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Functional analysis of novel effectors correlated with allergic diseases

Research Project

Project/Area Number 20591188
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 膠原病・アレルギー・感染症内科学
Research InstitutionSaga University

Principal Investigator

IZUHARA Kenji  Saga University, 医学部, 教授 (00270463)

Co-Investigator(Kenkyū-buntansha) OHTA Shoichiro  佐賀大学, 医学部, 助教 (20346886)
KANAJI Sachiko  佐賀大学, 医学部, 助教 (50363429)
SHIRAISHI Hiroshi  佐賀大学, 医学部, 助教 (80452837)
ARIMA Kazuhiko  佐賀大学, 医学部, 講師 (60336112)
SUZUKI Shoichi  佐賀大学, 医学部, 助教 (40253695)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsアレルギー・ぜんそく / 遺伝子 / 蛋白質 / 免疫学
Research Abstract

It is known that IL-13, one of Th2-type cytokines, is important for the pathogenesis of bronchial asthma. In this study, we found the signals via Toll-like 4 receptor inhibit IL-13 production, how IL-13 interacts with its receptor, and IL-13 evokes allergic inflammation via pendrin, an anion transporter. We could show the detailed mechanism of how IL-13 causes bronchial asthma by these results.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (99 results)

All 2011 2010 2009 2008 Other

All Journal Article (44 results) (of which Peer Reviewed: 38 results) Presentation (25 results) Book (8 results) Remarks (4 results) Patent(Industrial Property Rights) (18 results)

  • [Journal Article] Periostin, a matrix protein, has potential as a novel serodiagnostic marker for cholangiocarcinoma2011

    • Author(s)
      Fujimoto K, Kawaguchi T, Nakashima O, Ono J, Ohta S, Kawaguchi A, Tonan T, Ohshima K, Yano H, Hayabuchi N, Izuhara K,Sata M
    • Journal Title

      Oncol Rep Vol.25, No.5

      Pages: 1211-1216

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Periostin, a matrix protein, has potential as a novel serodiagnostic marker for cholangiocarcinoma2011

    • Author(s)
      Fujimoto K
    • Journal Title

      Oncol Rep.

      Volume: 25 Pages: 1211-1216

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Endotoxin tolerance attenuates airway allergic inflammation in model mice by suppression of the T-cell stimulatory effect of dendritic cells2010

    • Author(s)
      Matsushita H, Ohta S, Shiraishi H, Suzuki S, Arima K, Toda S, Tanaka H, Nagai H, Kimoto M, Inokuchi A, Izuhara K
    • Journal Title

      Int Immunol Vol.22, No.9

      Pages: 739-747

    • NAID

      10030913704

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between squamous cell carcinoma antigen and the clinical severity of allergic rhinitis caused by Dermatophagoides farinae and japanese cedar pollen2010

    • Author(s)
      Suzuki K, Inokuchi A, Miyazaki J, Kuratomi Y, Izuhara K
    • Journal Title

      Ann Oto Rhinol Laryn Vol.119, No.1

      Pages: 22-26

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] IL-4とIL-13のレセプターとの結合様式2010

    • Author(s)
      出原賢治
    • Journal Title

      臨床免疫・アレルギー科 Vol.54

      Pages: 613-618

    • NAID

      40017405376

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] アレルギー疾患の生化学的検査方法2010

    • Author(s)
      出原賢治
    • Journal Title

      臨床と研究 Vol.87

      Pages: 221-225

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Endotoxin tolerance attenuates airway allergic inflammation in model mice by suppression of the T-cell stimulatory effect of dendritic cells.2010

    • Author(s)
      Matsushita H
    • Journal Title

      Int Immunol

      Volume: 22 Pages: 739-747

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between squamous cell carcinoma antigen and the clinical severity of allergic rhinitis caused by Dermatophagoides farinae and japanese cedar pollen.2010

    • Author(s)
      Suzuki K
    • Journal Title

      Ann Oto Rhinol Laryn.

