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Regulation of hematopoiesis by dendritic cells

Research Project

Project/Area Number 20591144
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Hematology
Research InstitutionAkita University

Principal Investigator

SAWADA Kenichi  Akita University, 大学院・医学系研究科, 教授 (90226069)

Co-Investigator(Renkei-kenkyūsha) OHTEKI Toshiaki  東京医科歯科大学, 難治疾患研究所先端分子医学研究部門, 教授 (50233200)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords樹状細胞 / 造血幹細胞 / 自然免疫 / トール様受容体 / 血球貪食症候群 / トール様受容体(TLR)9 / CpG-ODN 2006 / 赤芽球系前駆細胞 / ヒトパルボイルスB19 / TLR3 / poly I:C / TNF阻害剤 / CpG-ODN2006 / ヒトパルボウイルスB19 / エリスロポエチン受容体 / CD34陽性細胞 / 腫瘍壊死因子 / Toll様受容体 / TLR9
Research Abstract

Dendritic cells (DCs) maintain the homeostasis of immunologic system by regulating lymphocyte functions through the production of various cytokines. The collapse of this regulatory system promotes immunologic disorders such as compromised infection, overresponse to immunologic stimuli and autoimmune diseases. DCs might influence differentiation and proliferation of hematopoietic stem cells, however, a large part has remained unclear. This study, at least in part, revealed the mechanism and the physiological role of DCs phagocytosing self-hematopoietic cells and the influence of microbe-derived nucleic acid such as DNA and RNA.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (54 results)

All 2010 2009 2008

All Journal Article (32 results) (of which Peer Reviewed: 32 results) Presentation (21 results) Book (1 results)

  • [Journal Article] CpG-ODN 2006 and human parvovirus B19 genome consensus sequences selectively inhibit growth and development of erythroid progenitor cells.2010

    • Author(s)
      Guo YM, Ishii K, Hirokawa M, Tagawa H, Ohyagi H, Michishita Y, Ubukawa K, Yamashita J, Ohteki T, Onai N, Kawakami K, Xiao W, Sawada K
    • Journal Title

      Blood. 115

      Pages: 4569-4579

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Delayed addition of tumor necrosis factor (TNF) antagonists inhibits the generation of CD11c+ dendritic cells derived from CD34+ cells exposed to TNF-alpha.2010

    • Author(s)
      Guo YM, Hirokawa M, Takahashi N, Fujishima M, Fujishima N, Komatsuda A, Tagawa H, Ohyagi H, Michishita Y, Ubukawa K, Hebiguchi M, Xiao W, Sawada K
    • Journal Title

      Int J Hematol. 91

      Pages: 61-68

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] CpG-ODN 2006 and human parvovirus B19 genome consensus sequences selectively inhibit growth and development of erythroid progenitor cells2010

    • Author(s)
      Guo YM, Ishii K, Hirokawa M, Tagawa H, Ohyagi H, Michishita Y, Ubukawa K, Yamashita J, Ohteki T, Onai N, Kawakami K, Xiao W, Sawada K.
    • Journal Title

      Blood

      Pages: 4569-4579

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CpG-ODN 2006 and human parvovirus B19 genome consensus sequences selectively inhibit growth and development of erythroid progenitor cells2010

    • Author(s)
      Guo YM, Ishii K, Hirokawa M, Tagawa H, Ohyagi H, Michishita Y, Ubukawa K, Yamashita J, Ohteki T, Onai N, Kawakami K, Xiao W, Sawada K.
    • Journal Title

      Blood Epub

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aberrant overexpression of microRNAs activate AKT signaling via down-regulation of tumor suppressors in natural killer-cell lymphoma/leukemia.2009

    • Author(s)
      Yamanaka Y, Tagawa H, Takahashi N, Watanabe A, Guo YM, Iwamoto K, Yamashita J, Saitoh H, Kameoka Y, Shimizu N, Ichinohasama R, Sawada K
    • Journal Title

      Blood. 114

      Pages: 3265-3275

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] MicroRNA-17-92 down-regulates expression of distinct targets in different B-cell lymphoma subtypes.2009

    • Author(s)
      Inomata M, Tagawa H, Guo YM, Kameoka Y, Takahashi N, Sawada K
    • Journal Title

