| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
Malignant melanoma is a tumor of the poor prognosis in which the metastasis is caused at the early stage. We previously found that connexin 26 (Cx26) took an important role in the metastasis of malignant melanoma. I aimed at the development of a molecular target medicine controlling the metastasis of malignant melanoma in this study, and tried making the antibodies for the extracellular domains of the Cx26 molecule, and examined the metastasis controlling effect of the antibodies using a malignant melanoma metastasis mouse model. As a result, the antibodies showed metastasis control action although it was not strong.
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