      Volume: 119 Pages: 22-26

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IL-4とIL-13のレセプターとの結合様式2010

    • Author(s)
      出原賢治
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 54 Pages: 613-618

    • NAID

      40017405376

    • Related Report
      2010 Annual Research Report
  • [Journal Article] アレルギー疾患の生化学的検査方法2010

    • Author(s)
      出原賢治
    • Journal Title

      臨床と研究

      Volume: 87 Pages: 221-225

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Relationship between squamous cell carcinoma antigen and the clinical severity of allergic rhinitis caused by Dermatophagoides farinae and japanese cedar pollen2010

    • Author(s)
      Suzuki K
    • Journal Title

      Ann Oto Rhinol Laryn 119

      Pages: 22-26

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] アレルギー疾患の生化学的検査方法2010

    • Author(s)
      出原賢治
    • Journal Title

      臨床と研究 87

      Pages: 221-225

    • Related Report
      2009 Annual Research Report
  • [Journal Article] The mechanism of mucus production in bronchial asthma2009

    • Author(s)
      Izuhara K, Ohta S, Shiraishi H, Suzuki S, Taniguchi K, Toda S, Tanabe T, Yasuo M, Kubo K, Hoshino T, Aizawa H
    • Journal Title

      Curr Med Chem Vol.16, No.22

      Pages: 2867-2875

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Distinct structural requirements for interleukin-4 (IL-4) and IL-13 binding to the shared IL-13 receptor facilitate cellular tuning of cytokine responsiveness2009

    • Author(s)
      Ito T, Suzuki S, Kanaji S, Shiraishi H, Ohta S, Arima K, Tanaka G,Tamada T Honjo E, Garcia KC,Kuroki R, Izuhara K
    • Journal Title

      J Biol Chem Vol.284, No.36

      Pages: 24289-24296

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of four novel mutations in F5 associated with congenital factor V deficiency2009

    • Author(s)
      Kanaji S, Kanaji T, Honda M, Nakazato S, Wakayama K, Tabata Y, Shibata S, Gondo H, Nakamura I, Node K, Miura M, Miyahara M, Okumura T, Nagumo F, Ohta S, Izuhara K
    • Journal Title

      Int J Haematol Vol.89

      Pages: 71-75

    • NAID

      10025159727

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] IL-4/IL-13で誘導されるアレルギー性炎症2009

    • Author(s)
      出原賢治
    • Journal Title

      実験医学 Vol.27

      Pages: 3297-3302

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] アレルギー疾患発症機序における環境要因の役割2009

    • Author(s)
      出原賢治
    • Journal Title

      臨床環境医学 Vol.18

      Pages: 67-74

    • NAID

      10029423777

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The mechanism of mucus production in bronchial asthma2009

    • Author(s)
      Izuhara K
    • Journal Title

      Curr Med Chem 16

      Pages: 2867-2875

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Distinct structural requirements for interleukin-4(IL-4)and IL-13 binding to the shared IL-13 receptor facilitate cellular tuning of cytokine responsiveness2009

    • Author(s)
      Ito T
    • Journal Title

      J Biol Chem 284

      Pages: 24289-24296

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of four novel mutations in F5 associated with congenital factor V deficiency2009

    • Author(s)
      Kanaji S
    • Journal Title

      Int J Hematol 89

      Pages: 71-75

    • NAID

      10025159727

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IL-4/IL-13で誘導されるアレルギー性炎症.2009

    • Author(s)
      出原賢治
    • Journal Title

      実験医学 27

      Pages: 3297-3302

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 基礎研究と応用研究との橋渡しへ.2009

    • Author(s)
      出原賢治
    • Journal Title

      呼吸 28

      Pages: 339-340

    • Related Report
      2009 Annual Research Report
  • [Journal Article] アレルギー疾患発症機序における環境要因の役割2009

    • Author(s)
      出原賢治
    • Journal Title

      臨床環境医学 18

      Pages: 68-74

    • NAID

      10029423777

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Identification of four novel mutations in F5 associated with congenital factor V deficiency.2009

    • Author(s)
      Kanaji Sachiko
    • Journal Title

      Int. J. Hematol. 89

      Pages: 71-75

    • NAID

      10025159727

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Recent progress in understanding the diversity of the human ov-serpin/clade B serpin family2008

