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Development of intracoronary imaging system to predict and stabilize unstable coronary plaque

Research Project

Project/Area Number 20590849
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionKawasaki Medical School

Principal Investigator

OKURA Hiroyuki  Kawasaki Medical School, 医学部, 准教授 (30425136)

Co-Investigator(Kenkyū-buntansha) KAWAMOTO Takahiro  川崎医科大学, 医学部, 講師 (30368667)
NEISHI Yoji  川崎医科大学, 医学部, 講師 (80319946)
YOSHIDA Kiyoshi  川崎医科大学, 医学部, 教授 (60322583)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2008: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Keywords冠動脈 / 不安定プラーク / 血管内超音波 / 光干渉断層法 / 虚血性心疾患 / 動脈硬化 / 血管内光干渉断層法 / 急性冠症候群 / 糖尿病
Research Abstract

To investigate plaque characteristics and serial changes in coronary arterial plaque of unstable or vulnerable plaque, intravascular ultrasound (IVUS) and optical coherence tomography (OCT) imaging were performed in patient with coronary artery disease. IVUS-derived tissue characterization revealed that predominant plaque component of the thin-cap fibroatheroma was lipid pool. In addition, positive arterial remodeling contributed to progressive thinning of the fibrous cap.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (15 results)

All 2011 2010 2009 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (10 results) Remarks (1 results)

  • [Journal Article] Plaque Characteristics of Thin Cap Fibroatheroma evaluated by Optical Coherence Tomography and Integrated Backscatter Intravascular Ultrasound.2011

    • Author(s)
      Miyamoto Y, Okura H, Kume T, Kawamoto T, Neishi Y, Hayashida A, Yamada R, Imai K, Saito K, Yoshida K
    • Journal Title

      JACC Cardiovasc Img (in press)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Plaque characteristics of thin cap fibroatheroma evaluated by optical coherence tomography and integrated backscatter intravascular ultrasound2011

    • Author(s)
      Miyamoto Y, Okura H, Kawamoto T, Neishi Y, Yoshida K, et al.
    • Journal Title

      JACC Cardiovascular Imaging

      Volume: (in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between arterial and fibrous cap remodeling : a serial three-vessel intravascular ultrasound and optical coherence tomography study.2010

    • Author(s)
      Yamada R, Okura H, Kume T, Saito K, Miyamoto Y, Imai K, Tsuchiya T, Maehama T, Okahashi N, Obase K, Hayashida A, Neishi Y, Kawamoto T, Yoshida K
    • Journal Title

      Circ Cardiovasc Intervent Vol.3, No.2

      Pages: 484-490

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between arterial and fibrous cap remodeling : a serial three-vessel intravascular ultrasound and optical coherence tomography study2010

    • Author(s)
      Yamada R, Okura H, Kume T, Saito K, Miyamoto Y, Hayashida A, Yoshida K, et al.
    • Journal Title

      Circulation : Cardiovascular Interventions

      Volume: 3(5) Pages: 484-90

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Arterial Remodeling And Coronary Plaque Compositions : An In Vivo Tissue Characterization using Integrated Backscatter-intravascular Ultrasound.2010

    • Author(s)
      Miyamoto Y, Okura H, Yoshida K, et al.
    • Organizer
      Scientific Sessions 2010, American Heart Association
    • Place of Presentation
      シカゴ、米国
    • Year and Date
      2010-11-14
    • Related Report
      2010 Final Research Report
  • [Presentation] Arterial remodeling and coronary plaque compositions : an in vivo tissue characterization using integrated backscatter-intravagsular ultrasound2010

    • Author(s)
      Miyamoto Y, Okura H, Yoshida K, et al.
    • Organizer
      American Heart Association
    • Place of Presentation
      シカゴ、米国
    • Year and Date
      2010-11-14
    • Related Report
      2010 Annual Research Report
  • [Presentation] 脂質低下療法による線維性被膜の経時的変化:スタンダードスタチンとストロングスタチンの比較2010

    • Author(s)
      山田亮太郎、大倉宏之、宮本欣倫、根石陽二、土谷哲生、川元隆弘、林田晃弘、吉田清
    • Organizer
      第58回日本心臓病学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2010-09-19
    • Related Report
      2010 Final Research Report
  • [Presentation] Changes in Fibrous Cap Thickness in Diabetic and Non-diabetic Patients : A Serial Optical Coherence Tomography Study.2010

    • Author(s)
      山田亮太郎、大倉宏之、根石陽二、川元隆弘、吉田清, ほか
    • Organizer
      第74回日本循環器学会総会・学術集会
    • Place of Presentation
      京都
    • Year and Date
      2010-03-05
    • Related Report
      2010 Final Research Report
  • [Presentation] Changes in Fibrous Cap Thickness in Diabetic and Non-diabetic Patients : A Serial Optical Coherence Tomography Study2010

    • Author(s)
      Yamada R, Okura H, Yoshida K, et al.
    • Organizer
      日本循環器学会総会
    • Place of Presentation
      京都国際会議場(京都府)
    • Year and Date
      2010-03-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] 光干渉断層法とintegrated backscatter intravascular ultrasound によるthin cap fibroaheromaの診断.2009

    • Author(s)
      宮本欣倫、大倉宏之、根石陽二、川元隆弘、吉田清, ほか
    • Organizer
      第57回日本心臓病学会学術集会
    • Place of Presentation
      札幌
    • Year and Date
      2009-09-19
    • Related Report
      2010 Final Research Report
  • [Presentation] Plaque Characteristics of Thin Cap Fibroatheroma evaluated by Optical Coherence Tomography and Integrated Back scatter Intravascular Ultrasound2009

    • Author(s)
      Miyamoto Y, Okura H, Yoshida K, et al.
    • Organizer
      American College of Cardiology
    • Place of Presentation
      オーランド、米国
    • Year and Date
      2009-03-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] Plaque Characteristics of Thin Cap Fibroatheroma evaluated by Optical Coherence Tomography and Integrated Backscatter Intravascular Ultrasound.2009

    • Author(s)
      Miyamoto Y, Okura H, Neishi Y, Kawasmoto T, Yoshida K, et al.
    • Organizer
      Scientific Sessions 2009, American College of Cardiology
    • Place of Presentation
      オーランド、米国
    • Year and Date
      2009-03-29
    • Related Report
      2010 Final Research Report
  • [Presentation] Relationship between the change of fibrous cap thickness and plaque morphology : six months follow-up study of optical coherence tomography and intravascular ultrasound.2009

    • Author(s)
      Yamada R, Okura H, Neishi Y, Kawasmoto T, Yoshida K, et al.
    • Organizer
      Scientific Sessions 2009, American College of Cardiology
    • Place of Presentation
      オーランド、米国
    • Year and Date
      2009-03-29
    • Related Report
      2010 Final Research Report
  • [Presentation] Relationship between the change of fibrous cap thickness and plaque morphology : Six months follow-up study of optical coherence tomography.2009

    • Author(s)
      Yamada R, Okura H, Neishi Y, Kawasmoto T, Yoshida K, et al.
    • Organizer
      第73回日本循環器学会総会・学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2009-03-20
    • Related Report
      2010 Final Research Report
  • [Remarks] ホームページ等

    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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