| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
This study is the analysis for the relationship between phosphate overload and vascular calcification in chronic kidney disease. We have performed the study using FGF-23 (Fibroblast Growth Factor-23) as a marker of the phosphate sensing system with novel phosphaturic factor. This study is also the trial of novel prophylaxis modality for vascular damage with vascular calcification and aging.
We have established the model of secondary hyperparathyroidism with vascular calcification as a phosphate and bone disorder in chronic kidney disease. In this in vivo model, we have revealed that main place on phosphate and FGF-23 metabolism is bone. We have also established medial vascular calcification in vitro model using vessel organ culture model. Using the in vitro model, the medial vascular calcification is accelerated under the high phosphate condition via apoptosis and sodium phosphate Pit-1 co-transporter system.
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