Genome and Gene expression profiling of EBV-positive diffuse large cell lymphoma of the elderly

• Project/Area Number: 20591142
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Hematology
• Research Institution: Aichi Cancer Center Research Institute
• Principal Investigator: YAMAMOTO Kazuhito Aichi Cancer Center Research Institute, 遺伝子医療研究部, 研究員 (60250247)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 血液腫瘍学 / 悪性リンパ腫 / Epstein-Barr virus / 加齢 / ゲノム異常 / アレイCGH法 / 免疫異常 / 網羅的発現解析

Research Abstract

We explored gene-expression profiling to compare EBV-positive diffuse large B-cell lymphoma (DLBCL) (synonyms: age-related EBV+LPD) with EBV-negative DLBCL. In age-related EBV+LPD, NOD-like receptor and JAK-STAT signaling pathway was showed to be augmented, suggesting that age-related EBV+LPD was characterized by alternation of immune and inflammatory responses.

Research Products

• [Journal Article] Nodal relapse after Helicobacter pylori eradication in a patient with primary localized gastric mucosa-associated lymphoid tissue lymphoma. (2011)
  • Author(s): Kato H, Kagami Y, Kodaira T, Oka S, Oki Y, Chihara D, Taji H, Yatabe Y, Nakamura T, Nakamura S, Seto M, Yamamoto K, Morishima Y.
  • Journal Title: Am J Gastroenterol. 106(3) Pages: 549-551
• [Journal Article] High maximum standard uptake value (SUVmax) on PET scan is associated with shorter survival in patients with diffuse large B cell lymphoma. (2011)
  • Author(s): Chihara D, Oki Y, Onoda H, Taji H, Yamamoto K, Tamaki T, Morishima Y.
  • Journal Title: Int J Hematol. 93(4) Pages: 502-508
  • NAID: 10029534614
• [Journal Article] T細胞性リンパ系腫瘍に対する新規薬剤の導入による新たな治療展開 (2011)
  • Author(s): 牛島洋子、山本一仁
  • Journal Title: 注目される造血器腫瘍に対する新規薬剤の現状と展望 血液内科 62(1) Pages: 51-57
• [Journal Article] R-CHOP therapy for MALT lymphoma of the rectum. (2010)
  • Author(s): Chihara D., Kagami Y., Oki Y., Kato H., Onoda H., Ine S., Taji H., Yamamoto K., Morishima Y.
  • Journal Title: Eur J Haematol. 84(1) Pages: 84-86
• [Journal Article] BCR-ABL-independent and RAS / MAPK pathway-dependent form of imatinib resistance in Ph-positive acute lymphoblastic leukemia cell line with activation of EphB4. (2010)
  • Author(s): Suzuki M., Abe A., Imagama S., Nomura Y., Tanizaki R., Minami Y., Hayakawa F., Ito Y., Katsumi A., Yamamoto K., Emi N., Kiyoi H., Naoe T.
  • Journal Title: Eur J Haematol 84(3) Pages: 229-238
• [Journal Article] Phase I Study of KW-0761, a Defucosylated Humanized Anti-CCR4 Antibody, in Relapsed Patients with Adult T-Cell Leukemia-Lymphoma and Peripheral T-Cell Lymphoma. (2010)
  • Author(s): Yamamoto K., Utsunomiya A., Tobinai K., Tsukasaki K., Uike N., Uozumi K., Yamaguchi K., Yamada Y., Hanada S., Tamura K., Nakamura S., Inagaki H., Ohshima K., Kiyoi H., Ishida T., Matsushima K., Akinaga S., Ogura M., Tomonaga M., Ueda R.
  • Journal Title: J.Clin.Oncol. 28(9) Pages: 1591-1598
• [Journal Article] Primary gastric diffuse large B-cell Lymphoma (DLBCL) : analyses of prognostic factors and value of pretreatment FDG-PET scan. (2010)
  • Author(s): Chihara D., Oki Y., Ine S., Kato H., Onoda H., Taji H., Kagami Y., Yamamoto K., Morishima Y.
