Elucidation of penetration mechanisms of sensory nerve fibers on a basement membrane in atopic dermatitis and application to intractable pruritus

• Project/Area Number: 20591354
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Dermatology
• Research Institution: Juntendo University
• Principal Investigator: TAKAMORI Kenji Juntendo University, 医学部, 特任教授 (40053144)
• Co-Investigator(Kenkyū-buntansha): TOMINAGA Mitsutoshi 順天堂大学, 医学研究科, 研究員 (50468592)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 痒み / 知覚神経 / アトピー性皮膚炎 / 細胞外マトリックス / MMP-2 / MMP-8 / 難治性痒み / 知覚神経線維 / 真皮 / Sema3A / NGF / コラーゲン / 基底膜

Research Abstract

This study was performed to investigate mechanisms of penetration of sensory nerve fibres into the basement membrane of the skin. A rat dorsal root ganglion neuron culture system consisting of Matrigel and a Boyden chamber containing a nerve growth factor (NGF) concentration gradient was used, and membrane-associated MMP-2 contributes to penetration of nerve fibres into Matrigel through modulation by axonal guidance molecules and/or extracellular matrix components. Another study was performed to investigate elongation mechanisms of dermal nerve fibers within interstitial collagen matrix. Our study using the neuron culture system suggested that MMP-8 is involved in sensory nerve growth within interstitial collagen matrix.

Research Products

• [Journal Article] Inhibitory effects of UV-based therapy on dry skin-inducible nerve growth in acetone-treated mice. (2011)
  • Author(s): Kamo A, Tominaga M, Negi O, Tengara S, Taneda K, Ogawa H, Takamori K
  • Journal Title: J Dermatol Sci. (in press)
  • NAID: 10030891073
  • Peer Reviewed
• [Journal Article] Topical application of emollients prevent dry skin-inducible intraepidermal nerve growth in acetone-treated mice. (2011)
  • Author(s): Kamo A, Tominaga M, Negi O, Tengara S, Taneda K, Ogawa H, Takamori K
  • Journal Title: J Dermatol Sci. (in press)
  • Peer Reviewed
• [Journal Article] Recent advances in pathophysiological mechanisms of itch. (2010)
  • Author(s): 冨永光俊, 高森建二
  • Journal Title: Expert Rev Dermatol. 5 Pages: 197-212
  • Peer Reviewed
• [Journal Article] Molecular expression of Ly6K, a putative glycosylphosphatidy-inositol-anchored membrane protein on the mouse testicular germ cell (2010)
  • Author(s): Maruyama M, Yoshitake H, Tsukamoto H, Takamori K, Araki Y.
  • Journal Title: Biochem Biophys Res Commum 402 Pages: 75-81
  • Peer Reviewed
• [Journal Article] Keratinocyte-derived anosmin-1, an extracellular glycoprotein encoded by X-linked Kallmann syndrome gene, is involved in modulation of epidermal nerve density in atopic dermatitis. (2010)
  • Author(s): Tengara S, Tominaga M, Kamo A, Taneda K, Negi O, Ogawa H, Takamori K
  • Journal Title: J Dermatol Sci. 58 Pages: 64-71
  • NAID: 10027400427
  • Peer Reviewed
• [Journal Article] Antimicrobial peptides human beta-defensins and cathelicidin LL-37 induce the secretion of a pruritogenic cytokine interleukin-31 by human mast cells. (2010)
  • Author(s): Niyonsaba F, Ushio H, Hara M, Yokoi H, Tominaga M, Takamori K, Kajiwara N, Saito H, Nagaoka I, Ogawa H, Okumura K.
  • Journal Title: J Immunol. 184 Pages: 3526-34
  • Peer Reviewed
• [Journal Article] Neurotropin inhibits both capsaicin-induced substance P release and nerve growth factor-induced neurite outgrowth in cultured rat dorsal root ganglion neurones. (2010)
  • Author(s): Taneda K, Tominaga M, Tengara S, Ogawa H, Takamori K
  • Journal Title: Clin Exp Dermatol. 35 Pages: 73-77
  • Peer Reviewed
• [Journal Article] Effect of a novel kappa-receptor agonist, nalfurafine hydrochloride, on severe itch in 337 haemodialysis patients : a Phase III, randomized, double-blind, placebo-controlled study. (2010)
  • Author(s): Kumagai H, Ebata T, Takamori K, Muramatsu T, Nakamoto H, Suzuki H.