      Blood. 113

      Pages: 396-402

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Delayed addition of tumor necrosis factor (TNF) antagonists inhibits the generation of CD11c+ dendritic cells derived from CD34+ cells exposed to TNF-alpha2009

    • Author(s)
      Guo YM, Hirokawa M, Takahashi N, Fujishima M, Fujishima N, Komatsuda A, Tagawa H, Ohyagi H, Michishita Y, Ubukawa K, Hebiguchi M, Xiao W, Sawada K.
    • Journal Title

      Int J Hematol 91

      Pages: 61-68

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aberrant overexpression of microRNAs activate AKT signaling via down-regulation of tumor suppressors in natural killer-cell lymphoma/leukemia2009

    • Author(s)
      Yamanaka Y, Tagawa H, Takahashi N, Watanabe A, Guo YM, Iwamoto K, Yamashita J, Saitoh H, Kameoka Y, Shimizu N, Ichinohasama R, Sawada K.
    • Journal Title

      Blood 114

      Pages: 3265-3275

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diagnosis and management of acquired pure red cellanlasia2009

    • Author(s)
      Sawada K, Hirokawa M, Fuji shima N.
    • Journal Title

      Hematol Oncol Clin North Am 23

      Pages: 249-259

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Kidney-limited intravascular large B cell lymphoma : a distinct variant of IVLBCL2009

    • Author(s)
      Kameoka Y, Takahashi N, K omatsuda A, Tagawa H, Ham ai K, Hirokawa M, Wakui H, Ichinohasama R, Sawada K I.
    • Journal Title

      Int J Hematol (In press)

    • NAID

      10025161506

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinicopathological features and prognosis in immunoglobulin light and heavy chain deposition disease2009

    • Author(s)
      Masai R, Wakui H, Togashi M, Maki N, Ohtani H, Koma tsuda A, Sawad
    • Journal Title

      Clin Nephrol 71

      Pages: 9-20

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Acquired pure red cell aplasia associated with malignant lymphomas : a nationwide cohort study in Japan for the PRCA Collaborative Study Group2009

    • Author(s)
      Hirokawa M, Sawada K, Fuji shima N, Kawano F, Kimura A, Watanabe T, Arai A, M atsui T, Nakao S, Urabe A, Omine M. Ozawa K.
    • Journal Title

      Am J Hematol 84

      Pages: 144-148

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Marked difference in membrane-protein-binding properties of the two isoforms of protein 4.1R expressed at early and late stages of erythroid differentiation2009

    • Author(s)
      Nunomura W, Parra M, Hebiguchi M, Sawada K, Mohandas N, Takakuwa Y.
    • Journal Title

      Biochem J 417

      Pages: 141-148

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dynamics of human erythroblast enucleation2009

    • Author(s)
      Hebiguchi M, Hirokawa M, Guo YM, Saito K, Wakui H, Komatsuda A, Fujishima N, Takahashi N, Takahashi T, Sasaki T, Nunomura W, Tak akuwa Y, Sawada K.
    • Journal Title

      Int J Hematol 88

      Pages: 498-507

    • NAID

      10023971140

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phagocytosis of co-developing neutrophil progenitors by dendritic cells in a culture of human CD34(+) cells with granulocyte colony-stimulating factor and tumor necrosis factor-alpha.2008

    • Author(s)
      Saito Y, Guo YM, Hirokawa M, Saito K, Komatsuda A, Takahashi N, Fujishima M, Fujishima N, Yamashita J, Sawada K
    • Journal Title

      Int J Hematol. 88

      Pages: 64-72

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cisplatin differently affects amino terminal and carboxyl terminal domains of HSP902008

    • Author(s)
      Ishida R, Takaoka Y, Yamamoto S, Miyazaki T, Otaka M, Watanabe S, Komatsuda A, Wakui H, Sawada K, Kubota H, Itoh H.
    • Journal Title

      FEBS Lett 582

      Pages: 3879-3883

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MicroRNA-17-92 down-regulates expression of distinct targets indifferent B-cell lymphoma subtypes2008