  • Journal Title: Eur J Haematol. 84(6) Pages: 493-498
• [Journal Article] Central nervous system involvement in intravascular large B-cell lymphoma : A retrospective analysis of 109 patients. (2010)
  • Author(s): Shimada K., Murase T., Matsue K., Okamoto M., Ichikawa N., Tsukamoto N., Niitsu N., Miwa H., Asaoku H., Kosugi H., Kikuchi A., Matsumoto M., Saburi Y., Masaki Y., Yamamoto K., Yamaguchi M., Nakamura S., Naoe T., Kinoshita T. for the IVL Study Group in Japan
  • Journal Title: Cancer Sci. 101(6) Pages: 1480-1486
  • NAID: 10026593809
• [Journal Article] Clinical impact and predisposing factors of delayed-onset neutropenia after autologous hematopoietic stem-cell transplantation for B-cell non-Hodgkin lymphoma: association with an incremental risk of infectious events. (2010)
  • Author(s): Kato H., Yamamoto K., Matsuo K., Oki Y., Taji H., Kuwatsuka Y., Seto M., Kagami Y., Morishima Y.
  • Journal Title: Ann Oncol. 21(8) Pages: 1699-1705
• [Journal Article] Trough plasma concentration of imatinib reflects BCR-ABL kinase inhibitory activity and clinical response in chronic-phase chronic myeloid leukemia : a report from the BINGO study. (2010)
  • Author(s): Ishikawa Y, Kiyoi H, Watanabe K, Miyamura K, Nakano Y, Kitamura K, Kohno A, Sugiura I, Yokozawa T, Hanamura A, Yamamoto K, Iida H, Emi N, Suzuki R, Ohnishi K, Naoe T.
  • Journal Title: Cancer Sci. 101(10) Pages: 2186-2192
  • NAID: 10027832450
• [Journal Article] CCR4陽性末梢T細胞リンパ腫に対する抗CCR4抗体の臨床試験 (2010)
  • Author(s): 山本一仁
  • Journal Title: 特集:T/NK細胞腫瘍研究の新展開 血液・腫瘍科 60(5) Pages: 614-621
• [Journal Article] 分子標的治療薬に関連する毒性とその対策 (2010)
  • Author(s): 大熊ひでみ、山本一仁
  • Journal Title: 特集:白血病診療essentials.日常診療に必要な最新の診断と治療 内科 106(2) Pages: 285-290
• [Journal Article] Alemtuzumab.連載講座 (2010)
  • Author(s): 山本一仁
  • Journal Title: 分子標的治療薬 Biotherapy 24(5) Pages: 416-420
• [Journal Article] Primary gastric diffuse large B-cell Lymphoma (DLBCL) : analyses of prognostic factors and value of pretreatment FDG-PET scan (2010)
  • Author(s): Chihara D.
  • Journal Title: European J Haematology Volume: 84 Pages: 493-498
  • Peer Reviewed
• [Journal Article] Central nervous system involvement in intravascular large B-cell lymphoma : A retrospective analysis of 109 patients (2010)
  • Author(s): Shimada K.
  • Journal Title: Cancer Science Volume: 101 Pages: 1480-1486
  • Peer Reviewed
• [Journal Article] Clinical impact and predisposing factors of delayed-onset neutropenia after autologous hematopoietic stem-cell transplantation for B-cell non-Hodgkin lymphoma : association with an incremental risk of infectious events (2010)
  • Author(s): Kato H.
  • Journal Title: Annals of Oncology Volume: 21 Pages: 1699-1705
  • Peer Reviewed
• [Journal Article] BCR-ABL-independent and RAS/MAPK pathway-dependent form of imatinib resistance in Ph-positive acute lymphoblastic leukemia cell line with activation of EphB4 (2010)
  • Author(s): Suzuki, M.
  • Journal Title: European Journal of Haematology 84 Pages: 229-238
  • Peer Reviewed
• [Journal Article] Phase I Study of KW-0761, a Defucosylated Humanized Anti-CCR4 Antibody, in Relapsed Patients with Adult T-Cell Leukemia-Lymphoma and Peripheral T-Cell Lymphoma (2010)
  • Author(s): Yamamoto, K.