  • Journal Title: Nephrol Dial Transplant. 25 Pages: 1251-1257
  • Peer Reviewed
• [Journal Article] Significance of glycosphingolipid fatty acid chain length on membrane microdomain-mediated signal transduction. (2010)
  • Author(s): Iwabuchi K, Nakayama H, Iwahara C, Takamori K
  • Journal Title: FEBS Lett. 584 Pages: 1642-52
  • Peer Reviewed
• [Journal Article] Mass spectrometric identification of tryptophan nitration sites on proteins in peroxynitrite-treated lysates from PC12 cells. (2010)
  • Author(s): Kawasaki H, Ikeda K, Shigenaga A, Baba T, Takamori K, Ogawa H, Yamakura F.
  • Journal Title: Free Radic Biol Med. (in press)
  • Peer Reviewed
• [Journal Article] Recent advances in pathophysiological mechanisms of itch (2010)
  • Author(s): Tominaga M, Takamori K
  • Journal Title: Expert Rev Dermatol Volume: 5 Pages: 197-212
  • Peer Reviewed
• [Journal Article] Keratinocyte-derived anosmin-1, an extracellular glycoprotein encoded by X-linked Kallmann syndrome gene, is involved in modulation of epidermal nerve density in atopic dermatitis (2010)
  • Author(s): Tengara S, Tominaga M, Kamo A, Taneda K, Negi O, Ogawa H, Takamori K
  • Journal Title: J Dermatol Sci Volume: 58 Pages: 64-71
  • NAID: 10027400427
  • Peer Reviewed
• [Journal Article] Antimicrobial peptides human beta-defensins and cathelicidin LL-37 induce the secretion of a pruritogenic cytokine interleukin-31 by human mast cells (2010)
  • Author(s): Niyonsaba F, Ushio H, Hara M, Yokoi H, Tominaga M, Takamori K, Kajiwara N, Saito H, Nagaoka I, Ogawa H, Okumura K
  • Journal Title: J Immunol Volume: 184 Pages: 3526-3534
  • Peer Reviewed
• [Journal Article] Equatorin : identification and characterization of the epitope of the MN9 antibody in the mouse. (2009)
  • Author(s): Yamatoya K, Yoshida K, Ito C, Maekawa M, Yanagida M, Takamori K, Ogawa H, Araki Y, Miyado K, Toyama Y, Toshimori K.
  • Journal Title: Biol Reprod. 81 Pages: 889-97
  • Peer Reviewed
• [Journal Article] Changes in the gene expression of peripheral blood mononuclear cells during the menstrual cycle of females is associated with a gender bias in the incidence of systemic lupus erythematosus. (2009)
  • Author(s): Kawasaki M, Sekigawa I, Nozawa K, Kaneko H, Takasaki Y, Takamori K, Ogawa H.
  • Journal Title: Clin Exp Rheumatol. 27 Pages: 260-6
  • Peer Reviewed
• [Journal Article] Autoantibody to NA14 is an independent marker primarily for Sjogren's syndrome. (2009)
  • Author(s): Nozawa K, Ikeda K, Satoh M, Reeves WH, Stewart CM, Li YC, Yen TJ, Rios RM, Takamori K, Ogawa H, Sekigawa I, Takasaki Y, Chan EK.
  • Journal Title: Front Biosci. 14 Pages: 3733-9
  • Peer Reviewed
• [Journal Article] Distribution of molecular epitope for Ts4, an anti-sperm auto-monoclonal antibody in the fertilization process. (2009)
  • Author(s): Shirai Y, Yoshitake H, Maruyama M, Takamori K, Ogawa H, Hasegawa A, Araki Y.
  • Journal Title: J Reprod Dev. 55 Pages: 240-6
  • NAID: 10024942147
  • Peer Reviewed
• [Journal Article] In vitro model for penetration of sensory nerve fibers on a Matrigel basement membrane : Implications for possible application to intractable pruritus. (2009)
  • Author(s): Tominaga M, Kamo A, Tengara S, Ogawa H, Takamori K
  • Journal Title: Br J Dermatol. 161 Pages: 1028-1037
  • Peer Reviewed
• [Journal Article] ABCA12 is a major causative gene for non-bullous congenital ichthyosiform erythroderma. (2009)
  • Author(s): Sakai K, Akiyama M, Yanagi T, McMillan JR, Suzuki T, Tsukamoto K, Sugiyama H, Hatano Y, Hayashitani M, Takamori K, Nakashima K, Shimizu H.
