Roles of antimicrobial agents Psoriasin and Dermcidin in skin innate immunity

• Project/Area Number: 20591353
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Dermatology
• Research Institution: Juntendo University
• Principal Investigator: NIYONSABA Francois Juntendo University, 大学院・医学研究科, 准教授 (60365640)
• Co-Investigator(Kenkyū-buntansha): 牛尾 博子 順天堂大学, 大学院・医学研究科, 准教授 (30317391) ; ホク モハメドイムラヌル 順天堂大学, 大学院・医学研究科, 研究員 (80586363)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: ケラチノサイト / Psoriasin / Dermcidin / 殺菌物質 / サイトカイン・ケモカイン / 自然免疫 / 感染防御

Research Abstract

In addition to human β-defensins and LL-37, the cutaneous tissue also generates other antimicrobial agents, including psoriasin, dermcidin and catestatin. In this study project, we found that above antimicrobial agents activate and regulate various functions of human keratinocytes and mast cells. Thus, besides their microbiocidal properties, skin-derived antimicrobial agents might also participate in cutaneous host defense, inflammation and innate immune system.

Research Products

• [Journal Article] Catestatin, a neuroendocrine antimicrobial peptide, induces human mast cell migration, degranulation and production of cytokines and chemokines. (2011)
  • Author(s): Aung G, Niyonsaba F, Ushio H, Kajiwara N, Saito H, Ikeda S, Ogawa H, Okumura K.
  • Journal Title: Immunology 132 Pages: 527-39
  • Peer Reviewed
• [Journal Article] A neuroendocrine antimicrobial peptide, catestatin, stimulates interleukin-8 production from human keratinocytes via activation of mitogen-activated protein kinases. (2011)
  • Author(s): Aung G, Niyonsaba F, Ushio H, Hoq MI, Ikeda S, Ogawa H, Okumura K.
  • Journal Title: J Dermatol Sci 61 Pages: 142-4
  • NAID: 10030890215
  • Peer Reviewed
• [Journal Article] Catestatin, a neuroendocrine antimicrobial peptide, induces human mast cell migration, degranulation and production of cytokines and chemokines. (2011)
  • Author(s): Aung U, Niyonsaba F., et al.
  • Journal Title: Immunology Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] Antimicrobial peptides human β-defensins and cathelicidin LL-37 induce the secretion of a pruritogenic cytokine interleukin-31 by human mast cells. (2010)
  • Author(s): Niyonsaba F, Ushio H, Hara M, Yokoi H, Tominaga M, Takamori K, Kajiwara N, Saito H, Nagaoka I, Ogawa H, Okumura K.
  • Journal Title: J Immunol 184 Pages: 3526-34
  • Peer Reviewed
• [Journal Article] Antimicrobial peptides human β-defensins and cathelicidin LL-37 induce the secretion of a pruritogenic cytokine interleukin-31 by human mast cells (2010)
  • Author(s): Francois Niyonsaba, et al.
  • Journal Title: Journal of Immunology (印刷中)
  • Peer Reviewed
• [Journal Article] The human antimicrobial peptide dermcidin activates normal human keratinocytes. (2009)
  • Author(s): Niyonsaba F, Suzuki A, Ushio H, Nagaoka I, Ogawa H, Okumura K.
  • Journal Title: Br J Dermatol 160 Pages: 243-9
  • Peer Reviewed
• [Journal Article] The human antimicrobial peptide dermcidin activates normal human keratinocytes. (2009)
  • Author(s): Francois Niyonsaba
  • Journal Title: British Journal of Dermatology 160 (2) Pages: 243-249
  • Peer Reviewed
• [Presentation] A neuroendocrine antimicrobial peptide, catestatin, activates multiple functions in human mast cells. (2010)
