Research of new biomarkers of childhood acute encephalopathy associated with infection

• Project/Area Number: 20591225
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Pediatrics
• Research Institution: Kyushu University
• Principal Investigator: TORISU Hiroyuki Kyushu University, 大学病院, 助教 (10398076)
• Co-Investigator(Kenkyū-buntansha): KIRA Ryutaro 九州大学, 大学病院, 特別教員 (70304805) ; SANEFUJI Masafumi 九州大学, 大学病院, 助教 (50467940) ; ISHIZAKI Yoshito 九州大学, 大学病院, 助教 (20572944)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 神経科学 / 免疫学 / 脳神経疾患 / 感染症 / 小児科学

Research Abstract

To improve the prognosis of childhood acute encephalopathy associated with infection, accurate assessments followed by intensive treatments are needed at the early stage of the disease. We noticed that all patients with remarkable elevation of urinary corrected β2-microglobulin(cBMG) at the early stage had the severest neurological impairment or died. The research of the relationship between urinary cBMG at the early stage and neurological prognosis showed that the urinary cBMG of patients with the severest neurological impairment including death was statistically higher than that of recovered patients. Urinary cBMG could be a readily-measurable biomarker for the evaluation of childhood acute encephalopathy associated with infection.

Research Products

• [Journal Article] Strategy in short-term memory for pictures in childhood : A near-infrared spectroscopy study. (2011)
  • Author(s): Sanefuji M, Takada Y, Kimura N, Torisu H, et al.
  • Journal Title: Neuroimgage 54 Pages: 2394-2400
  • NAID: 120004951577
  • Peer Reviewed
• [Journal Article] Strategy in short-term memory for pictures in childhood : A near-infrared spectroscopy study (2011)
  • Author(s): Sanefuji M, Takada Y, Kimura N, Torisu H, et al.
  • Journal Title: Neuroimage Volume: 54 Pages: 2394-2400
  • NAID: 120004951577
  • Peer Reviewed
• [Journal Article] Clinical study of childhood acute disseminated encephalomyelitis, multiple sclerosis, and acute transverse myelitis in Fukuoka Prefecture (2010)
  • Author(s): Torisu H, Kira R, et al.
  • Journal Title: Japan. Brain Dev 32 Pages: 453-462
  • Peer Reviewed
• [Journal Article] Genetic susceptibility to febrile seizures : Case-control association studies. (2010)
  • Author(s): Kira R, Ishizaki Y, Torisu H, et al.
  • Journal Title: Brain Dev 32 Pages: 57-63
  • NAID: 10027212465
  • Peer Reviewed
• [Journal Article] PD1 as a common candidate susceptibility gene of subacute sclerosing panencephalitis. (2010)
  • Author(s): Ishizaki Y, Yukaya N, Kusuhara K, Kira R, Torisu H, et al.
  • Journal Title: Hum Genet 127 Pages: 417-419
  • Peer Reviewed
• [Journal Article] Clinical study of childhood acute disseminated encephalomyelitis, multiple sclerosis, and acute transverse myelitis in Fukuoka Prefecture, Japan (2010)
  • Author(s): Torisu H, Kira R, et al.
  • Journal Title: Brain Dev Volume: 32 Pages: 454-462
  • NAID: 10027491651
  • Peer Reviewed
• [Journal Article] Genetic susceptibility to febrile seizures : Case-control association studies. (2010)
  • Author(s): Kira R, Ishizaki Y, Torisu H, et al.
  • Journal Title: Brain Dev Volume: 32 Pages: 57-63
  • NAID: 10027212465
