Diagnosis and stem cell transplantation for inherited bone marrow failure syndrome

• Project/Area Number: 20591262
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Pediatrics
• Research Institution: Tokai University
• Principal Investigator: YABE Miharu 東海大学, 医学部, 准教授 (40172514)
• Co-Investigator(Kenkyū-buntansha): YABE Hiromasa 東海大学, 医学部, 准教授 (70220217) ; KATO Shunichi 東海大学, 医学部, 教授 (70096212)
• Project Period (FY): 2008 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
• Keywords: 先天性骨髄不全 / 造血細胞移植 / Fanconi貧血 / 遺伝子診断 / 発癌 / 妊孕能 / 骨髄不全症候群 / 染色体脆弱性 / 遺伝子検査 / 骨髄異形成症候群 / 先天性骨髄不全症候群 / 造血幹細胞移植 / ファンコニ貧血 / 身体奇形 / 白血病 / 二次癌

Research Abstract

Before March 2013, we studied 213 patients with bone marrow failure, and 95 were diagnosed as Fanconi anemia (FA) by chromosome instability and/or genetic subtypes. There were 41 congenital bone marrow failure syndrome (CBMFS) excluded FA and five had Diamond-Blackfan anemia. Three had dyskeratosis congenital and other 31 were unclassifiable CBMFS. Eighty-nine FA patients and 27 patients with CBMFS received stem cell transplantation. Significant advances have been made in the use of fludarabine-based conditioning regimen for both patients with FA and CBMFS.

Research Products

• [Journal Article] Matched sibling donor stem cell transplantation for Fanconi anemia patients with T-cell somatic mosaicism (2012)
  • Author(s): Yabe M, Shimizu T, Morimoto T, Koike T, Takakura H, Tsukamoto H, Muroi K, Oshima K, Asami K, Takata M, Yamashita T, Kato Sand Yabe H
  • Journal Title: Pediatric Transplant Volume: 16 Pages: 340-345
  • Peer Reviewed
• [Journal Article] Successful allo-HSCT with a minimal myeloablative conditioning regimen in an adult patient with Fanconi's anemia (2012)
  • Author(s): Maekawa K, Yoshimitu M, Fujiwara H, Matsushita K, Kawada H, Hamada H, Suzuki S, Uozumi K, Ohtsuka M, Hanada S, Yabe M, Yab e H and Arima N
  • Journal Title: Bone Marrow Transplantation Volume: 47 Pages: 159-160
  • Peer Reviewed
• [Journal Article] High incidence of radiation-induced cavernous hemangioma in long-term survivors who underwent hematopoietic stem cell transplantation with radiation therapy during childhood or adolescence (2012)
  • Author(s): Koike T, Yanagimachi N, Ishiguo H, Yabe H, Yabe M, MorimotoT, Shimizu T, Takakura H and Kato S
  • Journal Title: Biol Blood Marrow Transplant Volume: 18 Pages: 1119-1127
  • Peer Reviewed
• [Journal Article] Decreased serum testosterone levels in long-term adult survivors with fatty liver after childhood stem cell transplant (2012)
  • Author(s): Hyodo H, Ishiguro H, Tomita Y, Takakura h, Koike T, Shimizu T, Morimoto T, Yabe H, Yabe M, Kojima SI, Shiraishi k, Minemura T and Kato S.
  • Journal Title: Biol Blood Marrow Transplant Volume: 18 Pages: 1090-1098
  • Peer Reviewed
• [Journal Article] Matched sibling donor stem cell transplantation for Fanconi anemia patients with T-cell somatic mosaicism. Pediatric Transplant (2012)
  • Author(s): Miharu Yabe
  • Journal Title: Pediatric Transplantation Volume: 16 Pages: 340-345
  • Peer Reviewed
• [Journal Article] Systemic mastocytosis associated with t(8;21) acute myeloid leukemia in a child: Detection of the D816A mutation of KIT. (2012)
  • Author(s): Miharu Yabe
  • Journal Title: Pediatr Blood Cancer Volume: 59 Pages: 1313-1316
  • Peer Reviewed
• [Journal Article] Fanconi貧血の診断と治療 (2012)
  • Author(s): 矢部みはる
  • Journal Title: 日本小児科学会雑誌 Volume: 116 Pages: 1205-1212
  • NAID: 10030960413
• [Journal Article] リバージョン・モザイク型Fanconi貧血の診断と臨床 (2012)
  • Author(s): 矢部みはる
  • Journal Title: 日本小児血液・がん学会雑誌 Volume: 49 Pages: 251-255
• [Journal Article] Decreased serum testosterone levels in long-term adult survivors with fatty liver after childhood stem cell transplant (2012)
  • Author(s): Hyodo H, Ishiguro H, Tomita Y, Takakura h, Koike T, Shimizu T, Morimoto T, Yabe H, Yabe M, Kojima SI, Shiraishi k, Minemura T, Kato S
  • Journal Title: Biol Blood Marrow Transplan Volume: (印刷中)(Epub ahead of print)
  • Peer Reviewed
• [Journal Article] Matched sibling donor stem cell transplantation for Fanconi anemia patients with T-cell somatic mosaicism (2012)
  • Author(s): Yabe M, Shimizu T, Morimoto T, Koike T, Takakura H, Tsukamoto H, Muroi K, Oshima K, Asami K, Takata M, Yamashita T, Kato S, Yabe H
  • Journal Title: Pediatric Transplant Volume: (印刷中) Issue: 4 Pages: 340-345
  • DOI: 10.1111/j.1399-3046.2012.01669.x
  • Peer Reviewed
• [Journal Article] High incidence of fatty liver and insulin resistance in long-term adult survivors of childhood SCT (2011)
  • Author(s): Tomita Y, Ishiguro H, Yasuda Y, Hyodo H, Koike T, Shimizu T, Morimoto T, Hattori K, Matsumoto M, Inoue H, Yabe H, Yabe M, Shinohara O, Minemura T and Kato S.
