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Study of the role of connexin 26 in metastasis of malignant melanoma and development of metastasis inhibitor

Research Project

Project/Area Number 20591325
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Dermatology
Research InstitutionNara Medical University

Principal Investigator

ASADA Hideo  Nara Medical University, 医学部, 教授 (60252681)

Co-Investigator(Renkei-kenkyūsha) ITO Akihiko  近畿大学, 医学部, 教授 (80273647)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords悪性黒色腫 / コネキシン26 / ギャップ結合 / 転移 / 内皮細胞
Research Abstract

Malignant melanoma is a tumor of the poor prognosis in which the metastasis is caused at the early stage. We previously found that connexin 26 (Cx26) took an important role in the metastasis of malignant melanoma. I aimed at the development of a molecular target medicine controlling the metastasis of malignant melanoma in this study, and tried making the antibodies for the extracellular domains of the Cx26 molecule, and examined the metastasis controlling effect of the antibodies using a malignant melanoma metastasis mouse model. As a result, the antibodies showed metastasis control action although it was not strong.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (17 results)

All 2011 2010 2009 2008

All Journal Article (9 results) (of which Peer Reviewed: 8 results) Presentation (8 results)

  • [Journal Article] Repair pathways independent of the Fanconi anemia nuclear core complex play a predominant role in mitigating formaldehyde-induced DNA damage.2011

    • Author(s)
      Noda T, Takahashi A, Kondo N, Mori E, Okamoto N, Nakagawa Y, Ohnishi K, Zdzienicka MZ, Thompson LH, Helleday T, Asada H, Ohnishi T
    • Journal Title

      Biochem Biophys Res Commun 404

      Pages: 206-210

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Repair pathways independent of the Fanconi anemia nuclear core complex play a predominant role in mitigating formaldehyde-induced DNA damage.2010

    • Author(s)
      Noda T, et al
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 404 Pages: 206-210

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 下肢の生じたStewart-Treves症候群の1例2009

    • Author(s)
      森戸啓統、泉敦子、井本恭子、福本隆也、小林信彦、浅田秀夫、宮川幸子、浅川勇雄、榎本美生、多田英之
    • Journal Title

      皮膚臨床 51

      Pages: 1065-1068

    • Related Report
      2010 Final Research Report
  • [Journal Article] High ratio of IgG4-positive plasma cell infiltration in cutaneous plasmacytosis--is this a cutaneous manifestation of IgG4-related disease?2009

    • Author(s)
      Miyagawa-Hayashino A, et al
    • Journal Title

      Hum Pathol 40

      Pages: 1269-1277

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 下肢の生じた Stewart-Treves 症候群の1例2009

    • Author(s)
      森戸啓統, 他
    • Journal Title

      皮膚科の臨床 51

      Pages: 1065-1068

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 小児の lymphomatoid papulosis2009

    • Author(s)
      大黒奈津子, 他
    • Journal Title

      皮膚病診療 31

      Pages: 605-608

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relationship among human herpesvirus 6 reactivation. serum interleukin-10 levels, and skin rash / GVHD after allogeneic stem cell transplantation.2008

    • Author(s)
      Kitamura K, Asada H, et al
    • Journal Title

      J Am Acad Dermatol 58

      Pages: 802-809

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulatory effects of antihistamines on the responses to staphylococcal enterotoxin B of human monocyte-derived dendritic cells and CD4+T cells.2008

    • Author(s)
      Iida H, Asada H, et al
    • Journal Title

      J Dermatol Sci 52

      Pages: 31-38

    • NAID

      10024457226

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Adjuvant effect of lipopolysaccharide on the induction of contact hypersensitivity to haptens in mice.2008

    • Author(s)
      Yokoi S, Niizeki H, Iida H, Asada H, et al
    • Journal Title

      J Dermatol Sci 53

      Pages: 120-128

    • NAID

      10025332380

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 青色母斑やpigmented epithelioid melanocytomaとの鑑別が問題となったmelanomaの1例2010

    • Author(s)
      大黒奈津子, 他
    • Organizer
      第74回日本皮膚科学会東部支部学術大会
    • Place of Presentation
      宮城県
    • Year and Date
      2010-11-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] Pigmented lesion on the right sole, nodular melanoma with massive regression2010

    • Author(s)
      Fukumoto T, et al
    • Organizer
      第2回Professor Mihm's Dermatopathology
    • Place of Presentation
      東京都
    • Year and Date
      2010-08-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] 腹部皮下に発生した悪性末梢神経腫瘍の1例2010

    • Author(s)
      飯岡弘至, 他
    • Organizer
      第26回日本皮膚悪性腫瘍学会学術大会
    • Place of Presentation
      東京都
    • Year and Date
      2010-06-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] Pigmented lesion on the right sole, nodular melanoma with massive regression.2010

    • Author(s)
      Fukumoto T, Daikoku N, Kuwahara T, Kobayasi N, Asada H
    • Organizer
      Professor Mihm's Dermatopathology
    • Place of Presentation
      Tokyo
    • Related Report
      2010 Final Research Report
  • [Presentation] 青色母斑やpigmented epithelioid melanocytomaとの鑑別が問題となったmelanomaの1例2010

    • Author(s)
      大黒奈津子、伊東由美子、長谷川文子、飯岡弘至、福本隆也、浅田秀夫
    • Organizer
      第74回日本皮膚科学会東部支部学術大会
    • Place of Presentation
      宮城
    • Related Report
      2010 Final Research Report
  • [Presentation] 腹部皮下に発生した悪性末梢神経腫瘍の1例2010

    • Author(s)
      飯岡弘至、長山功佑、小川浩平、九鬼千夏、真名子英理、野田太一、桑原理充、福本隆也、浅田秀夫
    • Organizer
      第26回日本皮膚悪性腫瘍学会学術大会
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report
  • [Presentation] 大腿部の褐色結節2009

    • Author(s)
      福本隆也、小川浩平、中野さち子、森戸啓統、北村華奈、浅田秀夫
    • Organizer
      第60回日本皮膚科学会中部支部学術大会
    • Place of Presentation
      京都
    • Related Report
      2010 Final Research Report
  • [Presentation] 大腿部の黒褐色腫瘍2008

    • Author(s)
      福本隆也、白山純実、真柴久美、桑原理充、岡崎愛子、浅田秀夫
    • Organizer
      第59回日本皮膚科学会中部支部学術大会
    • Place of Presentation
      名古屋
    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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