    • Author(s)
      Inomata M, Tagawa H, Guo YM, Kameoka Y, Takahashi N, Sawada K.
    • Journal Title

      Blood 113

      Pages: 396-402

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Successful treatment of post-MRSA infection glomerulonephritis with steroid therapy2008

    • Author(s)
      Okuyama. S, Wakui H, Maki N, Kuroki J, Nishinari T, Asakura K, Komatsuda A, Sawada K.
    • Journal Title

      Clin Nephrol 70

      Pages: 344-347

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Renal amyloidosis associated with extracapillary glomerulonephritis and vasculitis in a patient with inflammatory bowel disease treated with infliximab2008

    • Author(s)
      Hatakeyama T, Komatsuda A, Matsuda A, Togashi M, Maki N, Masai R, Sawada K, Wakui H.
    • Journal Title

      Clin Nephrol 70

      Pages: 240-244

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cutaneous polyarteritis nodosa in a patient with Crohn's disease2008

    • Author(s)
      Komatsuda A, Kinoshita K, Togashi M, Maki N, Masai R, Niitsu H, Ohtani S, Sageshima M, Sawada K, Wakui H.
    • Journal Title

      Mod Rheumatol 18

      Pages: 639-642

    • NAID

      10025111802

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Long-term responses and outcomes following immunosuppressive therapy in large granular lymphocyte leukemia-associated pure red cell aplasia : a Nationwide Cohort Study in Japan for the PRCA Collaborative Study Group2008

    • Author(s)
      Fujishima N, Sawada K, Hir okawa M, Oshimi K, Sugimoto K, Matsuda A, Teramura M, Karasawa M, Arai A, Yonemura Y, Nakao S, Urabe A, Omine M, Ozawa K.
    • Journal Title

      Haematologica 93

      Pages: 1555-1559

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Monoclonal immunoglobulin deposition disease associated with Imembranous features2008

    • Author(s)
      Komatsuda A, Masai R, Ohtani H, Togashi M, Maki N, Sawada K, Wakui H.
    • Journal Title

      Nephrol Dial Transplant 38

      Pages: 3888-3894

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Predominant tubulointerstitial nephritis in a patient with systemic lupus erythematosus : phenotype of infiltrating cells2008

    • Author(s)
      Omokawa A, Wakui H, Okuyama S, Togashi M, Ohtani H, Komatsuda A, Ichinohasama R, Sawada K.
    • Journal Title

      Clin Nephrol. 2008 69

      Pages: 436-444

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Acquired pure red cell aplasia : updated review of treatment2008

    • Author(s)
      Sawada K, Fujishima N, Hirokawa M.
    • Journal Title

      Br J Haematol 142

      Pages: 505-514

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phagocytosis of co-developing neutrophil progenitors by dendritic cells in a culture of human CD34(+) cells with granulocyte colony-stimulating factor and tumor necrosis factor-alpha2008

    • Author(s)
      Saito Y, Guo YM, Hirokawa M, Saito K, Komatsuda A, Takahashi N, Fujishima M, Fujishima N, Yamashita J, Sawada K.
    • Journal Title

      Int J Hematol 88

      Pages: 64-72

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bcr-Abl induces autocrine IGF-1 signaling2008

    • Author(s)
      Lakshmikuttyamma A, Pastural E, Takahashi N, Sawada K, Sheridan DP, DeCoteau JF, Geyer CR
    • Journal Title

      Oncogene 27

      Pages: 3831-3844

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Itraconazole oral solution enhanced vincristine neurotoxicity in five patients with malignant lymphoma. 2008 ; 47(7) : 651-32008

    • Author(s)
      Takahashi N, Kameoka Y, Yamanaka Y, Ubukawa K, Saito K, Fujishima M, Fujishima N, Saito H, Hirokawa M, Scott SA, Sawada K.
    • Journal Title

      Intern Med 47

      Pages: 651-653

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Up-regulated expression of Toll-like receptors mRNAs in peripheral blood mononuclear cells from patients with systemic lupus erythematosus2008

    • Author(s)
      Komatsuda A, Wakui H, Iwamoto K, Ozawa M, Togashi M, Masai R, Maki N, Hatakeyama T, Sawada K.
    • Journal Title

