Analysis of regulation of antigen-specific IgE production in BALT
Project/Area Number |
20591184
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
膠原病・アレルギー・感染症内科学
|
Research Institution | Chiba University |
Principal Investigator |
KAGAMI Shin-ichiro Chiba University, 大学院・医学研究院, 助教 (30375654)
|
Co-Investigator(Kenkyū-buntansha) |
中島 裕史 千葉大学, 大学院・医学研究院, 教授 (00322024)
須藤 明 千葉大学, 大学院・医学研究院, 助教 (50447306)
|
Project Period (FY) |
2008 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 肺内胚中心様組織 / IL-21 / TFH細胞様細胞 / BTLA / IgE / IgG4関連疾患 / 喘息 / T_<FH>細胞 / CXCR5 |
Research Abstract |
We found that TFH-like cells existed in inducible bronchus-associated lymphoid tissue (iBALT) and expressed high levels of ICOS, PD-1 and BTLA in a murine model of asthma. In addition, we found that TFH-like cells produced a large amount of IL-21 upon TCR stimulation. We also found that patients with IgG4-related lacrimal gland enlargement (LGE) developed asthma-like symptoms. All patients with IgG4-related LGE showed ectopic germinal center-like architecture in lacrimal glands and exhibited elevated serum IgE levels. CD4^+ T cells in patients with IgG4-related LGE exhibited enhanced Th2 cytokine production as compared with those in healthy subjects.
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Report
(4 results)
Research Products
(30 results)