Analysis of pathogenesis of HHV-6 encephalitis at the time of primary infection and reactivation of the virus
| Project/Area Number |
20591290
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Fujita Health University |
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Principal Investigator |
YOSHIKAWA Tetsushi Fujita Health University, 医学部, 教授 (80288472)
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| Co-Investigator(Kenkyū-buntansha) |
IHIRA Masaru 藤田保健衛生大学, 医療科学部, 准教授 (10290165)
浅野 喜造 藤田保健衛生大学, 医学部, 教授 (40131180)
菅田 健 藤田保健衛生大学, 医学部, 助教 (60454401)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | HHV-6 / 初感染 / 移植後脳炎 / サイトカイン / 再活性化 / 移植 / 脳炎 |
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| Research Abstract |
Background : Pathogenesis of human herpesvirus 6 (HHV-6) encephalitis, in particular difference between HHV-6 encephalitis at the time of primary infection and reactivation remains unclear.
Objectives : To elucidate the mechanism of HHV-6 encephalitis at the time of primary infection and reactivation.
Study design : Twenty-two HHV-6 encephalitis patients at the time of primary infection, 6 febrile convulsion (FC) patients caused by HHV-6 infection, and 14 FC patients without HHV-6 infection (non HHV-6 FC) were enrolled. Additionally, 7 stem cell transplant recipients with HHV-6 encephalitis and eight adult controls were also enrolled in this study. Cerebrospinal fluid (CSF) HHV-6 DNA copy numbers and biomarkers levels were compared.
Results : Low copy number of CSF HHV-6 DNA was detected in 7 of the 22 patients with HHV-6 encephalitis in primary infection, whereas all seven CSF samples collected from post-transplant HHV-6 encephalitis patients contained high viral DNA copy numbers (P<0.001). CSF concentrations of IL-6 (P=0.032), IL-8 (P=0.014), MMP-9 (P=0.004), and TIMP-1 (P=0.002) were significantly higher in
patients with HHV-6 encephalitis in primary infection than non-HHV-6 FC. CSF IL-6 (P=0.008), IL-8 (P=0.015), and IL-10 (P=0.019) concentrations were significantly higher in patients with post-transplant HHV-6 encephalitis than adult controls.
Conclusion : The present study suggests that the characteristics of HHV-6 encephalitis is different between HHV-6 encephalitis at the time of primary infection and reactivation in transplant recipients.
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Report
(4 results)
Research Products
(37 results)
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[Journal Article] High incidence of cytomegalovirus, human herpesvirus-6, and Epstein-Barr virus reactivation in patients receiving cytotoxic chemotherapy for Adult T cell leukemia2011
Author(s)
Ogata M, Satou T, Kawano R, Yoshikawa T, Ikewaki J, Kohno K, Ando T, Miyazaki Y, Ohtsuka E, Saburi Y, Kikuchi H, Saikawa T, Kadota J
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Journal Title
J Med Virol 83
Pages: 702-9
Related Report
Peer Reviewed
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[Journal Article] Elevated serum cytokine levels are associated with human herpesvirus 6 reactivation in hematopoietic stem cell transplantation recipients2008
Author(s)
Fujita A, Ihira M, Suzuki R, Enomoto Y, Sugiyama H, Suga S, Asano Y, Yagasaki H, Kojima S, Matsumoto K, Kato K, Yoshikawa T
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Journal Title
Related Report
Peer Reviewed
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