  • Journal Title: Bone Marrow Transplantation Volume: 46 Pages: 416-425
  • Peer Reviewed
• [Journal Article] Alternative donor marrow transplantation in children with aplasic anemia using low-dose irradiation and fludarabine-based conditioning (2011)
  • Author(s): M Yabe, T Shimizu, T Morimoto, T Koike, H Takakura, E Suganuma, N Sugiyama, S Katoand H Yabe
  • Journal Title: Bone Marrow Transplantation Volume: 46 Pages: 1023-1025
  • Peer Reviewed
• [Journal Article] High incidence of radiation-induced cavernous hemangioma in long-term survivors who underwent hematopoietic stem cell transplantation with radiation therapy during childhood or adolescence (2011)
  • Author(s): Koike T, Yanagimachi N, Ishiguo H, Yabe H, Yabe M, Morimoto T, Shimizu T, Takakura H, Kato S
  • Journal Title: Biol Blood Marrow Transplant Volume: (印刷中)(Epub ahead of print)
  • Peer Reviewed
• [Journal Article] Therapy related myelodysplastic syndrome of recipient origin in a juvenile myelomonocytic leukemia patient 17 years after allogeneic SCT (2011)
  • Author(s): Yabe M, Morimoto T, Shimizu T, Koike T, Takakura H, Arakawa S, Kato S, Yabe H
  • Journal Title: Bone Marrow Transplantation Volume: 46 Pages: 1023-1025
  • Peer Reviewed
• [Journal Article] Alternative donor marrow transplantation in children with aplasic anemia using low-dose irradiation and fludarabine-based conditioning. Bone Marrow Transplantation (2011)
  • Author(s): Yabe M, Shimizu T, Morimoto T, Koike T, Takakura H, Suganuma E, Sugiyama N, Kato S, Yabe H.
  • Journal Title: Bone Marrow Transplantation Volume: 46 Pages: 1148-1150
  • Peer Reviewed
• [Journal Article] Precursor-T lymphoblastc lymphoma after unrelated bone marrow transplantation I a patient with Fanconi anemia (2011)
  • Author(s): Suzuki D, Yabe H, Yabe M
  • Journal Title: J Pediatr Hematol and Oncol Volume: 33 Pages: 22-24
  • Peer Reviewed
• [Journal Article] Successful allo-HSCT with a minimal myeloablative conditioning regimen in an adult patient with Fanconi's anemia. (2011)
  • Author(s): Maekawa K Yabe M, Yabe H
  • Journal Title: Bone Marrow Transplantation
  • Peer Reviewed
• [Journal Article] Rapid improvement of life-threatening capillary leak syndrome after stem cell transplantation by bevacizumab (2010)
  • Author(s): Yabe H, Yabe M, Koike T, Shimizu T, Morimoto T and Kato S.
  • Journal Title: Blood. Volume: 115 Pages: 2723-272
  • Peer Reviewed
• [Journal Article] Fertility recovery and pregnancy after allogeneic hematopoietic stem cell transplantation in Fanconi anemia patients (2010)
  • Author(s): abhan SK, Bitencourt M, Duval M, Abecasis M, Dufour C, Boudjedir K, Rocha V, Socie' G, Passweg J, Goi K, Sanders J, Snowden J, Yabe H, Pasquini R, Gluckman E
  • Journal Title: Haematologica Volume: 95 Pages: 1783-1787
  • Peer Reviewed
• [Journal Article] Natural pregnancy and delivery after unrelated bone marrow transplantation using fludarabine-based regimen in a Fanconi anemia patient (2010)
  • Author(s): Yabe H, Koike T, Shimizu T, Ishiguro H,, Kato S and Yabe M
  • Journal Title: Int J Hemato Volume: 91 Pages: 351-351
  • NAID: 10026111796
  • Peer Reviewed
• [Journal Article] Alternative donor marrow transplantation in children with aplasic anemia using low-dose irradiation and fludarabine-based conditioning. (2010)
  • Author(s): M Yabe, T Shimizu, T Morimoto, T Koike, H Takakura, E Suganuma, N Sugiyama, S Kato, H Yabe.
  • Journal Title: Bone Marrow Transplantation
  • Peer Reviewed
• [Journal Article] Rapid improvement of life-threatening capillary leak syndrome after stem cell transplantation by bevacizumab. (2010)
  • Author(s): Yabe H, Yabe M, Koike T, Shimizu T, Morimoto T, Kato S.