    • Author(s)
      Izuhara K, Ohta S, Kanaji S, Shiraishi H, Arima K
    • Journal Title

      Cell Mol Life Sci Vol.65

      Pages: 2541-2553

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of cysteine protease inhibitors in the defense mechanism against parasites2008

    • Author(s)
      Izuhara K, Kanaji S, Arima K, Ohta S, Shiraishi H
    • Journal Title

      Med Chem Vol.4

      Pages: 322-327

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of pendrin as a common mediator for mucus production in bronchial asthma and chronic obstructive pulmonary disease2008

    • Author(s)
      Nakao I, Kanaji S, Ohta S, Matsushita H, Arima K, Yuyama N, Yamaya M, Nakayama K, Kubo H, Watanabe M, Sagara H, Sugiyama K, Tanaka H, Toda S, Hayashi H, Inoue H, Hoshino T, Shiraki A, Inoue M, Suzuki K, Aizawa H, Okinami S, Nagai H, Hasegawa M, Fukuda T, Green ED, Izuhara K
    • Journal Title

      J Immunol Vol.180, No.9

      Pages: 6262-6269

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression of the extracellular region of the human interleukin-4 receptor α chain and interleukin-13 receptor α 1 chain by a silkworm-baculovirus system2008

    • Author(s)
      Honjo E, Shoyama Y, Tamada T, Shigematsu H, Hatanaka T, Kanaji S, Arima K, Ito Y, Izuhara K, Kuroki R
    • Journal Title

      Protein Expr Purif Vol.60

      Pages: 25-30

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of a patient with atypical amegakaryocytic thrombocytopenia2008

    • Author(s)
      Kanaji S, Kanaji T, Migita M, Kunishima S, Okamura T, TJ Kunicki, Izuhara K
    • Journal Title

      Eur J Haematol Vol.80

      Pages: 361-364

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Periostin and bone marrow fibrosis2008

    • Author(s)
      Oku E, Kanaji T, Tanaka Y, Ohshima K, Seki R, Morishige S, Imamura R, Ohtsubo K, Hashiguchi M, Osaki K, Yakushiji K, Yoshimoto K, Ogata H, Hamada H, Izuhara K, Sata M, Okumura T
    • Journal Title

      Int J Hematol Vol.88

      Pages: 57-63

    • NAID

      10025159122

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] A new organotypic culture of adipose tissue fragments maintains viable mature adipocytes for a long term, together with development of immature adipocytes and mesenchymal stem cell-like cells2008

    • Author(s)
      Sonoda E, Aoki S, Uchihashi K, Soejima H, Kanaji S, Izuhara K, Satoh S, Fujitani N, Sugihara H, Toda S
    • Journal Title

      Endocrinology Vol.149, No.10

      Pages: 4794-4798

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] IL-13を基盤としたアレルギー疾患の病態形成機序と治療戦略2008

    • Author(s)
      出原賢治
    • Journal Title

      喘息と遺伝学 Vol.10

      Pages: 58-66

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 遺伝子検査の現状と展望2008

    • Author(s)
      出原賢治
    • Journal Title

      Medical Technology Vol.36

      Pages: 409-411

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 喘息患者における遺伝子多型2008

    • Author(s)
      出原賢治
    • Journal Title

      呼吸 Vol.27

      Pages: 1044-1048

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Recent progress in understanding the diversity of the human ov-serpin/clade B serpin family.2008

    • Author(s)
      Izuhara Kenji
    • Journal Title

      Cell. Mol. Life Sci. 65

      Pages: 2541-2553

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of cysteine protease inhibitors in the defence mechanism against parasites.2008

    • Author(s)
      Izuhara Kenji
    • Journal Title

      Med. Chem. 4

      Pages: 322-327

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of pendrin as a common mediator for mucus production in bronchial asthma and chronic obstructive pulmonary disease.2008

    • Author(s)
      Nakao Isao
    • Journal Title

      J. Immunol. 180

      Pages: 6262-6269

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of a patient with atypical amegakaryocytic thrombocytopenia.2008

