| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Research Abstract |
In the present study, we investigated the role of Nrf2 in protection against the development of acute lung injury. Mice lacking Nrf2 were susceptible to acute lung injury induced by several stimuli, such as bleomycin, lipopolysaccaride, and influenza virus. The induction of several self-defense genes was lower in the lungs of Nrf2-deficient mice than in wild-type mice. Activation of nuclear factor-κB and induction of proinflammatory cytokines were significantly higher in Nrf2-deficient mice than in wild-type mice. Results indicate Nrf2 is a pivotal factor in protection against the development of acute lung injury induced by environmental stimuli.
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