Identification of iron transporter for mitochondrial iron accumulation in myelodysplastic syndrome.
Project/Area Number |
20591108
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Hematology
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Research Institution | Asahikawa Medical College |
Principal Investigator |
TORIMOTO Yoshihiro Asahikawa Medical College, 医学部, 准教授 (00281882)
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Co-Investigator(Kenkyū-buntansha) |
SATO Kazuya 旭川医科大学, 医学部, 講師 (50360988)
IKUTA Katsuya 旭川医科大学, 医学部, 講師 (00396376)
|
Project Period (FY) |
2008 – 2010
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Project Status |
Completed (Fiscal Year 2010)
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Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | 貧血 / ミトコンドリア / 鉄 / トランスポーター / ABCB7遺伝子 / 骨髄異形成症候群 / 遺伝子 / 鉄過剰 / 鉄代謝 |
Research Abstract |
In this study, we identified the iron transporter gene for mitochondrial iron accumulation in myelodysplastic syndrome (MDS) using bone marrow cells from refractory anemia with ringed sideroblasts (RARS). The decreased expression of ABCB7 gene, which is located on Xq13 and is involved in mitochondrial iron-transport to the cytosol, was observed in the bone marrow cells in the RARS patient with abnormal X-chromosome. Moreover, the levels of ABCB7 mRNA in RARS patients with normal chromosome were also decreased. These findings suggested that the abnormal ABCB7 gene expression contributes to the pathogenesis of mitochondrial iron accumulation in adult MDS patients.
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Report
(4 results)
Research Products
(23 results)
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[Journal Article] Loss of ABCB7 gene : pathogenesis of mitochondrial iron accumulation in erythroblasts in refractory anemia with ringed sideroblast with isodicentric (X)(q13).2011
Author(s)
Sato K, Torimoto Y, Hosoki T, Ikuta K, Takahashi H, Yamamoto M, Ito S, Okamura N, Ichiki K, Tanaka H, Shindo M, Hirai K, Mizukami Y, Otake T, Fujiya M, Sasaki K, Kohgo Y
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Journal Title
Int J Hematol. 93
Pages: 311-318
NAID
Related Report
Peer Reviewed
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[Journal Article] Detection of soluble HFE associated with soluble transferrin receptor in human serum.2011
Author(s)
Ohnishi K, Torimoto Y, Ikuta K, Tanaka H, Hosoki T, Tanaka S, Hamano A, Sato K, Fujiya M, Sasaki K, Kohgo Y
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Journal Title
Int J Mol Med 27
Pages: 435-439
Related Report
Peer Reviewed
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[Journal Article] Loss of ABCB7 gene : pathogenesis of mitochondrial iron accumulation in erythroblasts in refractory anemia with ringed sideroblast with isodic entric(X)(q13).2011
Author(s)
Sato K, Torimoto Y, Hosoki T, Ikuta K, Takahashi H, Yamamoto M, Ito S, Okamura N, Ichiki K, Tanaka H, Shindo M, Hirai K, Mizukami Y, Otake T, Fujiya M, Sasaki K, Kohgo Y.
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Journal Title
Int J Hematol.
Volume: 93
Pages: 311-318
Related Report
Peer Reviewed
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[Journal Article] Detection of soluble HFE associated with soluble transferrin receptor in human serum.2011
Author(s)
Ohnishi K, Torimoto Y, Ikuta K, Tanaka H, Hosoki T, Tanaka S, Hamano A, Sato K, Fujiya M, Sasaki K, Kohgo Y
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Journal Title
Int J Mol Med
Volume: 27
Pages: 435-439
Related Report
Peer Reviewed
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[Journal Article] Heterogeneous expressions of hepcidin isoforms in hepatoma-derived cells detected using simultaneous LC-MS/MS.2009
Author(s)
Hosoki T, Ikuta K, Shimonaka Y, Sasaki Y, Yasuno H, Sato K, Ohtake T, Sasaki K, Torimoto Y, Sato K, Kohgo Y
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Journal Title
Proteomics Clin Appl. 3
Pages: 1256-1264
Related Report
Peer Reviewed
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[Journal Article] Heterogeneous expressions of hepcidin isoforms in hepatome-derived cells detected using simultaneous LC-MS/MS.2009
Author(s)
Hosoki T, Ikuta K, Shimonaka Y, Sasaki Y, Yasuno H, Sato K, Ohtake T, Sasaki K, Torimoto Y, Saito K, Kohgo Y.
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Journal Title
Proteomics-Clinical Applications 3
Pages: 1256-1264
Related Report
Peer Reviewed
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[Presentation] A novel simultaneous quantification of hepcidin isoforms by liquid chromatography-mass spectrometry.2009
Author(s)
Ikuta K, Shimonaka Y, Hosoki T, Sasaki Y, Yasuno H, Okamura N, Shindo M, Ohtake T, Sasaki K, Torimoto Y, Sato K, Kohgo Y
Organizer
第71回日本血液学会学術集会
Place of Presentation
京都(優秀演題)
Year and Date
2009-10-25
Related Report
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[Presentation] Diferric Transferrin-Sensed Hepcidin Upregulation in Human Hepatoma-Derived Cell Line Is Differentially Controlled in Each Isoform 20, 22, 25, Confirmation by a Novel Simultaneous Quantification by Liquid Chromatography/Tandem Mass Spectrometry.2009
Author(s)
Ikuta K, Hosoki T, Shimonaka, Sasaki Y, Yasuno H, Ohtake T, Sasaki K, Torimoto Y, Saito K, Kohgo Y
Organizer
The American Society of Hematology. 51th Annual Meeting and Exposition.
Place of Presentation
New Orleans LA, USA
Related Report
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[Presentation] Diferric transferrin-sensed hepcidin upregulation in human hepatoma-de rived cell line is differentially controlled in each isoform 20, 22, 25 ; confirmation by a novel simultaneous quantification by liquid chromatography/tandem mass spectrometry.2009
Author(s)
Ikuta K, Hosoki T, Shimonaka, Sasaki Y, Yasuno H, Ohtake T, Sasaki K, Torimoto Y, Saito K, Kohgo Y.
Organizer
The American Society of Hematology. 51th Annua 1 Meeting and Exposition.
Place of Presentation
New Orleans LA, USA.
Related Report
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