  • Journal Title: Journal of Clinical Oncolcogy 28 Pages: 1591-1598
  • Peer Reviewed
• [Journal Article] Primary cutaneous T-cell lymphoma of unspecified type with cytotoxic phenotype : clinicopathological analysis of 27 patients. (2009)
  • Author(s): Hagiwara M., Takata K., Shimoyama Y., Yamamoto K., Takahashi E., Asano N., Iwase Y., Okazaki Y., Tamada Y., Yoshino T., Tomita Y., Nakamura S.
  • Journal Title: Cancer Sci. 100(1) Pages: 33-41
  • NAID: 10025141167
• [Journal Article] Age-related EBV-associated B-cell lymphoproliferative disorders : comparison with EBV-positive classical Hodgkin lymphoma in elderly patients. (2009)
  • Author(s): Asano N., Yamamoto K., Tamaru J., Oyama T., Ishida F., Ohshima K., Yoshino T., Nakamura N., Mori S., Yoshie O., Shimoyama Y., Morishima Y., Kinoshita T., Nakamura S.
  • Journal Title: Blood 113(12) Pages: 2629-2636
• [Journal Article] Analysis of prognostic factors in peripheral T-cell lymphoma : prognostic value of serum albumin and mediastinal lymphadenopathy. (2009)
  • Author(s): Chihara D., Oki Y., Ine S., Yamamoto K., Kato H., Taji H., Kagami Y., Yatabe Y., Nakamura S., Morishima Y.
  • Journal Title: Leuk Lymphoma 50(12) Pages: 1999-2004
• [Journal Article] Favorable consolidative effect of high-dose melphalan and total-body irradiation followed by autologous peripheral blood stem cell transplantation after rituximab-containing induction chemotherapy with in vivo purging in relapsed or refractory follicular lymphoma. (2009)
  • Author(s): Kato H., Taji H., Ogura M., Kagami Y., Oki Y., Tsujimura A., Fuwa N., Kodaira T., Seto M., Yamamoto K., Morishima Y.
  • Journal Title: Clin Lymphoma Myeloma 9(6) Pages: 443-448
• [Journal Article] Age-related EBV-associated B-cell lymphoproliferative disorders : diagnostic approach to a newly recognized clinicopathological entity. (2009)
  • Author(s): Shimoyama Y., Asano N., Kojima M., Morishima S., Yamamoto K, Oyama T., Kinoshita T., Nakamura S.
  • Journal Title: Pathol Int. 59(12) Pages: 835-843
  • NAID: 10027382347
• [Journal Article] T細胞リンパ腫-成熟(末梢性)T細胞リンパ腫を中心に (2009)
  • Author(s): 山本一仁
  • Journal Title: 特集:がんの分子標的治療の現状 Medico 40(6)
• [Journal Article] Age-related EBV-associated B-cell lymphoproliferative disorders : comparison with EBV-positive classical Hodgkin lymphoma in elderly patients (2009)
  • Author(s): Asano, N.
  • Journal Title: Blood 113 Pages: 2629-2636
  • Peer Reviewed
• [Journal Article] Age-related EBV-associated B-cell lymphoproliferative disorders : comparison with EBV-positive classical Hodgkin lymphoma in elderly patients (2009)
  • Author(s): Asano N.
  • Journal Title: Blood 113 Pages: 2629-2636
  • Peer Reviewed
• [Journal Article] Phase II study of a salvage regimen using cyclophosphamide, high-dose cytarabine, dexamethasone, etoposide and rituximab (CHASER) in patients with relapsed or refractory B-cell non-Hodgkin lymphoma. (2008)
  • Author(s): Oki Y., Ogura M., Kato H., Kikuch A., Taji H., Kagami Y., Oshiro A., Tsujimura A., Yamamoto K., Morishima Y.
  • Journal Title: Cancer Science 99(1) Pages: 178-184
• [Journal Article] Nagoya Blood and Marrow Transplantation Group : Hematopoietic stem cell transplantation for acute promyelocytic leukemia in second or third complete remission : a retrospective analysis in the Nagoya Blood and Marrow Transplantation Group. (2008)
  • Author(s): Kohno A., Morishita Y., Iida H., Yanada M., Uchida T., Hamaguchi M., Sawa M., Sugiura I., Yamamoto K., Mizuta S, Sao H., Naoe T., Miyamura K.
