Efferocytosis as a novel therapeutic target of emphysema
| Project/Area Number |
20590900
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Respiratory organ internal medicine
|
|---|
| Research Institution | Nagasaki University |
|---|
Principal Investigator |
MORIMOTO Konosuke Nagasaki University, 熱帯医学研究所, 准教授 (50346970)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Keywords | 閉塞性肺疾患 / 炎症終息 / 閉塞性肺疾 / アポトーシス |
|---|
| Research Abstract |
We proved the important role of receptor for advanced glycation endproducts (RAGE) in apoptotic cell clearance in inflamed lung. RAGE directly recognized phosphatidylserine on apoptotic cells and enhanced efferocytosis.
We also hypothesized MCP-1 plays crucial role in pathogenesis of chronic inflammation in lung and emphysema. We proved that MCP-1 enhances apoptotic cell clearance through Rac ? PI3K pathway in alveolar macrophages (AMs).
|
Report
(4 results)
Research Products
(11 results)
-
[Journal Article] Receptor for advanced glycation end products binds to phosphatidylserine and assists in the clearance of apoptotic cells.2011
Author(s)
He M, Kubo H, Morimoto K, Fujino N, Suzuki T, Takahasi T, Yamada M, Yamaya M, Maekawa T, Yamamoto Y, Yamamoto H.
-
Journal Title
EMBO Rep. 12(4)
Pages: 358-364
Related Report
Peer Reviewed
-
[Journal Article] Receptor for advanced glycation end products binds to phosphatidylse rine and assists in the clearance of apoptotic cells.2011
Author(s)
He M, Kubo H, Morimoto K, Fujino N, Suzuki T, Takahasi T, Yamada M, Yamaya M, Maekawa T, Yamamoto Y, Yamamoto H
-
Journal Title
EMBO Rep.
Volume: 12
Pages: 358-364
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
