Research of mechanism of synemin in neurons of midbrain

• Project/Area Number: 20591016
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neurology
• Research Institution: Gunma University
• Principal Investigator: MIZUNO Yuji Gunma University, 医学部, 講師 (20282395)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: synemin / desmuslin / intermediate filament / muscular dystrophy / dystrobrevin

Research Abstract

We reported that synemin transcript and its protein are more highly expressed in the midbrain and pons of C57BL/6 in 2007, using in situ hybridization and immunohistochemical analysis. In this study, we further focused on the anterior horn cells of spinal cord and showed that synemin transcript and its encoded protein also co-localize in the anterior horn cells.

Research Products

• [Journal Article] Peripherin partially localizes in Bunina bodies in amyotrophic lateral sclerosis. (2011)
  • Author(s): Mizuno Y, Fujita Y, Takatama M, Okamoto K
  • Journal Title: J Neurol Sci 302 Pages: 14-18
  • Peer Reviewed
• [Journal Article] Peripherin partially localizes in Bunina bodies in amyotrophic lateral sclerosis. (2011)
  • Author(s): Mizuno Y, et al
  • Journal Title: Journal of Neurological Sciences Volume: 302 Pages: 14-18
  • Peer Reviewed
• [Journal Article] Tacrolimusを投与した重症筋無力症患者36例の検討 (2010)
  • Author(s): 水野裕司、岡本幸市
  • Journal Title: 神経治療学 27 Pages: 69-75
  • Peer Reviewed
• [Journal Article] Expression of synemin in the mouse spinal cord. (2009)
  • Author(s): Mizuno Y, Guyon JR, Okamoto K, Kunkel LM
  • Journal Title: Muscle Nerve 39 Pages: 634-641
  • Peer Reviewed
• [Journal Article] 中間径フィラメントであるsyneminの研究 (2009)
  • Author(s): 水野裕司
  • Journal Title: KITAKANTO MED J 59 Pages: 281-282
  • NAID: 130000135194
• [Journal Article] Cyclosporinを投与した重症筋無力症9例の検討 (2009)
  • Author(s): 水野裕司、岡本幸市
  • Journal Title: 神経治療学 26 Pages: 189-196
  • Peer Reviewed
• [Journal Article] Expression of synemin in the mouse spinal cord (2009)
  • Author(s): Mizuno Y, et al
  • Journal Title: Muscle Nerve 39 Pages: 634-41
  • Peer Reviewed
• [Journal Article] マウス脳組織におけるsyneminの発現に関する検討 (2008)
  • Author(s): 水野裕司
  • Journal Title: 厚生労働省「精神・神経疾患研究委託費」、筋ジストロフィーおよびその関連する疾患の病態生理の解明と治療薬物の開発に関する研究、班長:清水輝夫、平成17～19年度研究報告書 Pages: 80-81
• [Journal Article] Optineurin in neurodegenerative diseases.
  • Author(s): Osawa T, et al
  • Journal Title: Neuropathology Volume: in press
  • Peer Reviewed
• [Presentation] Optineurin in neurodegenerative diseases. (2011)
  • Author(s): Mizuno Y, Osawa T, Fujita Y, Takatama M, Nakazato Y, Okamoto K
  • Organizer: 10th International Conference on Alzheimer's & Parkinson's Diseases
  • Place of Presentation: Barcelona, Spain
• [Presentation] ゾニサミドを投与したパーキンソン病患者5例の検討 (2010)
  • Author(s): 水野裕司、平柳公利、岡本幸市
  • Organizer: 第28回日本神経治療学会
  • Place of Presentation: 横浜
  • Year and Date: 2010-07-15
• [Presentation] α-dystrobrevinに結合するsyneminとTryptophan Hydroxylase-1の発現について (2010)
  • Author(s): 水野裕司、Jeffrey R. Guyon、Louis M.Kunkel、岡本幸市
  • Organizer: 第51回日本神経学会総会
  • Place of Presentation: 東京
  • Year and Date: 2010-05-20
• [Presentation] α-dystrobrevinに結合するsyneminとTryptophan Hydroxylase-1の発現について (2010)
  • Author(s): 水野裕司, 他
  • Organizer: 第51回日本神経学会総会
  • Place of Presentation: 東京国際フォーラム(東京)
  • Year and Date: 2010-05-20
• [Presentation] Screening the synemin gene for disease causative mutations in patients with myopathic and neurological diseases. (2009)
  • Author(s): Mizuno Y, Guyon JR, Okamoto K, Kunkel LM
  • Organizer: 59th Annual Meeting of the American Society of Human Genetics
  • Place of Presentation: Honolulu, Hawaii, USA
  • Year and Date: 2009-10-21
• [Presentation] 当科においてtacrolimusを使用した重症筋無力症患者35例の検討 (2009)
  • Author(s): 水野裕司、岡本幸市
  • Organizer: 第27回日本神経治療学会
  • Place of Presentation: 熊本
  • Year and Date: 2009-06-11
• [Presentation] α-dystrobrevinに結合するsyneminの脊髄における発現について (2009)
  • Author(s): 水野裕司、Jeffrey R. Guyon、Louis M.Kunkel、岡本幸市
  • Organizer: 第50回日本神経学会総会
  • Place of Presentation: 仙台
  • Year and Date: 2009-05-22
• [Presentation] 画像上胸腺腫の再発性胸膜播腫が疑われたが、組織学的に胸膜デスモイドであった重症筋無力症の1例 (2008)
  • Author(s): 水野裕司、田中司玄文、岡本幸市
  • Organizer: 第26回日本神経治療学会
  • Place of Presentation: 横浜
  • Year and Date: 2008-06-27
• [Presentation] シクロスポリンを投与した糖尿病合併重症筋無力症の2症例 (2008)
  • Author(s): 水野裕司、岡本幸市
  • Organizer: 第26回日本神経治療学会
  • Place of Presentation: 横浜
  • Year and Date: 2008-06-27
• [Presentation] 筋萎縮性側索硬化症の中脳黒質におけるTDP-43の発現に関する検討 (2008)
  • Author(s): 水野裕司、藤田行雄、高玉真光、岡本幸市
  • Organizer: 第49回日本神経病理学会
  • Place of Presentation: 東京
  • Year and Date: 2008-05-20
• [Presentation] α-dystrobrevinに結合するsyneminの脳における発現について (2008)
  • Author(s): 水野裕司、Jeffrey R. Guyon、Louis M.Kunkel、岡本幸市
  • Organizer: 第49回日本神経学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2008-05-16