  • Journal Title: Int J Hematol. 87(2) Pages: 210-216
• [Journal Article] Prognostic value of serum soluble interleukin-2 receptor level in patients with diffuse large B cell lymphoma, treated with CHOP-or RCHOP-based therapy. (2008)
  • Author(s): Oki Y, Kato H, Matsuo K, Kuwatsuka Y, Taji H, Yamamoto K, Kagami Y, Morishima Y.
  • Journal Title: Leuk Lymphoma 49(7) Pages: 1345-1351
• [Journal Article] A retrospective analysis of intravascular large B-cell lymphoma (IVLBCL) treated with rituximab-containing chemotherapies. (2008)
  • Author(s): Shimada K., Matsue K., Yamamoto K., Murase T., Ichikawa N., Okamoto M., Niitsu N., Kosugi H., Tsukamoto N., Miwa H., Asaoku H., Kikuchi A., Matsumoto M., Saburi Y., Masaki Y., Yamaguchi M., Nakamura S., Naoe T., Kinoshita T.
  • Journal Title: J.Clin.Oncol. 26(19) Pages: 3189-3195
• [Journal Article] Low absolute lymphocyte count is a poor prognostic marker in patients with diffuse large B-cell lymphoma and suggests patients' survival benefit from rituximab. (2008)
  • Author(s): Oki Y., Yamamoto K., Kato H., Kuwatsuka Y., Taji H., Kagami Y., Morishima Y.
  • Journal Title: Eur J Haematol. 81(6) Pages: 448-453
• [Journal Article] Age-related Epstein-Barr virus-associated B-cell lymphoproliferative disorders : A review with a special reference to lymphomas surrounding this newly recognized clinicopathologic disease. (2008)
  • Author(s): Shimoyama Y, Yamamoto K, Asano N, Oyama T, Kinoshita T, Nakamura S
  • Journal Title: Cancer Sci. 99(6) Pages: 1085-1091
• [Journal Article] 加齢関連EBV陽性B細胞性リンパ増殖性疾患 (2008)
  • Author(s): 山本一仁、中村栄男
  • Journal Title: 特集:EBウイルス(EBV)とリンパ網内系疾患 血液・腫瘍科 56(3) Pages: 294-298
• [Journal Article] 《悪性リンパ腫を極める:各病理組織型に基づく治療法》マントル細胞リンパ腫 (2008)
  • Author(s): 山本一仁、鍬塚八千代
  • Journal Title: 特集:悪性リンパ腫診療update in 2008-最新のエビデンスに基づく診断と治療 内科 102(2) Pages: 300-305
• [Journal Article] 消化管follicular lymphomaの治療指針 (2008)
  • Author(s): 中村常哉、田近正洋、河合宏紀、鏡味良豊、山本一仁、加藤春美、横井太紀雄、谷田部恭、中村栄男
  • Journal Title: 胃と腸 43(7) Pages: 1081-1084
• [Journal Article] Age-related Epstein-Barr virus-associated B-cell lymphoproliferative disorders : A review with a special reference to lymphomas surrounding this newly recognized clinicopathologic disease (2008)
  • Author(s): Shimoyama Y.
  • Journal Title: Cancer Science 99 Pages: 1085-1091
  • Peer Reviewed
• [Journal Article] A retrospective analysis of intravascular large B-cell lymphoma (IVLBCL) treated with rituximab-containing chemotherapies (2008)
  • Author(s): Shimada K.