  • Journal Title: Blood. 115 Pages: 2723-2724
  • Peer Reviewed
• [Journal Article] Fertility recovery and pregnancy after allogeneic hematopoietic stem cell transplantation in Fanconi anemia patients. (2010)
  • Author(s): Nabhan SK, Bitencourt M, Duval M, Abecasis M, Dufour C, Boudjedir K, Rocha V, Socie' G, Passweg J, Goi K, Sanders J, Snowden J, Yabe H, Pasquini R, Gluckman E.
  • Journal Title: Haematologica 95(10) Pages: 1783-1787
  • Peer Reviewed
• [Journal Article] Natural pregnancy and delivery after unrelated bone marrow transplantation using fludarabine-based regimen in a Fanconi anemia patient. (2010)
  • Author(s): Yabe H, Koike T, Shimizu T, Ishiguro H, Kato S, Yabe M.
  • Journal Title: Int J Hemato. 91 Pages: 351-351
  • NAID: 10026111796
  • Peer Reviewed
• [Journal Article] Natural pregnancy and delivery after unrelated bone marrow transplantation using fludarabine-based regimen in a Fanconi anemia patient. (2010)
  • Author(s): Yabe H, Yabe M
  • Journal Title: Int J Hemato Volume: 91 Pages: 350-351
  • NAID: 10026111796
  • Peer Reviewed
• [Journal Article] Rapid improvement of life-threatening capillary leak syndrome after stem cell transplantation by bevacizumab. (2010)
  • Author(s): Yabe H, Yabe M
  • Journal Title: Blood Volume: 115 Pages: 2723-2724
  • Peer Reviewed
• [Journal Article] High incidence of fatty liver and insulin resistance in long-term adult survivors of childhood SCT (2010)
  • Author(s): Tomita Y, Yabe H, Yabe M
  • Journal Title: Bone Marrow Transplantation
  • Peer Reviewed
• [Journal Article] Therapy related myelodysplastic syndrome of recipient origin in a juvenile myelomonocytic leukemia patient 17 years after allogeneic SCT. (2010)
  • Author(s): Yabe M, Yabe H
  • Journal Title: Bone Marrow Transplantation
  • Peer Reviewed
• [Journal Article] Alternative donor marrow transplantation in children with aplasic anemia using low-dose irradiation and fludarabine-based conditioning.Bone Marrow Transplantation (2010)
  • Author(s): Yabe M, Yabe H
  • Journal Title: Bone Marrow Transplantation
  • Peer Reviewed
• [Journal Article] Natural pregnancy and delivery after unrelated bone marrow transplantation using fludarabine-based regimen in a Fanconi anemia patient. (2010)
  • Author(s): Yabe H, Koike T, Shimizu T, Ishiguro H, Kato S, Yabe M.
  • Journal Title: Int J Hematol 91(in press) Pages: 351-351
  • NAID: 10026111796
  • Peer Reviewed
• [Journal Article] A case of congenital bone marrow failure with radio-ulnar synostosis (2010)
  • Author(s): Yoshida H, Hashii Y, Okuda T, Kusui S, Sato E, Inoue A, Kawakami C, Yabe M, Ohta H, Ozono K.
  • Journal Title: Int J Hematol 91(in press) Pages: 331-332
  • NAID: 10026111710
  • Peer Reviewed
• [Journal Article] Fanconi anemia in infancy: report of hematopoietic stem cell transplantation to a 13-month-old patient (2009)
  • Author(s): Oshima K, Kikuchi A, Mochizuki S, Toyama D, Uchisaka N, Yabe M, Hanada R
  • Journal Title: Int J Hematol Volume: 89 Pages: 722-723
  • NAID: 10025162261
  • Peer Reviewed
• [Journal Article] Fanconi anemia in infancy : report of hematopoietic stem cell transplantation to a 13-month-old patient. (2009)
  • Author(s): Oshima K, Kikuchi A, Mochizuki S, Toyama D, Uchisaka N, Yabe M, Hanada R.
  • Journal Title: Int J Hematol. 89 Pages: 722-723
  • NAID: 10025162261
  • Peer Reviewed
• [Journal Article] Fanconi anemia in infancy : report of hematopoietic stem cell transplantation to a 13-month-old patient. (2009)
  • Author(s): Oshima K, Kikuchi A, Mochizuki S, Toyama D, Uchisaka N, Yabe M, Hanada R
  • Journal Title: Int J Hematol 89 Pages: 722-723
  • NAID: 10025162261
  • Peer Reviewed
• [Journal Article] Persistence of derivative chromosome 22 after achieving a major molecular response in chronic myeloid leukemia with a cryptic BCR-ABLI fusion gene. (2009)
  • Author(s): Matsushita H, Masukawa A, Arakawa S, Ogawa Y, Asai S, Yabe M, Ando K, Miyachi H.