    • Author(s)
      Kanaji Sachiko
    • Journal Title

      Eur. J. Hematol. 80

      Pages: 361-364

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Periostin and bone marrow fibrosis.2008

    • Author(s)
      Oku Eijiro
    • Journal Title

      Int. J. Hematol. 88

      Pages: 57-63

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of the extracellular region of the human interleukin-4 receptor alpha chain and interleukin-13 receptor alphal chain by a silkworm-baculovirus system.2008

    • Author(s)
      Honjo Eijiro
    • Journal Title

      Protein Expr. Purif. 60

      Pages: 25-30

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A new organotyplc culture of adipose tissue fragments maintains viable mature adipocytes for a long term, together with development of immature adipocytes and mesenchymal stem cell-like cells.2008

    • Author(s)
      Sonoda Emiko
    • Journal Title

      Endocrinology 149

      Pages: 4794-4798

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IL-13を基盤としたアレルギー疾患の病態形成機序と治療戦略.2008

    • Author(s)
      出原賢治
    • Journal Title

      喘息と遺伝学(International review of asthma) 10

      Pages: 58-66

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 遺伝子検査の現状と展望.2008

    • Author(s)
      出原賢治
    • Journal Title

      Medical Technology 36

      Pages: 409-411

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 喘息患者における遺伝子多型.2008

    • Author(s)
      出原賢治
    • Journal Title

      呼吸 27

      Pages: 1044-1048

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] マイクロアレイによるIL-13誘導遺伝子とその機能解析2010

    • Author(s)
      出原賢治
    • Organizer
      第60回日本アレルギー学会秋季学術大会
    • Place of Presentation
      東京
    • Year and Date
      2010-11-25
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] Periostin, an extracellular matrix protein, is a critical mediator for amplifocation and chronicity of inflammation in atopic dermatitis2010

    • Author(s)
      Masuoka M
    • Organizer
      14^h International congress of Immunology
    • Place of Presentation
      神戸(日本)
    • Year and Date
      2010-08-23
    • Related Report
      2010 Final Research Report
  • [Presentation] Periostin, an extracellular matrix protein, acts as a master switch for the onset of inflammation in atopic dermatitis2010

    • Author(s)
      出原賢治
    • Organizer
      Symposium of the collegium Internationalale Allergologicum
    • Place of Presentation
      Ischia (Italy)
    • Year and Date
      2010-04-28
    • Related Report
      2010 Final Research Report
  • [Presentation] Periostin, an extracellular matrix protein, acts as a master switch for the onset of inflammation in atopic dermatitis.2010

    • Author(s)
      Izuhara K
    • Organizer
      28th Symposium of the Collegiums Internationalale Allergologicum
    • Place of Presentation
      Ischia (Italy)
    • Year and Date
      2010-04-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] Periostin, a matrix protein, is a novel serodiagnostic marker for cholangiocarcinoma2010

    • Author(s)
      Kawaguchi T
    • Organizer
      The 61^<th> annual meeting of the American association for the study of Liver diseases, The Liver Meeting
    • Place of Presentation
      Boston (USA)
    • Related Report
      2010 Final Research Report
  • [Presentation] A new paradigm in the pathogenesis of atopic dermatitis2009

    • Author(s)
      出原賢治
    • Organizer
      XXI World Allergy Congress 2009
    • Place of Presentation
      Buenos Aires (Argentina)
    • Year and Date
      2009-12-08
    • Related Report
      2010 Final Research Report
  • [Presentation] A new paradigm in the pathogenesis of atopic dermatitis2009

    • Author(s)
      Izuhara K
    • Organizer
      XXI World Allergy Congress
    • Place of Presentation
      (ブエノスアイレス)アルゼンチン
    • Year and Date
      2009-12-08
    • Related Report
      2009 Annual Research Report
  • [Presentation] サイトカインとアレルギー疾患2009

    • Author(s)
      出原賢治
    • Organizer
      第46回日本小児アレルギー学会
    • Place of Presentation
      福岡
    • Year and Date
      2009-12-05
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] アレルギー疾患の生化学的検査方法2009

