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Abnormal modulation for spinal neural system in central motor disorders and its reconstruction during functional recovery

Research Project

Project/Area Number 20591021
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurology
Research InstitutionShinshu University

Principal Investigator

MORITA Hiroshi  信州大学, 医学部・附属病院, 准教授 (10262718)

Research Collaborator SHINDO Masaomi  松本大学, 大学院・健康科学研究科, 教授 (90020924)
KODAIRA Minori  信州大学, 医学系研究科, 大学院生
NISHIKAWA Noriko  愛媛大学, 大学院・医学研究科, 講師 (70403813)
SHIMOJIMA Yoshio  飯田市立病院, 神経内科, 医長
Project Period (FY) 2008 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords臨床神経生理学 / 運動調節 / 脊髄抑制機構 / 経頭蓋磁気刺激 / 運動準備 / パーキンソン病 / 痙縮 / H反射 / 脊髄反射
Research Abstract

To investigate inadequate supraspinal modulation and reorganization during functional recovery of spinal neural systems in spasticity and parkinsonism, we tried to set up special experimental system to investigate neural activity before onset of voluntary contraction. Additionally we investigated the safety of transcranial magnetic stimulation(TMS) in patients deep brain stimulation(DBS) system implanted using model system. We concluded that TMS in patients with DBS implanted was safe when we took care some technical procedures.

Report

(6 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report   Self-evaluation Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (30 results)

All 2011 2010 2009 2008 Other

All Journal Article (13 results) (of which Peer Reviewed: 10 results) Presentation (13 results) Remarks (4 results)

  • [Journal Article] A young man with anti-NMDA encephalitis following Guillain-Barre syndrome2011

    • Author(s)
      Tojo K, Nitta K, Ishii W, Sekijima Y, Morita H, et al
    • Journal Title

      Case Reports in Neurology

      Volume: 3 Issue: 1 Pages: 7-13

    • DOI

      10.1159/000323751

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Electrophysiological features of familial amyloid polyneuropathy in endemic area2011

    • Author(s)
      Kodaira M, Morita H, Shimojima Y, Ikeda S
    • Journal Title

      Amyloid

      Volume: 18 Issue: 1 Pages: 10-18

    • DOI

      10.3109/13506129.2010.548424

    • NAID

      120007107404

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Peripheral nerve involvement in primary systemic AL amyloidosis : a clinical and electrophysiological study2011

    • Author(s)
      Matsuda M, Gono T, Morita H, Katoh N, Kodaira M, Ikeda S
    • Journal Title

      Eur J Neurol

      Volume: 18 Issue: 4 Pages: 604-610

    • DOI

      10.1111/j.1468-1331.2010.03215.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Exome sequencing reveals a homozygous SYT14 mutation in adult-onset, autosomal-recessive spinocerebellar ataxia with psychomotor retardation2011

    • Author(s)
      Doi H, Yoshida K, Yasuda T, Fukuda M, Fukuda Y, Morita H, et al
    • Journal Title

      Am J Hum Genet

      Volume: 89 Issue: 2 Pages: 320-327

    • DOI

      10.1016/j.ajhg.2011.07.012

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Extensive brain pathology in a patient with aceruloplasminemia with a prolonged duration of illness2011

    • Author(s)
      Kaneko K, Hineno A, Yoshida K, Ohara S, Morita H, Ikeda SI
    • Journal Title

      Hum Pathol

      Volume: (Epub) Issue: 3 Pages: 451-456

    • DOI

      10.1016/j.humpath.2011.05.016

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The safety of transcranial magnetic stimulation with deep brain stimulation instruments2010

    • Author(s)
      Shimojima Y, Morita H, Nishikawa N, Kodaira M, Hashimoto T, Ikeda SI
    • Journal Title

      Parkinsonism and Related Disorders

      Volume: 16 Pages: 127-131

    • NAID

      120007110391

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The safety of transcranial magnetic stimulation with deep brain stimulation instruments.2010

    • Author(s)
      Shimojima Y, Morita H, Nishikawa N, Kodaira M, Hashimoto T, Ikeda SI.
    • Journal Title

      Parkinsonism and Related Disorders 16

      Pages: 127-131

    • NAID

      120007110391

    • Related Report
      2010 Self-evaluation Report
  • [Journal Article] The safety of transcranial magnetic stimulation with deep brain stimulation instruments.2010

    • Author(s)
      Shimojima Y, Morita H, Nishikawa N, et al.
    • Journal Title

      Parkinsonism and related Disorders

      Volume: 16 Pages: 127-131

    • NAID

      120007110391

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 四肢の筋トーヌス2010

    • Author(s)
      森田洋
    • Journal Title

      Clinical Neuroscience

      Volume: 28 Pages: 738-741

    • Related Report
      2010 Annual Research Report
  • [Journal Article] The safety of transcranial magnetic stimulation with deep brain stimulation instruments.2010

    • Author(s)
      Shimojima Y, Morita H, Nishikawa N, et al.
    • Journal Title

      Parkinsonism and Related Disorders 16

      Pages: 127-131

    • NAID

      120007110391

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Size variance of motor evoked potential at initiation of voluntary contraction in pals yof conversion disorder2008

    • Author(s)
      Morita H, Shimojima Y, Nishikawa N, Hagiwara N, Amano N, Ikeda S
    • Journal Title

      Psychiatry and Clinical Neurosciences

      Volume: 62 Issue: 3 Pages: 286-292

    • DOI

      10.1111/j.1440-1819.2008.01795.x

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Size variance of motor evoked potential at initiation of voluntary contraction in palsy of conversion disorder.2008