  • Author(s): Aung G, Niyonsaba F, Ushio H, Okumura K, Ogawa H, Ikeda S.
  • Organizer: 日本研究皮膚科学会第35回年次学術大会・総会
  • Place of Presentation: 和歌山
  • Year and Date: 2010-12-04
• [Presentation] Catestatins activate human mast cells. (2010)
  • Author(s): Aung G, Niyonsaba F, Ushio H, Ikeda S, Ogawa H, Okumura K.
  • Organizer: 第60日本アレルギー学会
  • Place of Presentation: 東京
  • Year and Date: 2010-11-25
• [Presentation] Evaluation of the effects of α-defensins a human neutrophil peptides on neutrophil apoptosis. (2010)
  • Author(s): Nagaoka I, Suzuki K, Murakami T, Niyonsaba F, Tamura H, Hirata M.
  • Organizer: Annual Meeting of the Society for Leukocyte Biology & the International Endotoxin and Innate Immunity Society
  • Place of Presentation: Vancouver, Canada
  • Year and Date: 2010-10-09
• [Presentation] Synthetic innate defense regulator (IDR) peptides IDR-HH2, IDR-1002 and IDR-1018 modulate various functions of human neutrophils. (2010)
  • Author(s): Niyonsaba F, Madera L, Hancock RE.
  • Organizer: Annual Meeting of the Society for Leukocyte Biology & the International Endotoxin and Innate Immunity Society
  • Place of Presentation: Vancouver, Canada
  • Year and Date: 2010-10-08
• [Presentation] A neuroendocrine antimicrobial peptide, catestatin, activates multiple functions inhuman mast cells (2010)
  • Author(s): Aung G., Niyonsaba F.
  • Organizer: 日本アレルギー学会
  • Place of Presentation: 東京
• [Presentation] Catestatins activate human mast cells (2010)
  • Author(s): Aung G., Niyonsaba F.
  • Organizer: 日本研究皮膚科学会
  • Place of Presentation: 和歌山
• [Presentation] 抗菌ペプチドβ-デフェンシンとLL-37のヒトマスト細胞からのVEGF産生に及ぼす影響 (2009)
  • Author(s): Niyonsaba F, 牛尾博子, Aung Gyi, 小川秀興, 奥村康
  • Organizer: 第39日本免疫学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2009-12-04
• [Presentation] Human β-defensins and cathelicidin LL-37 on VEGF production in human mast cells. (2009)
  • Author(s): Niyonsaba F, 牛尾博子, 小川秀興, 奥村康
  • Organizer: 第59日本アレルギー学会
  • Place of Presentation: 秋田
  • Year and Date: 2009-10-31
• [Presentation] The antimicrobial human β-defensins mediate secretion of pruritogenic factors in human mast cells. (2009)
  • Author(s): Niyonsaba F, Ushio H, Nagaoka I, Ogawa H, Okumura K.
  • Organizer: Tri-Society Annual Conference 2009 of the Society for Leukocyte Biology, International Cytokine Society, and International Society for Interferon and Cytokine Research
  • Place of Presentation: Lisbon, Portugal
  • Year and Date: 2009-10-21
• [Presentation] Human β-defensins and cathelicidin LL-37 increase IL-31 production in human mast cells. (2008)
  • Author(s): Niyonsaba F, 牛尾博子, 小川秀興, 奥村康
  • Organizer: 第38日本免疫学会総会
  • Place of Presentation: 京都
  • Year and Date: 2008-12-02
• [Presentation] Human β-defensins and cathelicidin LL-37 on IL-31 production in human mast cells. (2008)
  • Author(s): Niyonsaba F, Ushio H, Ogawa H, Okumura K.
  • Organizer: 第58日本アレルギー学会
  • Place of Presentation: 東京
  • Year and Date: 2008-11-27
• [Presentation] Endogenous antimicrobial peptides human β-defensins and cathelicidin LL-37 increase IL-31 production in human mast cells. (2008)
  • Author(s): Niyonsaba F.
  • Organizer: The 10^<th> China-Japan Joint Meeting of Dermatology
  • Place of Presentation: Hangzhou, China
  • Year and Date: 2008-10-31