| Project/Area Number |
20591318
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Shinshu University |
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Principal Investigator |
MURATA Hiroshi (2010) Shinshu University, 医学部, 助教 (70262722)
高田 実 (2008-2009) Shinshu University, 医学部, 准教授 (20154784)
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| Co-Investigator(Kenkyū-buntansha) |
TAKATA Minoru 岡山大学, 医歯(薬)学総合研究科, 非常勤研究員 (20154784)
村田 浩 信州大学, 医学部, 助教 (70262722)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 悪性黒色腫 / 末梢血循環腫瘍細胞 / BRAF変異検査 / KIT遺伝子変異検査 / 個別化治療 / 薬剤耐性機序 / 腫瘍細胞の多様性 / 分子標的治療 / 末梢血液循環腫瘍細胞 / BRAF遺伝子 / Rbタンパク / KIT遺伝子 / 黒色腫 / KIT受容体 |
|---|
| Research Abstract |
To personalize the therapy with molecular targeting therapy for melanoma, we showed that : 1. two of 28 case had activating mutation of KIT gene and one of these mutation, D820Y, was sensitive to the sunitinib. 2. Circulating melanoma cells could extract by using anti-HMW-MAA antibody and we detect the BRAF mutation states from them. 3. We showed polyclonality of melanoma cells on BRAF mutation states.
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