  • Journal Title: Int J Hematol 90 Pages: 623-626
  • Peer Reviewed
• [Journal Article] Tacrolimus/Methotrexate versus cyclosporine/methotrexate as graft-versus-host disease prophylaxis in patients with severe aplastic anemia who received bonemarrow transplantation from unrelated donors : results of matched pair analysis (2009)
  • Author(s): Yagasaki H, Kojima S, Yabe H, Kato K, Kigasawa H, Sakamaki H, Tsuchida M, Kato S, Kawase T, Muramatsu H, Morishima Y, Kodera
  • Journal Title: Biol Blood Marrow Transplant 15 Pages: 1603-1608
  • Peer Reviewed
• [Journal Article] Risk-stratified therapy and the intensive use of cytarabine improves the outcome in childhood acute myeloid leukemia : the AML99 trial from the Japanese Childhood AML Cooperative Study Group. (2009)
  • Author(s): Tsukimoto T, Tawa A, Horibe K, Tabuchi K, Kigasawa H, Tsuchida M, Yabe H, Nakayama H, Kudo K, Kobayashi R, Hamamoto K, Imaizumi M, Morimoto A, Tsuchiya S, Hanada B
  • Journal Title: J Clin Oncol 27 Pages: 4007-4013
  • Peer Reviewed
• [Journal Article] Fanconi貧血の造血幹細胞移植 (2009)
  • Author(s): 矢部みはる
  • Journal Title: 分子細胞治療 8 Pages: 7-13
• [Journal Article] 小児期造血幹細胞移植全国集計(1983-2005)-細胞源ドナー別移植成績 (2009)
  • Author(s): 田渕健、気賀沢寿人、吉見礼美、熱田由子、足立壮一、磯山恵一、井上雅美、加藤剛二、河野嘉文、菊地陽
  • Journal Title: 日本小児血液学会雑誌 23 Pages: 142-154
  • NAID: 10029310494
• [Journal Article] 再生不良性貧血の治療-造血幹細胞移植 (2009)
  • Author(s): 矢部普正
  • Journal Title: 小児科診療 72 Pages: 295-301
• [Journal Article] 小児再生不良性貧血に対する同種造血幹細胞移植 (2009)
  • Author(s): 矢部普正
  • Journal Title: 日本小児血液学会雑誌 23 Pages: 236-243
• [Journal Article] 遺伝病とターナー症候群;ファンコニ貧血 (2009)
  • Author(s): 矢部普正
  • Journal Title: ビジュアル疾患解説 4 Pages: 4-5
• [Journal Article] (2009)
  • Author(s): 矢部みはる
  • Journal Title: 小児疾患診療のための病態生理「Fanconi貧血」(東京医学社) Pages: 1178-1182
• [Journal Article] (2009)
  • Author(s): 矢部みはる
  • Journal Title: 小児科診療ピクシス小児白血病「急性骨髄性白血病WHO分類」(中山書店) Pages: 82-87
• [Journal Article] (2009)
  • Author(s): 矢部普正
  • Journal Title: 白血病治療マニュアル改訂第3版「移植後リンパ増殖症」(南江堂) Pages: 275-277
• [Journal Article] A conditioning regimen of busulfan, fludarabine, and melphalan for allogeneic stem cell transplantation in children with juvenile myelomonocytic leukemia. (2008)
  • Author(s): Miharu Yabe
  • Journal Title: Pediatric transplantation 12 Pages: 862-867
  • Peer Reviewed
• [Presentation] 骨髄移植後閉塞性細気管支炎に対して両親よりの生体肺移植を施行した1例 (2012)
  • Author(s): 小池隆志、清水崇史、森本克、矢部みはる、矢部普正、加藤俊一、陳豊史、庄司剛、伊達洋至
  • Organizer: 第34回日本造血細胞移植学会総会
  • Place of Presentation: 大阪国際会議場(大阪)
  • Year and Date: 2012-02-25
• [Presentation] 先天性角化不全症における造血幹細胞移植の前処置の検討 (2012)
  • Author(s): 高倉広充、大坪慶輔、小池隆志、清水崇史、森本克、矢部みはる、矢部普正、加藤俊一
  • Organizer: 第34回日本造血細胞移植学会総会
  • Place of Presentation: 大阪国際会議場(大阪)
  • Year and Date: 2012-02-25
• [Presentation] 造血幹細胞移植後の長期生存者における骨密度に関する検討-女性ホルモン補充療法は骨密度を有意に改善した- (2012)
  • Author(s): 菅沼栄介、高倉広充、小池隆志、冨田雄一郎、石黒寛之、清水崇史、森本克、和泉俊一郎、矢部みはる、矢部普正、加藤俊一
  • Organizer: 第34回日本造血細胞移植学会総会
  • Place of Presentation: 大阪国際会議場(大阪)
  • Year and Date: 2012-02-25
• [Presentation] TRUMP登録されたFanconi貧血に対する造血細胞移植の検討 (2012)
  • Author(s): 矢部みはる、高橋義行、稲垣二郎、康勝好、遠藤幹也、河敬世、加藤剛二、坂巻壽、熱田由子、矢部普正
  • Organizer: 第34回日本造血細胞移植学会総会
  • Place of Presentation: 大阪国際会議場(大阪)
  • Year and Date: 2012-02-24
• [Presentation] Hematopoietic stem cell transplantation for Fanconi Anemia patients in Japan: An analysis of the registry data (2012)
  • Author(s): Yabe M, Takahashi Y, Inagaki J, Koh K, Endo M, Kawa K, Kato K, Sakamaki H, Atsuta Y, Yabe H
  • Organizer: 24th Annual Fanconi Anemia Research Fund Scientific Symposium
  • Place of Presentation: Denver, USA
• [Presentation] A fludarabine-based conditioning for alternative donor haematopoietic stem cell transplantation in inherited bone marrow failure syndrome (2012)
  • Author(s): M Yabe, H Yabe, T Shimizu, T Morimoto, T Koike, H Takakura, K Ohtsubo, A Fukumura, T Morimoto, H Yoshida, Y Ohtsuka, M Shiomi, S Kato.