  • Journal Title: J Invest Dermatol. 129 Pages: 2306-9
  • Peer Reviewed
• [Journal Article] Histological characterization of cutaneous nerve fibers containing gastrin-releasing peptide in atopic dermatitis. (2009)
  • Author(s): Tominaga M, Ogawa H, Takamori K
  • Journal Title: J Invest Dermatol. 129 Pages: 2901-2905
  • Peer Reviewed
• [Journal Article] Psoralen-ultraviolet A therapy alters epidermal Sema3A and NGF levels and modulates epidermal innervation in atopic dermatitis. (2009)
  • Author(s): Tominaga M, Tengara S, Kamo A, Ogawa H, Takamori K
  • Journal Title: J Dermatol Sci. 55 Pages: 40-46
  • NAID: 10025334220
  • Peer Reviewed
• [Journal Article] The penetartion mechanisms of nerve fibers into the epidermis of atopic dermatitis. (2009)
  • Author(s): 冨永光俊, 高森建二
  • Journal Title: J Environ Dermatol Cutan Allergol. Vol.3 No.2 Pages: 70-77
  • Peer Reviewed
• [Journal Article] Epithelial-specific requirement of FGFR2 signaling during tooth and palate development. (2009)
  • Author(s): Hosokawa R, Deng X, Takamori K, Xu X, Urata M, Bringas P Jr, Chai Y.
  • Journal Title: J Exp Zoolog, Mol Dev Evol 312B(4) Pages: 343-350
  • Peer Reviewed
• [Journal Article] In vitro model for penetration of sensory nerve fibers on a Matrigel basement membrane : Implications for possible application to intractable pruritus (2009)
  • Author(s): Tominaga M, Kamo A, Tengara S, Ogawa H, Takamori K
  • Journal Title: British Journal of Dermatology 161 Pages: 1028-1037
  • Peer Reviewed
• [Journal Article] Histological characterization of cutaneous nerve fibers containing gastrin-releasing peptide in NC/Nga mice : an atopic dermatitis model (2009)
  • Author(s): Tominaga M, Ogawa H, Takamori K
  • Journal Title: Journal of Investigative Dermatology 129 Pages: 2901-2905
  • Peer Reviewed
• [Journal Article] Psoralen-ultraviolet A therapy alters epidermal Sema3A and NGF levels and modulates epidermal innervation in atopic dermatitis (2009)
  • Author(s): Tominaga M, Tengara S, Kamo A, Ogawa H, Takamori K
  • Journal Title: Journal of Dermatological Science 55 Pages: 40-46
  • NAID: 10025334220
  • Peer Reviewed
• [Journal Article] Decreased production of semaphorin 3A in the lesional skin of atopic dermatitis. (2008)
  • Author(s): Tominaga M, Ogawa H, Takamori K
  • Journal Title: Br J Dermatol. 158 Pages: 842-844
  • Peer Reviewed
• [Journal Article] Genotype-phenotype correlations in six Japanese patients with recessive dystrophic epidermolysis bullosa with the recurrent p.Glu2857X mutation. (2008)
  • Author(s): Saito M, Masunaga T, Teraki Y, Tominaga M, Ishiko A.
  • Journal Title: J Dermatol Sci. 52 Pages: 13-20
  • Peer Reviewed
• [Journal Article] Status of plasmapheresis for the treatment of toxic epidermal necrolysis in Japan. (2008)
  • Author(s): Yamada H, Tominaga M
  • Journal Title: Ther Apher Dial. 12 Pages: 355-9
  • Peer Reviewed
• [Journal Article] Molecular diversity of TEX101, a marker glycoprotein for germ cells monitored with monoclonal antibodies : Variety of the molecular characteristics according to subcellular localization within the mouse testis. (2008)
  • Author(s): Yoshitake H, Shirai Y, Mochizuki Y, Iwanari H, Tsubamoto H, Koyama K, Tominaga M, Ogawa H, Hasegawa A, Kodama T, Hamakubo T, Araki Y.
  • Journal Title: J Reprod Immunol. 79 Pages: 1-11
  • Peer Reviewed
• [Journal Article] Protein biomarker analysis by mass spectrometry in patients with rheumatoid arthritis receiving anti-tumor necrosis factor-alpha antibody therapy. (2008)
  • Author(s): Sekigawa I, Yanagida M, Iwabuchi K, Kaneda K, Kaneko H, Takasaki Y, Jung G, Sone S, Tanaka Y, Ogawa H, Tominaga M
  • Journal Title: Clin Exp Rheumatol. 26 Pages: 261-7
  • Peer Reviewed
• [Journal Article] TEX101, a germ cell-marker glycoprotein, is associated with lymphocyte antigen 6 complex locus k within the mouse testis. (2008)
  • Author(s): Yoshitake H, Tsukamoto H, Maruyama-Fukushima M, Takamori K, Ogawa H, Araki Y.