  • Journal Title: Journal of Clinical Oncology 26 Pages: 3189-3195
  • Peer Reviewed
• [Presentation] Clinical trials of a defucosylated anti-CCR4 antibody for ATL and PTCL(Joint Symposium with Japanese Society of Lymphoreticular Tissue Research、英語発表). (2010)
  • Author(s): 山本一仁
  • Organizer: 第72回日本血液学会総会
  • Place of Presentation: 横浜市
  • Year and Date: 2010-09-26
• [Presentation] Clinical trials of a defucosylated anti-CCR4 antibody for ATL and PTCL (2010)
  • Author(s): Kazuhito Yamamoto
  • Organizer: 第72回日本血液学会学術集会
  • Place of Presentation: 神奈川県横浜市パシフィコ横浜
  • Year and Date: 2010-09-26
• [Presentation] Multicenter Phase II Study of KW-0761, a Defucosylated Anti-CCR4 Antibody, In Relapsed Patients with Adult T-Cell Leukemia-Lymphoma (ATL) (Oral Session). (2010)
  • Author(s): Takashi Ishida, Tatsuro Joh, Naokuni Uike, Kazuhito Yamamoto, Atae Utsunomiya , Shinichiro Yoshida, Yoshio Saburi, Toshihiro Miyamoto, Shigeki Takemoto, Hitoshi Suzushima, Kunihiro Tsukasaki, Kisato Nosaka, Hiroshi Fujiwara, Kenji Ishitsuka, Hiroshi Inagaki, Michinori Ogura, Shiro Akinaga, Masao Tomonaga, Kensei Tobinai, Ryuzo Ueda
  • Organizer: The 52nd Annual Meeting of American Society of Hematology
  • Place of Presentation: Orlando, FL, U.S.A.
• [Presentation] Increased Peripheral T Cell Responses to EBV-Infected Cells with Frequent Detection of EBV-DNA In Plasma and Viral mRNA In Peripheral B-Cells In Immunocompetent EBV-Positive Diffuse Large B-Cell Lymphoma Patients (Poster Session). (2010)
  • Author(s): Satoko Morishima, Kazuhito Yamamoto, Hiroshi Kimura, Seiko Iwata, Tomohiro Kinoshita, Hirokazu Nagai, Isamu Sugiura, Keitaro Tsushita, Yoshitoyo Kagami, Koichi Miyamura, Kiyotaka Kuzushima, Shigeo Nakamura, Yasuo Morishima.
  • Organizer: The 52nd Annual Meeting of American Society of Hematology
  • Place of Presentation: Orlando, FL, U.S.A.
• [Presentation] Safety and Risk of Allogeneic Peripheral Blood Stem Cell Donation : The Comprehensive Report of Nation-Wide Consecutively Pre-Registered 3,264 Family Donor Survey In 10years Project by Japan Society for Hematopoietic Cell Transplantation (Poster Session). (2010)
  • Author(s): Yoshihisa Kodera, Kazuhito Yamamoto, Shunichi Kato, Mine Harada, Yoshinobu Kanda, Nobuyuki Hamajima, Shigetaka Asano, Yasuo Ikeda, Masahiro Imamura, Keisei Kawa, Yasuo Morishima, Tatsutoshi Nakahat, Mitsune Tanimoto, Ryuji Tanosaki, Shintaro Shiobara, Sung-Won Kim, Koji Nagafuji, Masayuki Hino, Koichi Miyamura, Ritsuro Suzuki.
  • Organizer: The 52nd Annual Meeting of American Society of Hematology
  • Place of Presentation: Orlando, FL, U.S.A.
• [Presentation] A Retrospective Analysis on Prognostic Factors of Angioimmunoblastic T-Cell Lymphoma : a Multicenter Cooperative Study In Japan (Poster). (2010)
  • Author(s): Takashi Tokunaga, Kazuyuki Shimada, Kazuhito Yamamoto, Dai Chihara, Takuji Ichihashi, Rika Oshima, Mitsune Tanimoto, Toshihiro Iwasaki, Atsushi Isoda, Akira Sakai, Hikaru Kobayashi, Kunio Kitamura, Kosei Matsue, Masafumi Taniwaki, Sadahiro Tamashima, Yoshio Saburi, Taro Masunari, Tomoki Naoe, Shigeo Nakamura, Tomohiro Kinoshita.
  • Organizer: The 52nd Annual Meeting of American Society of Hematology
  • Place of Presentation: Orlando, FL, U.S.A.
• [Presentation] Incidence and Risk Factors for Central Nervous System (CNS) Relapse In Patients with Diffuse Large B-Cell Lymphoma (DLBCL) : Analysis with Competing Risk Regression (CRR) Model (Poster Session). (2010)
  • Author(s): Dai Chihara, Yasuhiro Oki, Keitaro Matsuo, Hiroshi Onoda, Hirofumi Taji, Kazuhito Yamamoto, Yasuo Morishima
  • Organizer: The 52nd Annual Meeting of American Society of Hematology.