  • Peer Reviewed
• [Journal Article] PD1 as a common candidate susceptibility gene of subacute sclerosing panencephalitis. (2010)
  • Author(s): Ishizaki Y, Yukaya N, Kusuhara K, Kira R, Torisu H, et al.
  • Journal Title: Hum Genet Volume: 127 Pages: 411-419
  • Peer Reviewed
• [Journal Article] Clinical study of childhood acute disseminated encephalomyelitis, multiple sclerosis, and acute transverse myelitis in Fukuoka Prefecture, Japan (2010)
  • Author(s): Torisu H, Kira R, et al.
  • Journal Title: Brain Dev (印刷中)
  • NAID: 10027491651
  • Peer Reviewed
• [Journal Article] Genetic susceptibility to febrile seizures : case-control association studies (2010)
  • Author(s): Kira R, Ishizaki Y, Torisu H, et al
  • Journal Title: Brain Dev 32 Pages: 57-63
  • NAID: 10027212465
  • Peer Reviewed
• [Journal Article] Rhombencephalitis and coxsackievirus A16. (2009)
  • Author(s): Goto K, Sanefuji M, et al.
  • Journal Title: Emerg Infect Dis 15 Pages: 1689-1691
  • Peer Reviewed
• [Journal Article] Interleukin-10 is associated with resistance to febrile seizures : genetic association and experimental animal studies. (2009)
  • Author(s): Ishizaki Y, Kira R, et al.
  • Journal Title: Epilepsia 50 Pages: 761-767
  • Peer Reviewed
• [Journal Article] Rhombencephalitis and coxsackievirus A16 (2009)
  • Author(s): Goto K, Sanefuji M, et al.
  • Journal Title: Emerg Infect Dis 15 Pages: 1689-1691
  • Peer Reviewed
• [Journal Article] Interleukin-10 is associated with resistance to febrile seizures : genetic association and experimental animal studies (2009)
  • Author(s): Ishizaki Y, Kira R, et al
  • Journal Title: Epilepsia 50 Pages: 761-767
  • Peer Reviewed
• [Journal Article] Association of toll-like receptor 3 gene polymorphism with subacute sclerosing panencephalitis. (2008)
  • Author(s): Yoshito Ishizaki, et al.
  • Journal Title: Journal of Neurovirology 18 Pages: 1-6
  • Peer Reviewed
• [Journal Article] Epstein-Barr virus load in cerebrospinal fluid of patients with chronic active Epstein-Barr virus infection. (2008)
  • Author(s): Shoichi Ohga, et al.
  • Journal Title: The Pediatric Infectious Disease Journal 27 Pages: 1027-1030
  • Peer Reviewed
• [Journal Article] Epstein-Barr virus-associated meningoencephalomyelitis : intrathecal reactivation of the virus in an immunocompetent child. (2008)
  • Author(s): Masafumi Sanefuji, et al.
  • Journal Title: Journal of Child Neurology 23 Pages: 1072-1077
  • Peer Reviewed
• [Journal Article] Sjogren's syndrome-associated meningoencephalomyelitis : cerebrospinal fluid cytokine levels and therapeutic utility of tacrolimus. (2008)
  • Author(s): Takayuki Hoshina, et al.
  • Journal Title: Journal of the Neurological Sciences 267 Pages: 182-186
• [Journal Article] 小児急性散在性脳脊髄炎(ADEM)小児例の臨床像と疫学 (2008)
  • Author(s): 吉良龍太郎
  • Journal Title: Neuroinfection 13 Pages: 64-67
• [Journal Article] 小児急性散在性脳脊髄炎(ADEM) 小児例の臨床像と疫学. (2008)
  • Author(s): 吉良龍太郎
  • Journal Title: Neuroinfection 13 Pages: 64-67
• [Presentation] 小児の急性脳炎・脳症の臨床 (2010)
  • Author(s): 鳥巣浩幸
  • Organizer: 第462回日本小児科学会福岡地方会
  • Place of Presentation: 九州大学百年講堂(福岡市)
  • Year and Date: 2010-12-12
• [Presentation] 小児急性脳症における早期尿中β2ミクログロブリン補正値は神経学的予後に関連する (2010)