  • Organizer: 38thAnnual Meeting of the European Group for Blood and Marrow Transplantation
  • Place of Presentation: Geneva
• [Presentation] Hematopoietic stem cell transplantation for Fanconi Anemia patients in Japan: An analysis of the registry data (2012)
  • Author(s): Miharu Yabe
  • Organizer: 24th Annual Fanconi Anemia Research Fund Scientific Symposium.
  • Place of Presentation: Denver
• [Presentation] リバージョン・モザイク型Fanconi貧血の診断と臨床 (2011)
  • Author(s): 矢部みはる、矢部普正
  • Organizer: 第53回日本小児血液・がん学会学術集会シンポジウム
  • Place of Presentation: ベイシア分化ホール(前橋)
  • Year and Date: 2011-11-26
• [Presentation] 著明な心機能低下を認めた再発AMLに対して2度の臍帯血移植を施行した一男児例 (2011)
  • Author(s): 大坪慶輔、清水崇史、小林真弓、高倉広充、森本克,松田晋一、神園淳司、矢部みはる、矢部普正、加藤俊一
  • Organizer: 第53回日本小児血液・がん学会学術集会
  • Place of Presentation: ベイシア分化ホール(前橋)
  • Year and Date: 2011-11-26
• [Presentation] JPLSG AML-05臨床試験におけるWHO分類に基づいた小児急性骨髄性白血病の中央診断 (2011)
  • Author(s): 木下明俊、宮地隼人、滝智彦、矢部みはる、清河信敬,照井君典、太田秀明、出口隆生、高橋浩之、多賀崇、林泰秀,多和昭雄、足立壮一
  • Organizer: 第53回日本小児血液・がん学会学術集会
  • Place of Presentation: ベイシア分化ホール(前橋)
  • Year and Date: 2011-11-25
• [Presentation] Minor bcr-ablが検出された急性巨核球性白血病の一例 (2011)
  • Author(s): 小林真弓、高倉広充、大坪慶輔、小池隆志、清水崇史、森本克、矢部みはる、矢部普正、加藤俊一
  • Organizer: 第53回日本小児血液・がん学会学術集会シンポジウム
  • Place of Presentation: ベイシア分化ホール(前橋)
  • Year and Date: 2011-11-25
• [Presentation] Clonal chromosomal aberration in Fanconi anemia patients with myelodysplasia (2011)
  • Author(s): Yabe M, Yabe H, Shimizu T, Morimoto T, Koike T, Takakura H, Otsubo K, Kato S
  • Organizer: 23^<rd> Annual Fanconi Anemia Research Fund Scientific Symposium
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2011-10-22
• [Presentation] Endocrine function in Japanese Fanconi anemia patients (2011)
  • Author(s): Yabe H, Koike T, Otsubo K, Morimoto T, Shimizu T, Takakura H, Kato S, Yabe M
  • Organizer: 23^<rd> Annual Fanconi Anemia Research Fund Scientific Symposium
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2011-10-22
• [Presentation] Alternative donor hematopoietic stem cell transplantation in inherited bone marrow failure syndrome (2011)
  • Author(s): Yabe M, Yabe H, Shimizu T, Morimoto T, Koike T, Tkakura H, Mori T, Yoshida H, Ohtsuka Y, Shiomi M, Kato S
  • Organizer: 第73回日本血液学会学術集会
  • Place of Presentation: 名古屋国際会議場(名古屋)
  • Year and Date: 2011-10-14
• [Presentation] Radiation induced cavernous hemangioma (RICH) in long term survivors who underwent BMT (2011)
  • Author(s): Koike T, Yanagimachi N, Yabe H, Yabe M, Morimoto T, Shimizu T, Ishiguro H, Takakura H, Kato S
  • Organizer: 第73回日本血液学会学術集会
  • Place of Presentation: 名古屋国際会議場(名古屋)
  • Year and Date: 2011-10-14
• [Presentation] Decreased testosterone levels in long-term adult survivors with fatty liver after childhood SCT (2011)
  • Author(s): Ishiguro H, Hyodo H, Tomita Y, Takakura H, Koike T, Shimizu T, Morimoto T, Yabe H, Ybe M, Kato S
  • Organizer: 第73回日本血液学会学術集会
  • Place of Presentation: 名古屋国際会議場(名古屋)
  • Year and Date: 2011-10-14
• [Presentation] Impact of treatment with G-CSF after allogeneic HSCT for childhood myelodysplastic syndrome (2011)
  • Author(s): Hasegawa D, Kudo K, Doisaki S, Yoshida N, Yabe M, Astuta Y, Inagaki J, Nishimura R, Inoue M, Yabe H, Kato K, Kawa K, Watanabe K
  • Organizer: 第73回日本血液学会学術集会
  • Place of Presentation: 名古屋国際会議場(名古屋)
  • Year and Date: 2011-10-14
• [Presentation] Dyskeratosis congenital : a literature and database review of immune status and stem cell transplantation data (2011)
  • Author(s): Korthof ET, van der Zalm WWWJ, Bresters D, Raohael MF, Tolar J, Bekassy A, Guengoer T, Ayas M, Albert M, Touzot F, Bacigalupo A, Fasth A, Diaz MA, Veys p, Cossu F, Yabe M, Oneto R, Perters C, Gaspar H, Dufour C, Mrsh J on behalf of the Working Parties Pediatric Diseases, Inborn Errors and Severe Aplastic Anemia
