • Peer Reviewed
• [Journal Article] Periodontal status and Prevotella intermedia antibody in acute coronary syndrome (2009)
  • Author(s): Hirofumi Soejima
  • Journal Title: International Journal of Cardiology 137 Pages: 304-306
  • Peer Reviewed
• [Journal Article] Expression levels of Toll-like receptor genes in coronary atherosclerotic lesions of patients with acute coronary syndrome or stable angina pectoris (2009)
  • Author(s): Ryuichiro Fukushima
  • Journal Title: Circulation Journal 73 Pages: 1479-1484
  • Peer Reviewed
• [Journal Article] High ratio of myeloid dendritic cells to plasmacytoid dendritic cells in blood of patients with acute coronary syndrome (2009)
  • Author(s): Takashi Fukunaga
  • Journal Title: Circulation Journal 73 Pages: 1914-1919
  • Peer Reviewed
• [Journal Article] Significant association between score of periodontal disease and coronary artery disease. (2009)
  • Author(s): Yoko Oe
  • Journal Title: Heart and Vessels 24 Pages: 103-107
  • Peer Reviewed
• [Journal Article] ehydroepiandrosterone levels vary according as heart failure condition in patients with idiopathic dilated cardiomyopathy. (2008)
  • Author(s): Kawano H Nagayoshi Y, Soejima H.
  • Journal Title: International Journal of Cardiology 125 Pages: 277-279
  • Peer Reviewed
• [Journal Article] B-type natriuretic peptide after hormone therapy in postmenopausal women with chest pain and normal coronary angiogram. (2008)
  • Author(s): Kawano H Nagayoshi Y, Soejima H.
  • Journal Title: Menopause 15 Pages: 352-356
  • Peer Reviewed
• [Journal Article] Periodontal status and Prevotella intermedia antibody in acute coronary syndrome. (2008)
  • Author(s): Hirofumi Soejima
  • Journal Title: International Journal of Cardiology (In press)
  • Peer Reviewed
• [Journal Article] Dehydroepiandrosterone levels vary according as heart failure condition in patients with idiopathic dilated cardiomyopathy. (2008)
  • Author(s): Hiroaki Kawano
  • Journal Title: International Journal of Cardiology 125 Pages: 277-279
  • Peer Reviewed
• [Presentation] Impact of blood pressure control in type 2 diabetes patients in relation to aspirin therapy : insight from the JPAD trial (2010)
  • Author(s): Hirofumi Soejima
  • Organizer: America Heart Association Scientific Sessions 2010
  • Place of Presentation: McCormic Place,Chicago, Illinois, USA
  • Year and Date: 2010-11-15
• [Presentation] Aspirin reduces the incidence of stroke events in poorly blood controlled patients with type 2 diabetes (2010)
  • Author(s): Hirofumi Soejima
  • Organizer: 74^<th> Annual Scientific Session of the Japanese Circulation Society
  • Place of Presentation: Kyoto International Conference Center, Kyoto
  • Year and Date: 2010-03-07
• [Presentation] Aspirin reduces the incidence of stroke events in poorly blood controlled patients with type 2 diabetes (2009)
  • Author(s): Hirofumi Soejima
  • Organizer: American Heart Association Scientific Sessions 2009
  • Place of Presentation: Orange County Convention Center, Orland, Florida, USA
  • Year and Date: 2009-11-17
• [Presentation] Serum IgG levels against Prevotella Intermadia are independently associated with acute coronary syndrome (2009)
  • Author(s): Yoko Oe
  • Organizer: 73^<th> Annual Scientific Session of the Japanese Circulation Society
  • Place of Presentation: Osaka International Convention Center, Osaka
  • Year and Date: 2009-03-22
• [Presentation] Serum IgG levels against prevotella intermedia are independently associated with acute coronary syndrome. (2009)
  • Author(s): Yoko Oe
  • Organizer: 日本循環器学会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2009-03-22
• [Presentation] Heart failure severity is indicated by circulating T cell osteopontin expression levels (2009)
  • Author(s): Hirofumi Soejima
  • Organizer: 73^<th> Annual Scientific Session of the Japanese Circulation Society
  • Place of Presentation: Osaka International Convention Center, Osaka
  • Year and Date: 2009-03-21
• [Presentation] Heightened expression of Toll-like receptor-4 gene expression in coronary atherosclerotic lesions in patients with acute coronary syndrome (2009)
  • Author(s): Ryuichiro Fukushima
  • Organizer: 73^<th> Annual Scientific Session of the Japanese Circulation Society
  • Place of Presentation: Osaka International Convention Center, Osaka
  • Year and Date: 2009-03-20
• [Presentation] Heart failure severity is indicated by circulating T cell osteopontin expression levels (2008)
  • Author(s): Hirofumi Soejima
  • Organizer: American Heart Association Scientific Sessions 2008
  • Place of Presentation: Earnest N.Morial Convention Center, New Orleans, Louisiana, USA
  • Year and Date: 2008-11-09