      Clin Exp Immunol 152

      Pages: 482-487

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reversible infliximab-related lymphoproliferative disorder associated with Epstein-Barr virus in a patient with rheumatoid arthritis2008

    • Author(s)
      Komatsuda A, Wakui H, Nimura T, Sawada K.
    • Journal Title

      Mod Rheumatol 18

      Pages: 315-318

    • NAID

      10024151093

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hypertrophic cranial pachymeningitis in a patient with Cogan's syndrome2008

    • Author(s)
      Togashi M, Komatsuda A, Masai R, Maki N, Hatakeyama T, Wakui H, Sawada K.
    • Journal Title

      Clin Rheumatol 27 Suppl 1

      Pages: 33-35

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical features of adult acute leukemia with 11q23 abnormalities in Japan : a co-operative multicenter study2008

    • Author(s)
      Tamai H, Yamaguchi H, Hamaguchi H, Yagasaki F, Bessho M, Kobayashi T, Akiyama H, Sakamaki H, Takahashi S, Tojo A, Ohmine K, Ozawa K, Okumura H, Nakao S, Arai A, Miura O, Toyota S, Gomi S, Murai Y, Usui N, Miyazawa K, Ohyashiki K, Takahashi N, Sawada K, Kato A, Oshimi K, Inokuchi K, Dan K.
    • Journal Title

      Int J Hematol 87

      Pages: 195-202

    • NAID

      10021255726

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gene expression profiling of peripheral blood mononuclear cells from patients with minimal change nephrotic syndrome by cDNA microarrays2008

    • Author(s)
      Komatsuda A, Wakui H, Iwamoto K, Harada M, Okumoto Y, Sawada K.
    • Journal Title

      Am J Nephrol 28

      Pages: 539-547

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Establishment of a murine hemophagocytic syndrome model by administration of CpG and Nod1 ligand.2010

    • Author(s)
      Ohyagi H, Onai N, Guo YM, Takahashi N, Hirokawa M, Sawada K, Ohteki T
    • Organizer
      39^<th> The International Society of Experimental Hematology
    • Place of Presentation
      Melbourne, Victoria, Australia
    • Year and Date
      2010-09-16
    • Related Report
      2010 Final Research Report
  • [Presentation] CPG-ODN 2006 AND HUMAN PARVOVIRUS B19 GENOME CONSENSUS SEQUENCES SELECTIVELY INHIBIT GROWTH AND DEVELOPMENT OF ERYTHROID PROGENITOR CELLS.2010

    • Author(s)
      YM Guo, K Ishii, M Hirokawa, H Tagawa, H Ohyagi, Y Michishita, K Ubukawa, J Yamashita, T Ohteki, N Onai, K Kawakami, W Xiao, K Sawada
    • Organizer
      15^<th> Congress of the European Hematology Association Barcelona
    • Place of Presentation
      Spain
    • Year and Date
      2010-06-11
    • Related Report
      2010 Final Research Report
  • [Presentation] Establishment of a murine hemophagocytic syndrome model by administration of CpG and Mod1 ligand.2010

    • Author(s)
      Ohyagi H, Onai N, Guo YM, Takahashi N, Hirokawa M, Sawada K, Ohteki T
    • Organizer
      第72回日本血液学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2010 Final Research Report
  • [Presentation] CpG-ODN 2006 and parvovirus B19 genome consensus sequences selectively inhibit erythroid growth.2010

    • Author(s)
      Guo YM, Ishii K, Hirokawa M, Tagawa H, Ohyagi H, Michishita Y, Ubukawa K, Yamashita J, Ohteki T, Onai N, Kawakami K, Xiao W, Sawada K
    • Organizer
      第72回日本血液学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2010 Final Research Report
  • [Presentation] ABCG2 C.421C>A Is Associated with Higher Trough Imatinib Plasma Levels in Patients with Chronic Myeloid Leukemia.2009

    • Author(s)
      Takahashi N, Miura M, Scott SA, Sawada K
    • Organizer
      51th Annual Scientific Meeting of The American Society of Hematology
    • Place of Presentation
      New Orleans, Louisiana, USA
    • Year and Date
      2009-12-06
    • Related Report
      2010 Final Research Report
  • [Presentation] Prevention of Hemophagocytosis by TNF- and IL-6 Blockade in TLR9- and Nodl- Ligand Induced Hemophagocytic Syndrome2009