  • Journal Title: Biochem Biophys Res Commun. 372 Pages: 277-82
  • Peer Reviewed
• [Journal Article] Detection of serum IgE class anti-SSA antibodies in mothers with foetal loss. (2008)
  • Author(s): Sekigawa I, Kaneda K, Kaneko H, Takasaki Y, Takamori K, Ogawa H.
  • Journal Title: Rheumatol Int. 28 Pages: 623-6
  • Peer Reviewed
• [Journal Article] Role of glycosphingolipid-enriched microdomains in innate immunity : microdomain-dependent phagocytic cell functions. (2008)
  • Author(s): Yoshizaki F, Nakayama H, Iwahara C, Takamori K, Ogawa H, Iwabuchi K.
  • Journal Title: Biochim Biophys Acta. 1780 Pages: 383-92
  • Peer Reviewed
• [Journal Article] Lyn-coupled LacCer-enriched lipid rafts are required for CD11b/CD18-mediated neutrophil phagocytosis of nonopsonized microorganisms. (2008)
  • Author(s): Nakayama H, Yoshizaki F, Prinetti A, Sonnino S, Mauri L, Takamori K, Ogawa H, Iwabuchi K.
  • Journal Title: J Leukoc Biol. 83 Pages: 728-41
  • Peer Reviewed
• [Journal Article] Involvement of very long fatty acid-containing lactosylceramide in lactosylceramide-mediated superoxide generation and migration in neutrophils. (2008)
  • Author(s): Iwabuchi K, Prinetti A, Sonnino S, Mauri L, Kobayashi T, Ishii K, Kaga N, Murayama K, Kurihara H, Nakayama H, Yoshizaki F, Takamori K, Ogawa H, Nagaoka I.
  • Journal Title: Glycoconj J. 5 Pages: 357-74
  • Peer Reviewed
• [Journal Article] Decreased production of semaphorin 3A in the lesional skin of atopic dermatitis (2008)
  • Author(s): Tominaga M
  • Journal Title: British Journal of Dermatology 158 Pages: 842-844
  • Peer Reviewed
• [Journal Article] アトピー性皮膚炎のバリア機能異常と痒みの関係 (2008)
  • Author(s): 高森建二
  • Journal Title: アレルギーの臨床 28 Pages: 28-33
  • Peer Reviewed
• [Presentation] 光線療法による表皮内神経の制御-アトピー性皮膚炎の痒みについて- (2010)
  • Author(s): 冨永光俊
  • Organizer: 第109回日本皮膚科学会総会
  • Place of Presentation: 大阪
• [Presentation] (2010)
  • Author(s): 冨永光俊, 高森建二
  • Organizer: Intractable itch and nerve fibers-Penetration mechanisms of nerve fibers into epidermis-Neuro2010
  • Place of Presentation: Kobe, Japan
• [Presentation] アトピー性皮膚炎の痒みのメカニズムに関する研究-表皮内神経線維の制御機構- (2010)
  • Author(s): 冨永光俊
  • Organizer: 第40回日本皮膚アレルギー・接触皮膚炎学会総会・学術大会
  • Place of Presentation: 広島
• [Presentation] アトピー性皮膚炎の痒みの機序 (2010)
  • Author(s): 冨永光俊、高森建二
  • Organizer: 第47回日本小児アレルギー学会
  • Place of Presentation: 横浜
• [Presentation] ケラチノサイト由来anosmin-1はアトピー性皮膚炎における表皮内神経密度調節に関与する (2010)
  • Author(s): Suhandy Tengara、冨永光俊、加茂敦子、種田研一、根木治、高森建二
  • Organizer: 第109回日本皮膚科学会総会
  • Place of Presentation: 大阪
• [Presentation] ドライスキンモデルマウスにおける表皮内神経線維に対する紫外線療法の影響 (2010)
  • Author(s): 加茂敦子、冨永光俊、高森建二
  • Organizer: 第109回日本皮膚科学会総会
  • Place of Presentation: 大阪
• [Presentation] 乾癬の痒みのメカニズム-表皮内神経とオピオイドシステムの影響- (2010)
  • Author(s): 種田研一、冨永光俊、根木治、加茂敦子、Suhandy Tengara、加茂敦子、高森建二
  • Organizer: 第109回日本皮膚科学会総会
  • Place of Presentation: 大阪
• [Presentation] 皮膚の乾燥に由来する痒みのメカニズムと対策 (2010)
  • Author(s): 冨永光俊、高森建二
  • Organizer: 第6回加齢皮膚医学研究会