  • Author(s): 鳥巣浩幸
  • Organizer: 第52回日本小児神経学会
  • Place of Presentation: 福岡国際会議場(福岡市)
• [Presentation] ウイルス関連脳症の早期診断に関する多施設共同研究(第3報) (2010)
  • Author(s): 鳥巣浩幸
  • Organizer: 第15回日本神経感染症学会
  • Place of Presentation: 福島ビューホテル(福島市)
• [Presentation] ウイルス関連脳症の早期診断に関する多施設共同研究(第2報) (2009)
  • Author(s): 鳥巣浩幸
  • Organizer: 第14回日本神経感染症学会学術集会
  • Place of Presentation: 宇都宮市
  • Year and Date: 2009-10-17
• [Presentation] 急性の経過で、Stiff person症候群の有痛性筋痙攣と強迫行為を呈した小児の一例 (2009)
  • Author(s): 實藤雅文
  • Organizer: 第21回日本神経免疫学会学術集会
  • Place of Presentation: 大阪市
• [Presentation] 小児急性散在性脳脊髄炎、多発性硬化症の全国疫学調査(第1報)-疾患定義と一次調査- (2009)
  • Author(s): 吉良龍太郎
  • Organizer: 第21回日本神経免疫学会学術集会
  • Place of Presentation: 大阪市
• [Presentation] 急性の経過で、stiff person症候群の有痛性筋痙幸と強迫行為を呈した小児の一例 (2009)
  • Author(s): 實藤 雅文
  • Organizer: 第24回日本神経免疫学会学術集会
  • Place of Presentation: 大阪
• [Presentation] 小児急性散在性脳脊髄炎、多発性硬化症の全国疫学調査(第1報)-疾患定義と一次調査- (2009)
  • Author(s): 吉良龍太郎
  • Organizer: 第21回日本神経免疫学会学術集会
  • Place of Presentation: 大阪
• [Presentation] NIRS studies on memory : establishment of the new analysis and research for development of the memory system. (2008)
  • Author(s): 實藤雅文
  • Organizer: The 19th Fukuoka International Symposium on Pediatric/Maternal-Child Health Research.
  • Place of Presentation: Fukuoka, Japan
  • Year and Date: 2008-09-06
• [Presentation] NIRS studies on memory : establishment of the new analysis and research for development of the memory system (2008)
  • Author(s): Masafumi Sanefuji
  • Organizer: The 19th Fukuoka International Symposium on Pediatric/Maternal-Child Health Research
  • Place of Presentation: Fukuoka, Japan
  • Year and Date: 2008-09-06
• [Presentation] Genetic Susceptibility To Febrile Seizures : Case-Control Association Studies. (2008)
  • Author(s): 吉良龍太郎
  • Organizer: The 11th Annual Meeting of Infantile Seizure Society.
  • Place of Presentation: Otsu, Japan
• [Presentation] Lack of association between a polymorphism in SYN2 with genetic susceptibility to febrile seizures in Japanese. (2008)
  • Author(s): Yoshito Ishizaki.
  • Organizer: The 11th Annual Meeting of Infantile Seizure Society.
  • Place of Presentation: Otsu, Japan
• [Presentation] コクサッキーウイルスA16の手足口病に伴って菱脳炎を呈した一例 (2008)
  • Author(s): 實藤雅文
  • Organizer: 第50回日本小児神経学会総会
  • Place of Presentation: 東京都
• [Presentation] Genetic Susceptibility To Febrile Seizures : Case-Control Association Studies (2008)
  • Author(s): Ryutaro Kira
  • Organizer: The 11th Annual Meeting of Infantile Seizure Society
  • Place of Presentation: Otsu, Japan
• [Presentation] Lack of association between a polymorphism in SYN2 with genetic suscep tibility to febrile seizures in Japanese. (2008)
  • Author(s): Yoshito Ishizaki
  • Organizer: The 11th Annual Meeting of Infantile Seizure Society
  • Place of Presentation: Otsu, Japan
• [Presentation] コクサッキーウイルスA16の手足口病に伴って菱脳炎を呈した一例 (2008)
  • Author(s): 實藤 雅文
  • Organizer: 第50回日本小児神経学会総会
  • Place of Presentation: 東京
• [Book] 多発性硬化症の診断と治療:小児の急性散在性脳脊髄炎 (2008)
  • Author(s): 吉良龍太郎
  • Publisher: 新興医学出版社
• [Book] 多発性硬化症の診断と治療 : 小児の急性散在性脳脊髄炎 (分担執筆) (2008)
  • Author(s): 吉良龍太郎
  • Total Pages: 6
  • Publisher: 新興医学出版社
• [Remarks] ホームページ等 なし