    • Author(s)
      Ohyagi H, Onai N, Guo Y-M, Takahashi N, Hirokawa M, Sawada K, Ohteki T.
    • Organizer
      The 51th Annual Meeting of The American Society of Hematology
    • Place of Presentation
      米国、New Orleans
    • Year and Date
      2009-12-06
    • Related Report
      2009 Annual Research Report
  • [Presentation] Aberrant Overexpressions of MicroRNA-21 and MicroRNA-155 Activate AKT Signaling Via Downregulation of Tumor Suppressors in NK-Cell Lymphoma/Leukemia.2009

    • Author(s)
      Tagawa H, Yamanaka Y, Watanabe A, Takahashi N, Sawada K
    • Organizer
      51th Annual Scientific Meeting of The American Society of Hematology
    • Place of Presentation
      New Orleans, Louisiana, USA
    • Year and Date
      2009-12-05
    • Related Report
      2010 Final Research Report
  • [Presentation] Prevention of Hemophagocytosis by TNF-α and IL-6 Blockade in TLR9- and Nod1- Ligand Induced Hemophagocytic Syndrome.2009

    • Author(s)
      Ohyagi H, Onai N, Guo Y-M, Takahashi N, Hirokawa M, Sawada K, Ohteki T
    • Organizer
      Saturday, December 5, 2009, 51th Annual Scientific Meeting of The American Society of Hematology
    • Place of Presentation
      New Orleans, Louisiana, USA
    • Related Report
      2010 Final Research Report
  • [Presentation] Aberrant over expressions of microRNAs activate AKT signaling in NK/T cell lymphoma/leukemia.2009

    • Author(s)
      Tagawa H., Ymanaka Y., Takahashi N., Y, M, Guo., Ichinohasama R., Shimizu N., Sawada K.
    • Organizer
      71回日本血液学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2010 Final Research Report
  • [Presentation] 赤芽球癆の全国アンケート調査集計結果とその解析続発性赤芽球癆 : 顆粒リンパ球増多症2008

    • Author(s)
      藤島直仁, 澤田賢一, 廣川誠, 押味和夫, 杉本耕一, 松田晃, 寺村正尚, 唐沢正光, 新井文子, 米村雄士, 中尾眞二, 浦部晶夫, 小峰光博, 小澤敬也
    • Organizer
      第70回日本血液学会総会
    • Place of Presentation
      京都
    • Related Report
      2008 Annual Research Report
  • [Presentation] 悪性リンパ腫に合併した赤芽球癆の臨床病理学的特徴 : 特発性造血障害調査研究班による全国調査報告2008

    • Author(s)
      廣川誠, 澤田賢一, 藤島直仁, 河野文夫, 木村昭郎, 渡辺隆, 新井文子, 松井利充, 中尾眞二, 浦部晶夫, 小峰光博, 小澤敬也
    • Organizer
      第70回日本血液学会総会
    • Place of Presentation
      京都
    • Related Report
      2008 Annual Research Report
  • [Presentation] 発作性夜間ヘモグロビン尿症(PNH)サブカテゴリー新分類の本邦PNH症例に対する適用2008

    • Author(s)
      野地秀義, 池田和彦, 高橋直人, 亀岡淳一, 田嶋克史, 村井一範, 玉井佳子, 七島晶子, 阿久津和子, 岡本正俊, 木村秀夫, 竹石恭知, 佐々木毅, 澤田賢一, 七島勉
    • Organizer
      第70回日本血液学会総会
    • Place of Presentation
      京都
    • Related Report
      2008 Annual Research Report
  • [Presentation] 再生不良性貧血に対する免疫抑制療法後のシクロスポリン依存性の検討2008

    • Author(s)
      亀岡淳一, 高橋直人, 菅原知広, 目黒邦昭, 奥田光崇, 野地秀義, 七島勉, 加藤裕一, 田嶋克史, 赤木智昭, 村井一範, 石田陽治, 張替秀郎, 澤田賢一
    • Organizer
      第70回日本血液学会総会
    • Place of Presentation
      京都
    • Related Report
      2008 Annual Research Report
  • [Presentation] 後天性骨髄不全症候群症例における血清ハプトグロビン値の意義2008

