| Project/Area Number |
20591019
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
HANAJIMA Ritsuko The University of Tokyo, 医学部附属病院, 助教 (80396738)
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| Co-Investigator(Kenkyū-buntansha) |
YASUO Terao 東京大学, 医学部附属病院, 助教 (20343139)
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| Co-Investigator(Renkei-kenkyūsha) |
UWAGA Yoshikazu 福島県立医科大, 医学部, 教授 (50168671)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 磁気刺激法 / 腰部神経根 / 最大上刺激 / 磁気刺激コイル / 神経内科 / 神経生理学 / 末梢神経 / 運動神経 |
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| Research Abstract |
Magnetic stimulation over the spinal roots can give us important physiological information about the most proximal peripheral nerve segments. However, we have two problems for this stimulation method. First, we are not able to activate the spinal motor roots supramaximally by lumbar magnetic simulation because of the deep location of lumbo-sacral spinal roots. The other problem is that spinal roots or nerves are not activated in the spinal canal by magnetic stimulaion. In this investigation, we developed a new lumbar magnetic stimulation method to tackle these problems using a large round coil, twice as large as the usual round coil (MATS coil). With this new method, we obtained supramaximal responses to lumbar roots stimulation in most of normal subjects and activated the most proximal cauda equine or the conus medullari in the spinal canal. . We established the normative data for this new technique. We showed clinical utility of this method by detecting the most proximal part conduction block in some patients with demyelinating polyneuropathy.
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