    • Author(s)
      出原賢治
    • Organizer
      第59回日本アレルギー学会秋季学術大会
    • Place of Presentation
      秋田
    • Year and Date
      2009-10-29
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] オーダーメイド医療を目指したアレルギー疾患における病因診断システムの確立2009

    • Author(s)
      出原賢治
    • Organizer
      第56回日本臨床検査医学会学術集会
    • Place of Presentation
      札幌
    • Year and Date
      2009-08-28
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] アレルギー疾患の発症機序における環境要因の役割2009

    • Author(s)
      出原賢治
    • Organizer
      第18回日本臨床環境医学会学術集会
    • Place of Presentation
      岡山
    • Year and Date
      2009-07-03
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] Periostin plays an important role in the pathogenesis of pulmonary fibrosis2009

    • Author(s)
      Uchida M
    • Organizer
      Keystone symposia on Molecular and Cellular Biology
    • Place of Presentation
      Keystone (USA)
    • Year and Date
      2009-01-23
    • Related Report
      2010 Final Research Report
  • [Presentation] Inhibitory effects of TLR4 signals on allergic airway inflammation2009

    • Author(s)
      Matsushita H
    • Organizer
      Keystone symposia on Molecular and Cellular Biology
    • Place of Presentation
      Keystone (USA)
    • Year and Date
      2009-01-22
    • Related Report
      2010 Final Research Report
  • [Presentation] Enhanced expression of periostin in lungs and sera of idiopathic pulmonary fibrosis2009

    • Author(s)
      Hoshino T
    • Organizer
      14^<th> Congress of the Asian Pacific Society of Respirology
    • Place of Presentation
      Seoul (Korea)
    • Related Report
      2010 Final Research Report
  • [Presentation] Expression of periostin in small peripheral lung adenocarcinoma Correlation with high-resolution CT findings, pathologic findings, and likelihood of tumor recurrence2009

    • Author(s)
      Iwamoto R
    • Organizer
      13^<th> world conference on lung cancer
    • Place of Presentation
      San Francisco (USA)
    • Related Report
      2010 Final Research Report
  • [Presentation] アレルギー疾患における新規の線維化機序とその重要性2008

    • Author(s)
      出原賢治
    • Organizer
      第58回日本アレルギー学会秋季学術大会
    • Place of Presentation
      東京
    • Year and Date
      2008-11-28
    • Related Report
      2010 Final Research Report
  • [Presentation] オーダーメイド医療を目指したアレルギー疾患における病因診断システムの確立2008

    • Author(s)
      出原賢治
    • Organizer
      第55回日本臨床検査医学会学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-11-28
    • Related Report
      2010 Final Research Report
  • [Presentation] アレルギー疾患におけるオーダーメイド医療2008

    • Author(s)
      出原賢治
    • Organizer
      第55回日本臨床検査医学会学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-11-28
    • Related Report
      2010 Final Research Report
  • [Presentation] オーダーメイド医療を目指したアレルギー疾患における病因診断システムの確立.2008

    • Author(s)
      出原賢治
    • Organizer
      第55回日本臨床検査医学会学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-11-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] アレルギー疾患におけるオーダーメイド医療.2008

    • Author(s)
      出原賢治
    • Organizer
      第55回日本臨床検査医学会学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-11-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] アレルギー疾患における新規の線維化機序とその重要性.2008

    • Author(s)
      出原賢治
    • Organizer
      第58回日本アレルギー学会秋季学術大会
    • Place of Presentation
      東京
    • Year and Date
      2008-11-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] アレルギー疾患免疫機序からみた一次予防のターゲットの可能性2008

    • Author(s)
      出原賢治
    • Organizer
      第58 回日本アレルギー学会秋季学術大会
    • Place of Presentation
      東京
    • Year and Date
      2008-11-27
    • Related Report
      2010 Final Research Report
  • [Presentation] アレルギー疾患免疫機序からみた一次予防のターゲットと可能性.2008

    • Author(s)
      出原賢治
    • Organizer
      第58回日本アレルギー学会秋季学術大会
    • Place of Presentation
      東京
    • Year and Date
      2008-11-27
    • Related Report
      2008 Annual Research Report
  • [Presentation] Identification of pendrin as a common mediator for mucus production in bronchial asthma and chronic obstructive pulmonary disease2008