  • Place of Presentation: Orlando, FL, U.S.A.
• [Presentation] ダサチニブの慢性期慢性骨髄性白血病に対する1 日用量100mg 投与の臨床第II相試験の長期投与成績(口頭) (2009)
  • Author(s): 山本一仁、岡田昌也、坂巻壽、小林幸夫、安藤潔、中川靖章、大西一功、谷脇雅史、宇都宮與、上田享司、大野竜三
  • Organizer: 第71回日本血液学会総会
  • Place of Presentation: 京都市
  • Year and Date: 2009-10-24
• [Presentation] Gastric Diffuse Large B-Cell Lymphoma : Analyses of Prognostic Factors and Value of Pretreatment FDG-PET Scan (Poster Session). (2009)
  • Author(s): Dai Chihara, Yasuhiro Oki, Shouji Ine, Hiroshi Onoda, Harumi Kato, Hirofumi Taji, Yoshitoyo Kagami, Kazuhito Yamamoto, Yasuo Morishima
  • Organizer: 51st Annual Meeting of the American Society of Hematology
  • Place of Presentation: New Orleans, LA, U.S.A.,
• [Presentation] 血管内大細胞型B細胞リンパ腫に対するrituximab 併用化学療法の有用性の検討(プレナリーセッション). (2008)
  • Author(s): 島田和之、末長孝夫、山本一仁、村瀬卓平、市川直明、岡本昌隆、新津望。小杉浩史、塚本憲史、三輪啓志、麻奥英綱、菊池我子、松本守夫、田村和夫、佐分利能生、正木康史、柏村眞、吉田喬、山口素子、中村栄男、直江知樹、木下朝博
  • Organizer: 第70回日本血液学会総会
  • Place of Presentation: 京都市
  • Year and Date: 2008-10-12
• [Presentation] 愛知県がんセンター中央病院におけるimatinib抵抗性・不耐容慢性骨髄性白血病に対するdasatinibの治験成績(ポスター). (2008)
  • Author(s): 山本一仁、大木康弘、田地浩史、加藤春美、鏡味良豊、森島泰雄
  • Organizer: 第70回日本血液学会総会
  • Place of Presentation: 京都市
  • Year and Date: 2008-10-10
• [Presentation] Phase I Study of KW-0761, a Defucosylated Anti-CCR4 Antibody, in Relapsed Patients (Pts) with Adult T-Cell Leukemia-Lymphoma (ATL) or Peripheral T-Cell Lymphoma (PTCL) : Updated Results (Poster Session). (2008)
  • Author(s): Yamamoto K., Tobinai K., Utsunomiya A., Tsukasaki K., Uike N., Uozumi K., Tomonaga M., Matsushima K., Shitara K., Akinaga S., Ueda R.
  • Organizer: 50th Annual Meeting of the American Society of Hematology
  • Place of Presentation: San Francisco, CA, U.S.A.
• [Book] 血液疾患エキスパート「悪性リンパ腫」(加齢性EBウイルス陽性B細胞リンパ腫.) (2010)
  • Author(s): 山本一仁
  • Publisher: 中外医学社
• [Book] 血液診療エキスパート悪性リンパ腫「加齢性EBウイルス陽性B細胞リンパ腫」 (2010)
  • Author(s): 山本一仁
  • Publisher: 中外医学社
• [Book] 慢性リンパ性白血病の適切な初期治療とそのタイミングは?臨床に直結する血液疾患診療のエビデンス (2009)
  • Author(s): 山本一仁、大木康弘
  • Publisher: 文光堂
• [Book] がん化学療法・分子標的治療update(その他のモノクローナル抗体) (2009)
  • Author(s): 山本一仁、森島泰雄
  • Publisher: 中外医学社
• [Book] 悪性リンパ腫治療マニュアル(改訂第3版)(悪性リンパ腫に対する自家末梢血幹細胞移植併用大量化学療法の原理と実際.) (2009)
  • Author(s): 山本一仁
  • Publisher: 南江堂