    • Author(s)
      Morita H, Shimojima Y, Nishikawa N, Hagiwara N, Amano N, Ikeda S.
    • Journal Title

      Psychiatry and Clinical Neurosciences 62

      Pages: 286-292

    • Related Report
      2010 Self-evaluation Report
  • [Journal Article] Size variance of motor evoked potential at initiation of voluntary contraction in palsy of conversion disorder.2008

    • Author(s)
      Morita H, Shimojima Y, Nishikawa N, et al.
    • Journal Title

      Psychiatry and Clinical Neurosciences 62

      Pages: 286-292

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Inappropriate modulation of antagonistic inhibition at onset ofvoluntary contraction in Parkinson' s disease2010

    • Author(s)
      Morita H
    • Organizer
      29th International Congress ofClinical Neurophysiology
    • Place of Presentation
      Kobe, Japan
    • Year and Date
      2010-10-29
    • Related Report
      2011 Final Research Report
  • [Presentation] Inappropriate modulation of antagonistic inhibition at onset of voluntary contraction in Parkinson's disease.2010

    • Author(s)
      Morita H.
    • Organizer
      29th International Congress of Clinical Neurophysiology
    • Place of Presentation
      Kobe.Japan
    • Year and Date
      2010-10-29
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] Inappropriate modulation of antagonistic inhibition at onset of voluntary contraction in Parkinson's disease.2010

    • Author(s)
      Morita H
    • Organizer
      29th International Congress of Clinical Neurophysiology
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2010-10-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] Inadequate modulation of cortical excitability with voluntary contraction in Parkinson's disease.2009

    • Author(s)
      Morita H., Kodaira M, Shimojima Y, Ikeda S.
    • Organizer
      13^<th> International Congress of Parkinson's Disease and Movement Disorders
    • Place of Presentation
      Paris, France
    • Year and Date
      2009-07-10
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] パーキンソン病における安静時前角細胞群の入出力特性2009

    • Author(s)
      森田洋、小平農,池田修一
    • Organizer
      第49回日本神経学会総会
    • Year and Date
      2009-05-21
    • Related Report
      2011 Final Research Report
  • [Presentation] パーキンソン病における安静時前角細胞群の入出力特性2009

    • Author(s)
      森田洋、小平農、池田修一
    • Organizer
      第49回日本神経学会総会
    • Place of Presentation
      仙台
    • Year and Date
      2009-05-21
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] パーキンソン病における安静時前角細胞群の入出力特性2009

    • Author(s)
      森田洋、小平農, 池田修一
    • Organizer
      第46回日本神経学会総会
    • Place of Presentation
      仙台市
    • Year and Date
      2009-05-21
    • Related Report
      2009 Annual Research Report
  • [Presentation] Inadequate modulation ofcortical excitability with voluntarycontraction in Parkinson' s disease2009

    • Author(s)
      Morita H, Kodaira M, Shimojima Y, Ikeda S
    • Organizer
      13th International Congress of Parkinson' s Disease and Movement Disorders
    • Place of Presentation
      Paris, France
    • Year and Date
      2009-05-10
    • Related Report
      2011 Final Research Report
  • [Presentation] Inadequate modulation of cortical excitability with voluntary contraction in Parkinson's disease.2009

    • Author(s)
      Morita H, Kodaira M, Simojima Y, Ikeda S.
    • Organizer
      13th International Congress of Parkinson's Disease and Movement Disorders
    • Place of Presentation
      Paris, France
    • Year and Date
      2009-05-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] Stiff person症候群における脊髄抑制機構の障害2008

    • Author(s)
      森田洋
    • Organizer
      臨床神経生理学会総会
    • Place of Presentation
      神戸市
    • Year and Date
      2008-11-14
    • Related Report
      2011 Final Research Report
  • [Presentation] Stiff person症候群における脊髄抑制機構の障害2008

    • Author(s)
      森田洋, 小平農, 加藤修明, 池田修一
    • Organizer
      第38回日本臨床神経生理学会総会
    • Place of Presentation
      神戸市
    • Year and Date
      2008-11-14
    • Related Report
      2008 Annual Research Report
  • [Presentation] パーキンソン病における随意運動に伴う磁気刺激強度とMEPの大きさの関係2008

    • Author(s)
      森田洋、小平農、下島吉雄、池田修一
    • Organizer
      第45回日本神経学会総会
    • Year and Date
      2008-05-16
    • Related Report
      2011 Final Research Report 2010 Self-evaluation Report
  • [Presentation] パーキンソン病における随意運動に伴う磁気刺激強度とMEPの大きさの関係2008

    • Author(s)
      森田洋, 小平農, 下島吉雄, 池田修一
    • Organizer
      第49日本神経学会総会
    • Place of Presentation
      横浜市
    • Year and Date
      2008-05-16
    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://soar-rd.shinshu-u.ac.jp/profile/ja.HUyNHhkh.html

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://soar-rd.shinshu-u.ac.jp/profile/ja.HUyNHhkh.html

    • Related Report
      2011 Annual Research Report
  • [Remarks] ホームページ

    • URL

      http://soar-rd.shinshu-u.ac.jp/profile/ja.HUyNHhkh.html

    • Related Report
      2010 Self-evaluation Report
  • [Remarks]

    • URL

      http://soar-rd.shinshu-u.ac.jp/profile/ja.HUyNHhkh.html

    • Related Report
      2010 Annual Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

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