To clarify the mechanism of chronic kidney disease progression by uremic toxins and its application for the treatment
| Project/Area Number |
20590974
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|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Kidney internal medicine
|
|---|
| Research Institution | Shimane University |
|---|
Principal Investigator |
YANO Shozo Shimane University, 医学部, 講師 (80403450)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
SUGIMOTO Toshitsugu 島根大学, 医学部, 教授 (00226458)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
|---|
| Keywords | 尿毒素 / 終末糖化産物 / 血管平滑筋細胞 / 血管石灰化 / 血管内皮細胞 / 副甲状腺ホルモン |
|---|
| Research Abstract |
In vascular endothelial cells, one of uremic toxins, phenyl acetic acid stimulates reactive oxygen species (ROS) production and TNFα in a dose-dependent manner, and ROS inhibitor TEMPOL suppressed TNFα secretion. In vascular smooth muscle cells (VSMC), advanced glycation end-products (AGEs) stimulate NADPH oxidase activity followed by ROS generation, which may play important roles in an osteoblastic trans-differentiation from VSMC and vascular calcification.
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Report
(4 results)
Research Products
(48 results)
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[Book] 副甲状腺腫瘍の疫学2011
Author(s)
矢野彰三, 杉本利嗣
Total Pages
731
Publisher
日本臨床29(3):407-410,2011
Related Report
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