  • Place of Presentation: 新潟
• [Presentation] 乾癬におけるかゆみの解析 (2010)
  • Author(s): 種田研一、冨永光俊、根木治、Suhandy Tenagara、加茂敦子、須賀康、高森建二
  • Organizer: 第25回角化症研究会
  • Place of Presentation: 東京
• [Presentation] アトピー性皮膚炎における知覚神経線維の基底膜侵入メカニズム-マトリックスプロテアーゼ-2の関与- (2010)
  • Author(s): 冨永光俊、高森建二
  • Organizer: 第15回日本病態プロテアーゼ学会学術集会
  • Place of Presentation: 大阪
• [Presentation] 表皮内神経に対する光線療法、ステロイド軟膏、保湿剤の効果 (2010)
  • Author(s): 加茂敦子、冨永光俊、高森建二
  • Organizer: 第20回国際痒みシンポジウム
  • Place of Presentation: 東京
• [Presentation] ケラチノサイト由来anosmin-1はアトピー性皮膚炎における表皮内神経密度調節に関与する (2010)
  • Author(s): Suhandy Tengara、冨永光俊、加茂敦子、種田研一、根木治、高森建二
  • Organizer: 第20回国際痒みシンポジウム
  • Place of Presentation: 東京
• [Presentation] Histological characterization of cutaneous nerve fibers containing gastrin-releasing peptide in NC/Nga mice, an atopic dermatitis model. (2010)
  • Author(s): 冨永光俊, 高森建二
  • Organizer: 第35回日本研究皮膚科学会
  • Place of Presentation: 和歌山
• [Presentation] Thymic stromal lymphopoietin and tumor necrosis factor-reduces the production of semaphorin 3A in cultured human epidermal keratinocytes. (2010)
  • Author(s): Tengara S, Tominaga M, Kamo A, Negi O, Taneda K, Ogawa H, Takamori K
  • Organizer: 第35回日本研究皮膚科学会
  • Place of Presentation: 和歌山
• [Presentation] Anti-nerve growth effects of topical photo(chemo)therapy, corticosteroid ointment and emollient in acetone-treated mice, an dry skin model. (2010)
  • Author(s): Kamo A, Tominaga M, Ngi O, Tengara S, Taneda K, Ogawa H, Takamori K
  • Organizer: 第35回日本研究皮膚科学会
  • Place of Presentation: 和歌山
• [Presentation] Topically applied semaphorin 3A ointment inhibits scratching behavior and improves skin inflammation in NC/Nga mice with atopic dermatitis. (2010)
  • Author(s): Negi O, Tominaga M, Taneda K, Kamo A, Tengara S, Ogawa H, Takamori K
  • Organizer: 第35回日本研究皮膚科学会
  • Place of Presentation: 和歌山
• [Presentation] Neurotropin inhibits both capsaicin-induced substance P release and nerve growth factor-induced neurite outgrowth in cultured rat dorsal root ganglion neurons. (2010)
  • Author(s): Taneda K, Tominaga M, Tengara S, Ogawa H, Takamori K
  • Organizer: 第35回日本研究皮膚科学会
  • Place of Presentation: 和歌山
• [Presentation] アトピー性皮膚炎モデル・NC/Ngaマウスの皮膚における6-ニトロトリプトファン含有タンパク質の生成 (2010)
  • Author(s): 川崎広明、冨永光俊、重永綾子、加茂敦子、小川秀興、高森建二、山倉文幸
  • Organizer: 第32回トリプトファン研究会
  • Place of Presentation: 滋賀
• [Presentation] Recent advances in the pathophysiology of itch in atopic dermatitis. (2010)
  • Author(s): 高森建二, 冨永光俊
  • Organizer: 19^<th> EADV
  • Place of Presentation: Gothenburg
• [Presentation] Recent advances in the pathophysiology of itch in atopic dermatitis. (2010)
  • Author(s): Takamori K, Tominaga M
  • Organizer: 19^<th> European Academy of Dermatology and Venereology
  • Place of Presentation: Gothenburg
• [Presentation] Regulation of itch in atopic dermatitis-Involvement of Sema3A-. (2009)
  • Author(s): Takamori K, Tominaga M, Taneda K, Negi O
  • Organizer: 10^<th> International Congress of Dermatology
