Study on energy storage mechanism of ghrelin using transgenic rats whose ghrelin receptor is suppressed

• Project/Area Number: 20591103
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Endocrinology
• Research Institution: Nippon Medical School
• Principal Investigator: SHIBASAKI TAmotsu Nippon Medical School, 大学院・医学研究科, 教授 (00147399)
• Co-Investigator(Kenkyū-buntansha): MANO Asuka 日本医科大学, 医学部, 講師 (50343588) ; NEMOTO Takahiro 日本医科大学, 医学部, 講師 (40366654) ; OHATA Hisayuki 日本医科大学, 医学部, 助教 (80256924)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: グレリン / グレリン受容体 / 体脂肪 / エネルギー代謝

Research Abstract

Transgenic rats expressing an antisense against ghrelin receptor mRNA show reduced adipose tissue. However, it was not clear whether ghrelin is involved in an increase in body fat during aging. This study showed that the inhibitory action of ghrelin on brown adipose tissue increases with aging and that the dorsal medial hypothalamus is involved in its action in rats.

Research Products

• [Journal Article] Genetic suppression of ghrelin receptors activates brown adipocyte function and decreases fat storage in rats. (2010)
  • Author(s): Mano-Otagiri A, Iwasaki-Sekino A, Nemoto T, Ohata H, Shibasaki T.
  • Journal Title: Regulat Pept 160 Pages: 81-90
  • Peer Reviewed
• [Journal Article] Genetic suppression of ghrelin receptors activates brown adipocyte function and decreases fat storage in rats. (2010)
  • Author(s): Mano-Otagiri A., et al
  • Journal Title: Regul Pept 160 Pages: 81-90
  • Peer Reviewed
• [Journal Article] Ghrelin suppreses noradrenaline release in the brown adipose tissue of rats. (2009)
  • Author(s): Mano-Otagiri A, Ohata H, Iwasaki-Sekino A, Shibasaki T.
  • Journal Title: J Endocrinol 201 Pages: 341-349
  • Peer Reviewed
• [Journal Article] Ghrelin suppresses noradrenaline release in the brown adipose tissue of rats. (2009)
  • Author(s): Mano-Otagiri A., et al
  • Journal Title: J Endocrinol 201 Pages: 341-349
  • Peer Reviewed
• [Presentation] 加齢に伴う体脂肪蓄積機序におけるグレリンの役割について (2010)
  • Author(s): 眞野あすか
  • Organizer: 第37回日本神経内分泌学会学術集会
  • Place of Presentation: 京都市
  • Year and Date: 2010-10-22
• [Presentation] 加齢に伴う体脂肪蓄積機序におけるグレリンの役割について (2010)
  • Author(s): 眞野あすか
  • Organizer: 第37回日本神経内分泌学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 2010-10-22
• [Presentation] グレリンによるエネルギー蓄積作用の加齢に伴う変化についての解析 (2009)
  • Author(s): 眞野あすか
  • Organizer: 第82回日本内分泌学会学術総会
  • Place of Presentation: 前橋市
  • Year and Date: 2009-04-24
• [Presentation] グレリンの褐色脂肪組織におけるノルアドレナリン分泌抑制作用への加齢の影響 (2008)
  • Author(s): 眞野あすか
  • Organizer: 第81回日本内分泌学会学術総会
  • Place of Presentation: 青森市
  • Year and Date: 2008-05-18