  • Organizer: 37^<th> Annual Meeting of the European Group for Blood and Marrow Transplantation
  • Place of Presentation: Paris, France
  • Year and Date: 2011-04-06
• [Presentation] Exrperience with marrow harvesting from paediatric donars at a single center : safety and efficacy (2011)
  • Author(s): Yabe M, Yabe H, Morimoto T, Shimizu T, Koiek T, Takakura H, Kato S
  • Organizer: 37^<th> Annual Meeting of the European Group for Blood and Marrow Transplantation
  • Place of Presentation: Paris, France
  • Year and Date: 2011-04-05
• [Presentation] リバージョン・モザイク型Fanconi貧血の診断と臨床 (2011)
  • Author(s): 矢部みはる、矢部普正
  • Organizer: 先天性造血不全シンポジウム
  • Place of Presentation: ホテルサンルート東京(千葉)
  • Year and Date: 2011-02-05
• [Presentation] Clonal chromosomal aberration in Fanconi anemia patients with myelodysplasia. (2011)
  • Author(s): Yabe M, Yabe H, Shimizu T, Morimoto T, Koike T, Takakura H, Otsubo K and Kato S
  • Organizer: 23rdAnnual Fanconi Anemia Research Fund Scientific Symposium
• [Presentation] Endocrine function in Japanese Fanconi anemia patients. (2011)
  • Author(s): Yabe H, Koike T, Otsubo K, Morimoto T, Shimizu T, Takakura H, Kato S and Yabe M
  • Organizer: 23rdAnnual Fanconi Anemia Research Fund Scientific Symposium.
• [Presentation] Cancer after Stem Cell Transplantation in Japanese Faconi anemia Patients. (2010)
  • Author(s): Yabe M
  • Organizer: 22nd Annual Fanconi Anemia Research Fund Scientific Symposium.
  • Place of Presentation: Minneapolis, USA
  • Year and Date: 2010-10-21
• [Presentation] Recovery of gonadal function after allogeneic stem cell transplantation for Fanconi anemia. (2010)
  • Author(s): Yabe H
  • Organizer: 22nd Annual Fanconi Anemia Research Fund Scientific Symposium.
  • Place of Presentation: Minneapolis, USA
  • Year and Date: 2010-10-21
• [Presentation] Cancer after Stem Cell Transplantation in Japanese Faconi anemia Patients (2010)
  • Author(s): Yabe M, Yabe H
  • Organizer: 22^<nd> Annual Fanconi Anemia Research Fund Scientific Symposium
  • Place of Presentation: Minneapolis, USA
  • Year and Date: 2010-10-21
• [Presentation] Recovery of gonadal function after allogeneic stem cell transplantation for Fanconi anemia. (2010)
  • Author(s): Yabe H, Yabe M
  • Organizer: 22^<nd> Annual Fanconi Anemia Research Fund Scientific Symposium
  • Place of Presentation: Minneapolis, USA
  • Year and Date: 2010-10-21
• [Presentation] Long-term follow-up after unrelated bone marrow transplantation in a patient with dyskeratosis congenita. (2010)
  • Author(s): Yabe H, Yabe M
  • Organizer: 22^<nd> Annual Fanconi Anemia Research Fund Scientific Symposium
  • Place of Presentation: Minneapolis, USA
  • Year and Date: 2010-10-21
• [Presentation] 小児・青年期発症の骨髄不全症における発癌のリスク (2010)
  • Author(s): 矢部みはる
  • Organizer: 第72回日本血液学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2010-09-25
• [Presentation] 小児・青年期発症の骨髄不全症における発癌のリスク (2010)
  • Author(s): 矢部みはる、矢部普正
  • Organizer: 第72回日本血液学会総会
  • Place of Presentation: パシフィコ横浜(神奈川)
  • Year and Date: 2010-09-25
• [Presentation] Recovery of gonadal function after allogeneic stem cell transplantation for aplastic anemia (2010)
  • Author(s): Yabe H, Yabe M
  • Organizer: 第72回日本血液学会総会
  • Place of Presentation: パシフィコ横浜(神奈川)
  • Year and Date: 2010-09-24
• [Presentation] Haematopoietic stem cell transplantationin in unclassifiable bone marrow failure syndrome with physical malformation. (2010)
  • Author(s): Miharu Yabe, Hiromasa Yabe, Satoshi, Shimizu, Tsuyoshi Morimoto, Takashi Koike, Hiromitsu Takakura, Shunichi Kato.
