| Project/Area Number |
20591211
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Infectious disease medicine
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| Research Institution | Osaka Medical College |
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Principal Investigator |
UKIMURA Akira Osaka Medical College, 医学部, 教授 (50257862)
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| Co-Investigator(Kenkyū-buntansha) |
YASUSHI Kitaura 大阪医科大学, 名誉教授 (50084950)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | コクサッキーウイルス / エンテロウイルス / 心筋炎 / MDA-5 / アルドステロン / インフルエンザウイルス / 酸化ストレス |
|---|
| Research Abstract |
Enteroviruses (EV) have been implicated in the pathogenesis of DCM and myocarditis. MDA-5 expression increased in cultured cells infected with coxsakievirus B3(CVB3). Expression of mRNA of MDA5, IL-6 and IFN-γ increased in murine heart tissues infected with CVB3, and the ratio of MDA-5/RIG-I also increased. MDA-5 mRNA expression in the myocardium of EV-Positive-DCM patients is significantly higher than EV-Negative-DCM patients. The ratio of MDA-5/RIG-I in the myocardium of EV-Positive-DCM patients is significantly higher than EV-Negative-DCM patients. MDA-5 mRNA over expression or increased MDA-5/RIG-I ratio should be a marker of active replication of EV infection in DCM patients.
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