    • Author(s)
      出原賢治
    • Organizer
      27^<th> Symposium of the Collegium Internationale Allergologicum
    • Place of Presentation
      Curacao(オランダ領アンティル(NETH))
    • Year and Date
      2008-05-04
    • Related Report
      2010 Final Research Report
  • [Presentation] Inflammation and allergy drug design and discovery.2008

    • Author(s)
      Izuhara Kenii
    • Organizer
      27th Symposium of the Collegium Internationale Allergologicum
    • Place of Presentation
      キュラソー島(オランダ領アンティル(NETH))
    • Year and Date
      2008-05-04
    • Related Report
      2008 Annual Research Report
  • [Book] 第30回六甲カンファレンス2010年における気管支喘息のすべて2011

    • Author(s)
      出原賢治, 他
    • Total Pages
      194
    • Publisher
      ライフサイエンス出版
    • Related Report
      2010 Final Research Report
  • [Book] 第30回六甲カンファレンス 2010年における気管支喘息のすべて2011

    • Author(s)
      出原賢治
    • Total Pages
      194
    • Publisher
      ライフサイエンス出版
    • Related Report
      2010 Annual Research Report
  • [Book] Environmental and Genetic factors in allergy and clinical immunology2010

    • Author(s)
      出原賢治, 他
    • Total Pages
      301
    • Publisher
      Pacini editore medicina.
    • Related Report
      2010 Final Research Report
  • [Book] 関節リウマチ(第2版)-寛解を目指す治療の新時代-2010

    • Author(s)
      出原賢治, 他
    • Total Pages
      664
    • Publisher
      日本臨牀社
    • Related Report
      2010 Final Research Report
  • [Book] Environmental and genetic factors in allergy and clinical immunology.2010

    • Author(s)
      Izuhara K
    • Total Pages
      301
    • Publisher
      Pacini editore medicina.
    • Related Report
      2010 Annual Research Report
  • [Book] 関節リウマチ(第2版)-寛解を目指す治療の新時代-2010

    • Author(s)
      出原賢治
    • Total Pages
      644
    • Publisher
      日本臨牀社
    • Related Report
      2010 Annual Research Report
  • [Book] Microarrays in inflammation2008

    • Author(s)
      出原賢治, 他
    • Total Pages
      232
    • Publisher
      Birkauser
    • Related Report
      2010 Final Research Report
  • [Book] Microarrays in Inflammation.2008

    • Author(s)
      Izuhara Kenji
    • Total Pages
      232
    • Publisher
      Birkhauser
    • Related Report
      2008 Annual Research Report
  • [Remarks] ホームページ等

    • URL

      http://www.biomol.med.saga-u.ac.jp/medbiochem/index.php

    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://www.biomol.med.saga-u.ac.jp/medbiochem/index.php

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.biomol.med.saga-u.ac.jp/medbiochem/index.php

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.biomol.med.saga-u.ac.jp/medbiochem/index.php

    • Related Report
      2008 Annual Research Report
  • [Patent(Industrial Property Rights)] ペリオスチン測定の正確性の改善方法2010

    • Inventor(s)
      出原賢治, 他
    • Industrial Property Rights Holder
      国立大学法人佐賀大学, 他
    • Filing Date
      2010-09-08
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] 増殖糖尿病網膜症の検出方法及び予防・治療剤のスクリーニング方法2010

    • Inventor(s)
      出原賢治, 他
    • Industrial Property Rights Holder
      国立大学法人佐賀大学, 他
    • Filing Date
      2010-04-14
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] 循環器病マーカーとしてのインターロイキン132010

    • Inventor(s)
      出原賢治, 他
    • Industrial Property Rights Holder
      佐賀大学, 他
    • Acquisition Date
      2010-03-05
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] 増殖糖尿病網膜症の検出方法及び予防・治療剤のスクリーニング方法2010