  • Organizer: 36th Annual Meeting of the European Group for Blood and Marrow Transplantation
  • Place of Presentation: オーストリアセンター(ウイーン)
  • Year and Date: 2010-03-22
• [Presentation] Comparison of thre preparative regimens in alternative donor transplants for aplastic anemia in Japan. (2010)
  • Author(s): Hiromasa Yabe, A.Ohara, F.Bessho, T.Nakahata, R.Kobayashi, M.Tsuchida, S.Ohga, Y.Kosaka, H.Mugishima, A.Morimoto, E.Ito, S.Kojima, on behalf of the Japan Childhood Aplastic anemia Study Group
  • Organizer: 36th Annual Meeting of the European Group for Blood and Marrow Transplantation
  • Place of Presentation: オーストリアセンター(ウイーン)
  • Year and Date: 2010-03-22
• [Presentation] 身体異常を伴う分類不能型骨髄不全症に対する造血細胞移植 (2010)
  • Author(s): 矢部みはる、矢部普正、清水崇史、森本克、小池隆志、高倉広充、松本正栄、井上裕靖、加藤俊一
  • Organizer: 第32回日本造血細胞移植学会総会
  • Place of Presentation: アクトシティ浜松(浜松)
  • Year and Date: 2010-02-20
• [Presentation] 非血縁骨髄移植後に健常児を出産したファンコニ貧血の1例 (2010)
  • Author(s): 菅沼栄介、矢部普正、矢部みはる、清水崇史、小池隆志、高倉広充、森本克、加藤俊一
  • Organizer: 第32回日本造血細胞移植学会総会
  • Place of Presentation: アクトシティ浜松(浜松)
  • Year and Date: 2010-02-19
• [Presentation] Cancer after Stem Cell Transplantation in Japanese Faconi anemia Patients (2010)
  • Author(s): Yabe M
  • Organizer: 22ndAnnual Fanconi Anemia Research Fund Scientific Symposium
• [Presentation] Allogeneic stem cell transplantation using fludarabine-based regimen for Japanese Fanconi anemia patients. (2009)
  • Author(s): Yabe H, Yabe M
  • Organizer: 第51回日本小児血液学会総会シンポジウム
  • Place of Presentation: 浦安
  • Year and Date: 2009-11-29
• [Presentation] Allogeneic stem cell transplantation using fludarabine-based regimen for Japanese Fanconi anemia patients. (2009)
  • Author(s): Hiromasa Yabe, Miharu Yabe.
  • Organizer: 第51回日本小児血液学会総会シンポジウム
  • Place of Presentation: 東京ベイホテル東急(浦安)
  • Year and Date: 2009-11-29
• [Presentation] 小児造血幹細胞移植におけるサイモグロブリンの有用性 (2009)
  • Author(s): 矢部普正
  • Organizer: 第51回日本小児血液学会総会ランチョンセミナー
  • Place of Presentation: 東京ベイホテル東急(浦安)
  • Year and Date: 2009-11-29
• [Presentation] 脂肪性肝炎を発症した急性リンパ性白血病の3例 (2009)
  • Author(s): 森本克、高倉広充、菅沼栄介、兵頭裕美、平井康太、小池隆志、池上真理子、松田晋一、清水崇史、矢部普正、矢部みはる、加藤俊一、王康雅
  • Organizer: 第51回日本小児血液学会総会
  • Place of Presentation: 東京ベイホテル東急(浦安)
  • Year and Date: 2009-11-27
• [Presentation] 多様化する造血細胞移植(2)移植方法の選択と成績 (2009)
  • Author(s): 矢部普正
  • Organizer: 第51回日本小児血液学会総会
  • Place of Presentation: 東京ベイホテル東急(浦安)
  • Year and Date: 2009-11-27
• [Presentation] Chromosomal abberation in Fanconi anemia patients with myelodysplasia. (2009)
  • Author(s): Yabe M
  • Organizer: 第71回日本血液学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 2009-10-25
• [Presentation] Chromosomal abberation in Fanconi anemia patients with myelodysplasia. (2009)
  • Author(s): Miharu Yabe, Hiromasa Yabe, Satoshi Arakawa, Takashi Shimizu, Tsuyoshi Morimoto, Takashi Koike
  • Organizer: 第71回日本血液学会学術集会
  • Place of Presentation: 京都国際会議場(京都)
  • Year and Date: 2009-10-25
• [Presentation] A fludarabine based preparative regimen in alternative stem cell transplantation for aplastic anemia. (2009)
  • Author(s): Takashi Shimizu, Hiromasa Yabe, Miharu Yabe, Tsuyoshi Morimoto.
