| Project/Area Number |
20591049
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | The University of Tokyo |
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Principal Investigator |
IIZUKA Yoko The University of Tokyo, 医学部附属病院, 助教 (40420244)
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| Co-Investigator(Kenkyū-buntansha) |
YAHAGI Naoya 筑波大学, 大学院・人間総合科学研究科, 准教授 (60420246)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | エネルギー / 糖質代謝異常 / 高血圧自然発症ラット(SHR) / 原因候補遺伝子 / kynurenine aminotransferase 1(KAT-1) / 高血圧 / インスリン抵抗性 / 交感神経活動亢進 / ノックアウトマウス / 肥満 / 高血圧自然発症ラット / kynurenine aminotransferase 1 / 交感神経亢進 / 欠損マウス / RNAiアデノウイルスベクター / 高血圧自然発症ラットSHR / ynurenine aminotransferase 1 / RNAiアデノウイルス |
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| Research Abstract |
1) Normal delivery, normal growth, and null expression of mRNA and protein in each organization of KAT-1 knockout mouse have been confirmed. KAT-1 knockout mouse demonstrates 2) significant increase of blood pressure under the normal chow, more increase of blood pressure under 12 weeks high salt diet by tail-cuff and telemetry system, 3) the rise of 24-hour urine catecholamine secretion under high salt diet, 4) significant increase of fast blood glucose, the rise of insulin resistance by insulin tolerance test under normal chow, 5) the decrease of the fat pat weight under high fat diet accompanied with increase in activity level.
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