    • Author(s)
      高橋裕志, 池田和彦, 高橋直人, 亀岡淳一, 田嶋克史, 村井一範, 玉井佳子, 七島晶子, 阿久津和子, 野地秀義, 岡本正俊, 木村秀夫, 小山田隆、亀先豊美, 梶井英治, 竹石恭知, 佐々木毅, 澤田賢一, 七島勉
    • Organizer
      第70回日本血液学会総会
    • Place of Presentation
      京都
    • Related Report
      2008 Annual Research Report
  • [Presentation] ヒト赤芽球の脱核は細胞分裂に類似するがcentrosome非依存性である2008

    • Author(s)
      郭永梅, 蛇口美和, 廣川誠, 大八木秀明, 齊藤邦江, 小松田敦, 高橋直人, 藤島直仁, 藤島眞澄, 澤田賢一
    • Organizer
      第70回日本血液学会総会
    • Place of Presentation
      京都
    • Related Report
      2008 Annual Research Report
  • [Presentation] 当科で経験したprimary CNS lymphomaの10例の臨床病理学的検討2008

    • Author(s)
      亀岡吉弘, 高橋直人, 田川博之, 鵜生川久美, 猪又美佳, 山中康生, 齊藤邦江, 藤島直仁, 藤島眞澄, 吉岡智子, 齊藤宏文, 廣川誠, 一迫玲, 澤田賢一
    • Organizer
      第70回日本血液学会総会
    • Place of Presentation
      京都
    • Related Report
      2008 Annual Research Report
  • [Presentation] 悪性リンパ腫におけるmicroRNA-17-92の標的の探索2008

    • Author(s)
      田川博之, 猪又美佳, 亀岡吉弘, 郭永梅, 山中康生, 吉岡智子, 高橋直人, 澤田賢一
    • Organizer
      第70回日本血液学会総会
    • Place of Presentation
      京都
    • Related Report
      2008 Annual Research Report
  • [Presentation] ヒト赤芽球はマクロファージの関与なく脱核するが核の切り離しに外力を必要とする2008

    • Author(s)
      蛇口美和, 廣川誠, 郭永梅, 齊藤邦江, 涌井秀樹, 小松田敦, 飯塚了太, 佐々木雄彦, 布村渉, 高桑雄一, 澤田賢一
    • Organizer
      第70回日本血液学会総会
    • Place of Presentation
      京都
    • Related Report
      2008 Annual Research Report
  • [Presentation] 完全寛解後、再発時に皮膚生検で確定診断された心臓原発非ホジキンリンパ腫2008

    • Author(s)
      西成民夫, 黒木淳, 澤田賢一
    • Organizer
      第70回日本血液学会総会
    • Place of Presentation
      京都
    • Related Report
      2008 Annual Research Report
  • [Presentation] 慢性骨髄性白血病におけるイマチニブ血中濃度と有効性の相関についての検討2008

    • Author(s)
      高橋直人, 亀岡吉弘, 小笠原仁, 波多野善明, 黒木淳, 高橋薫, 茂木睦仁, 久米正晃, 北林淳, 大嶋厚志, 西成民夫, 渡辺新, 齊藤公基, 中鉢明彦, 仁村隆, 齊藤宏文, 廣川誠, 澤田賢一
    • Organizer
      第70回日本血液学会総会
    • Place of Presentation
      京都
    • Related Report
      2008 Annual Research Report
  • [Presentation] 自家末梢血幹細胞移植が著効したCD56陽性ALK陰性anaplastic large cell lymphoma2008

    • Author(s)
      三田亜紀子, 川端良成, 木川顕博, 北林淳, 廣川誠, 澤田賢一
    • Organizer
      第70回日本血液学会総会
    • Place of Presentation
      京都
    • Related Report
      2008 Annual Research Report
  • [Book] 「ガイドライン外来診療2008」貧血,今日の診療のために2008

    • Author(s)
      澤田賞一
    • Publisher
      編集主幹 泉孝英, 日経メディカル開発
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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