| Project/Area Number |
20590849
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
|
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| Research Institution | Kawasaki Medical School |
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Principal Investigator |
OKURA Hiroyuki Kawasaki Medical School, 医学部, 准教授 (30425136)
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| Co-Investigator(Kenkyū-buntansha) |
KAWAMOTO Takahiro 川崎医科大学, 医学部, 講師 (30368667)
NEISHI Yoji 川崎医科大学, 医学部, 講師 (80319946)
YOSHIDA Kiyoshi 川崎医科大学, 医学部, 教授 (60322583)
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| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2008: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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| Keywords | 冠動脈 / 不安定プラーク / 血管内超音波 / 光干渉断層法 / 虚血性心疾患 / 動脈硬化 / 血管内光干渉断層法 / 急性冠症候群 / 糖尿病 |
|---|
| Research Abstract |
To investigate plaque characteristics and serial changes in coronary arterial plaque of unstable or vulnerable plaque, intravascular ultrasound (IVUS) and optical coherence tomography (OCT) imaging were performed in patient with coronary artery disease. IVUS-derived tissue characterization revealed that predominant plaque component of the thin-cap fibroatheroma was lipid pool. In addition, positive arterial remodeling contributed to progressive thinning of the fibrous cap.
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