| Project/Area Number |
20591353
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Dermatology
|
|---|
| Research Institution | Juntendo University |
|---|
Principal Investigator |
NIYONSABA Francois Juntendo University, 大学院・医学研究科, 准教授 (60365640)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
牛尾 博子 順天堂大学, 大学院・医学研究科, 准教授 (30317391)
ホク モハメドイムラヌル 順天堂大学, 大学院・医学研究科, 研究員 (80586363)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Keywords | ケラチノサイト / Psoriasin / Dermcidin / 殺菌物質 / サイトカイン・ケモカイン / 自然免疫 / 感染防御 |
|---|
| Research Abstract |
In addition to human β-defensins and LL-37, the cutaneous tissue also generates other antimicrobial agents, including psoriasin, dermcidin and catestatin. In this study project, we found that above antimicrobial agents activate and regulate various functions of human keratinocytes and mast cells. Thus, besides their microbiocidal properties, skin-derived antimicrobial agents might also participate in cutaneous host defense, inflammation and innate immune system.
|