  • Organizer: 第71回日本血液学会学術集会
  • Place of Presentation: 京都国際会議場(京都)
  • Year and Date: 2009-10-25
• [Presentation] 小児における同種造血細胞移植の現況と問題点 (2009)
  • Author(s): 矢部普正
  • Organizer: 第47回日本癌治療学会学術集会
  • Place of Presentation: パシフィコ横浜(横浜)
  • Year and Date: 2009-10-22
• [Presentation] 2. 移植後長期生存患者の体細胞における染色体不安定性 (2009)
  • Author(s): 2. 矢部みはる
  • Organizer: 第30回日本造血細胞移植学会総会
  • Place of Presentation: 札幌
  • Year and Date: 2009-02-05
• [Presentation] 染色体脆弱を有しない骨髄不全症の診断と臨床 (2008)
  • Author(s): 矢部みはる
  • Organizer: 第70回日本血液学会総会
  • Place of Presentation: 京都
  • Year and Date: 2008-10-10
• [Presentation] 再生不良性貧血に対する造血細胞移植後のTリンパ球サブセットキメリズム (2008)
  • Author(s): 矢部普正
  • Organizer: 第70回日本血液学会総会
  • Place of Presentation: 京都
  • Year and Date: 2008-10-10
• [Presentation] Allogeneic stem cell transplantation for Fanconi anemia patients with myelodysplasia and/or clonal abnormality (2008)
  • Author(s): Miharu Yabe
  • Organizer: 20^<th> annual Fanconi anemia research fund scientific symposium
  • Place of Presentation: Eugen (U. S. A)
  • Year and Date: 2008-10-04
• [Presentation] Alternative donor stem cell transplantation using fludarabine-based regimen for Japanese Fanconi anemia (2008)
  • Author(s): Hiromasa Yabe
  • Organizer: 5. 20^<th> annual Fanconi anemia research fund scientific symposium
  • Place of Presentation: Eugen (U. S. A)
  • Year and Date: 2008-10-04
• [Presentation] Fanconi貧血の臨床診断アプローチ
  • Author(s): 矢部みはる
  • Organizer: 第54回日本小児血液・がん学会学術集会
  • Place of Presentation: 横浜
  • Invited
• [Presentation] 先天性骨髄不全症候群における遺伝子解析と倫理的諸問題
  • Author(s): 矢部みはる
  • Organizer: 第54回日本小児血液・がん学会学術集会
  • Place of Presentation: 横浜
  • Invited
• [Presentation] Allogeneic HSCT for 30 children with juvenile myelomonocytic leukemia using Bu/Flu/L-PAM regimen
  • Author(s): 矢部みはる
  • Organizer: 第74回日本血液学会学術集会
  • Place of Presentation: 京都
• [Presentation] A fludarabine-based conditioning for alternative donor haematopoietic stem cell transplantation in inherited bone marrow failure syndrome.
  • Author(s): Miharu Yabe
  • Organizer: 38th Annual Meeting of the European Group for Blood and Marrow Transplantation.
  • Place of Presentation: Geneva
• [Book] Fanconi貧血 血液症候群(第2版) (2013)
  • Author(s): 矢部みはる
  • Publisher: 日本臨床社
• [Book] 新しい診断と治療のABC 72：再生不良性貧血 (2012)
  • Author(s): 矢部みはる
  • Total Pages: 228
  • Publisher: 最新医学社
• [Book] 知っておきたい内科症候群 (2012)
  • Author(s): 矢部みはる
  • Total Pages: 1516
  • Publisher: 南江堂
• [Book] 血液症候群 (2012)
  • Author(s): 矢部みはる
  • Total Pages: 535
  • Publisher: 日本臨床社
• [Book] 難治性貧血の診療ガイド:先天性骨髄不全症候群:Fanconi貧血/診療の参照ガイド (2011)
  • Author(s): 矢部みはる(分担)
  • Publisher: 南江堂
• [Book] Annual Review 血液、移植後GVHD予防としての大量シクロフォスファミドとATG (2010)
  • Author(s): 矢部普正
  • Publisher: 中外医学社
• [Book] よくわかる小児の造血細胞移植 (2010)
  • Author(s): 矢部普正
  • Publisher: 医薬ジャーナル社
• [Book] 血液診療エキスパート;貧血難治性貧血に対するfludarabineを前処置に用いた造血幹細胞移植 (2010)
  • Author(s): 矢部普正
  • Publisher: 中外医学社
• [Book] Annual Review血液 (2010)
  • Author(s): 矢部普正
  • Publisher: 中外医学社
• [Book] 血液診療エキスパート;貧血 難治性貧血に対するfludarabineを前処置に用いた造血幹細胞移植 (2010)
  • Author(s): 矢部普正
  • Publisher: 中外医学社
• [Book] 小児疾患診療のための病態生理 「Fanconi貧 血 」 (2009)
  • Author(s): 矢部みはる
  • Publisher: 東京医学社
• [Book] 小児科診療ピクシス小児白血病「急性骨髄性白血病WHO分類」 (2009)
  • Author(s): 矢部みはる
  • Publisher: 中山書店
• [Book] 小児疾患診療のための病態生理「Fanconi貧血」 (2009)
  • Author(s): 矢部みはる
  • Publisher: 東京医学社