    • Inventor(s)
      出原賢治, 他
    • Industrial Property Rights Holder
      佐賀大学, 他
    • Industrial Property Number
      2010-093240
    • Filing Date
      2010-04-14
    • Related Report
      2010 Annual Research Report
  • [Patent(Industrial Property Rights)] ペリオスチン測定の正確性の改善方法2010

    • Inventor(s)
      出原賢治, 他
    • Industrial Property Rights Holder
      佐賀大学, 他
    • Industrial Property Number
      2010-200564
    • Filing Date
      2010-09-08
    • Related Report
      2010 Annual Research Report
  • [Patent(Industrial Property Rights)] 循環器病マーカーとしてのインターロイキン132010

    • Inventor(s)
      出原賢治, 他
    • Industrial Property Rights Holder
      国立大学法人佐賀大学, 他
    • Acquisition Date
      2010-03-05
    • Related Report
      2009 Annual Research Report
  • [Patent(Industrial Property Rights)] SCCA2濃度測定によるアレルギー疾患の検査方法2009

    • Inventor(s)
      出原賢治, 他
    • Industrial Property Rights Holder
      株式会社シノテスト
    • Filing Date
      2009-12-07
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] アレルギー疾患の検査方法2009

    • Inventor(s)
      出原賢治, 他
    • Industrial Property Rights Holder
      株式会社シノテスト
    • Filing Date
      2009-12-07
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] 胆管細胞癌の検出方法および予防・治療剤のスクリーニング方法2009

    • Inventor(s)
      出原賢治, 他
    • Industrial Property Rights Holder
      国立大学法人佐賀大学, 他
    • Filing Date
      2009-12-02
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] アトピー性皮膚炎の検出方法及び予防・治療剤のスクリーニング方法2009

    • Inventor(s)
      出原賢治
    • Industrial Property Rights Holder
      佐賀大学
    • Filing Date
      2009-07-27
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] 胆管細胞癌の検出方法および予防・治療剤のスクリーニング方法2009

    • Inventor(s)
      出原賢治, 他
    • Industrial Property Rights Holder
      国立大学法人佐賀大学, 他
    • Industrial Property Number
      2009-274873
    • Filing Date
      2009-12-02
    • Related Report
      2009 Annual Research Report
  • [Patent(Industrial Property Rights)] アレルギー疾患の検査方法2009

    • Inventor(s)
      出原賢治, 他
    • Industrial Property Rights Holder
      株式会社シノテスト
    • Industrial Property Number
      2009-298689
    • Filing Date
      2009-12-07
    • Related Report
      2009 Annual Research Report
  • [Patent(Industrial Property Rights)] SCCA2濃度測定によるアレルギー疾患の検査方法2009

    • Inventor(s)
      出原賢治, 他
    • Industrial Property Rights Holder
      株式会社シノテスト
    • Industrial Property Number
      2009-298690
    • Filing Date
      2009-12-07
    • Related Report
      2009 Annual Research Report
  • [Patent(Industrial Property Rights)] 特発性間質性肺炎の治療薬のスクリーニング方法2008

    • Inventor(s)
      出原賢治
    • Industrial Property Rights Holder
      佐賀大学
    • Filing Date
      2008-12-19
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] 特発性間質性肺炎の検出方法2008

    • Inventor(s)
      出原賢治
    • Industrial Property Rights Holder
      佐賀大学
    • Filing Date
      2008-06-05
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] 特発性間質性肺炎の検出方法2008

    • Inventor(s)
      出原賢治
    • Industrial Property Rights Holder
      佐賀大学
    • Filing Date
      2008-06-05
    • Related Report
      2008 Annual Research Report
  • [Patent(Industrial Property Rights)] アトピー性皮膚炎の治療薬2008

    • Inventor(s)
      出原賢治
    • Industrial Property Rights Holder
      佐賀大学
    • Filing Date
      2008-09-19
    • Related Report
      2008 Annual Research Report
  • [Patent(Industrial Property Rights)] 特発性間質性肺炎の治療薬のスクリーニング方法2008

    • Inventor(s)
      出原賢治
    • Industrial Property Rights Holder
      佐賀大学
    • Filing Date
      2008-12-19
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2018-02-27  

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