  • Place of Presentation: Czech
  • Year and Date: 2009-05-21
• [Presentation] Regulation of itch in atopic dermatitis-Involvement of Sema3A- (2009)
  • Author(s): Takamori K, Tominaga M
  • Organizer: 10^<th> International Congress of Dermatology
  • Place of Presentation: Czech
  • Year and Date: 2009-05-21
• [Presentation] オピオイドと痒み (2009)
  • Author(s): 冨永光俊
  • Organizer: 第108回日本皮膚科学会総会
  • Place of Presentation: 福岡
• [Presentation] アトピー性皮膚炎マウスにおけるガストリン放出ペプチド含有神経の組織学的特性化 (2009)
  • Author(s): 冨永光俊、高森建二
  • Organizer: 第19回国際痒みシンポジウム
  • Place of Presentation: 大阪
• [Presentation] In vitro model for penetration of sensory nerve fibers on a Matrigel basement membrane : Implications for possible application to intractable pruritus. (2009)
  • Author(s): 冨永光俊、高森建二
  • Organizer: 第34回日本研究皮膚科学会
  • Place of Presentation: 福岡
• [Presentation] 乾癬の痒みに関する研究-痒みを伴う乾癬皮疹における表皮内神経線維の関与- (2009)
  • Author(s): 種田研一、冨永光俊、根木治、加茂敦子、Suhandy Tengara、高森建二
  • Organizer: 第64回日本皮膚科学会山梨地方会
  • Place of Presentation: 山梨
• [Presentation] Implications for peripheral opioid systems to pruritus. (2009)
  • Author(s): 冨永光俊, 高森建二
  • Organizer: 5^<th> International Workshop for the Study of Itch
  • Place of Presentation: Tokyo, Japan
• [Presentation] Epidermal nerve density is modulated by keratinocyte-produced anosmin-1. (2009)
  • Author(s): Tengara S, Tominaga M, Takamori K
  • Organizer: 5^<th> International Workshop for the Study of Itch
  • Place of Presentation: Tokyo, Japan
• [Presentation] Evaluation of epidermal nerve density and opioid receptor levels in psoriatic itch. (2009)
  • Author(s): Taneda K, Tominaga M, Negi O, Kamo A, Tengara S, Ogawa H, Takamori K
  • Organizer: 5^<th> International Workshop for the Study of Itch
  • Place of Presentation: Tokyo, Japan
• [Presentation] 性感染症について (2008)
  • Author(s): 高森建二
  • Organizer: 第41回東総産婦人科医会講演会
  • Place of Presentation: 旭市
  • Year and Date: 2008-12-11
• [Presentation] 透析患者の痒みのメカニズムとその対策について (2008)
  • Author(s): 高森建二
  • Organizer: 香川県臨床工学技士会サテライトセミナー
  • Place of Presentation: 高松市
  • Year and Date: 2008-12-07
• [Presentation] 難治性痒みを制御する-特に透析患者の痒みのメカニズムとその対策について- (2008)
  • Author(s): 高森建二
  • Organizer: 第53回神戸皮膚科臨床研究会
  • Year and Date: 2008-12-06
• [Presentation] 難治性痒みを制御する-アトピー性皮膚炎と透析に伴う痒みのメカニズムとその対策について- (2008)
  • Author(s): 高森建二
  • Organizer: 城南区医師会学術講演会
  • Year and Date: 2008-11-12
• [Presentation] 乾燥肌を呈する疾患の痒み-老人性乾皮症と透析に伴う痒みについて- (2008)
  • Author(s): 高森建二
  • Organizer: 北多摩皮膚科医会学術講演会
  • Place of Presentation: 武蔵野市
  • Year and Date: 2008-10-15
• [Presentation] 難治性痒みを制御する-特に透析を伴う痒みとアトピー性皮膚炎の痒みについて- (2008)
  • Author(s): 高森建二
  • Organizer: 札幌市医師会五支部合同学術講演会
  • Place of Presentation: 札幌市
  • Year and Date: 2008-08-26
• [Presentation] 難治性そう痒症の新たな展開 (2008)
  • Author(s): 高森建二
  • Organizer: 第53回日本透析医学会学術集会
  • Place of Presentation: 神戸市
  • Year and Date: 2008-06-22
• [Presentation] 医療訴訟を防ぐために (2008)
  • Author(s): 高森建二
  • Organizer: 第71回日本皮膚科学会第817回東京地方会
  • Place of Presentation: 東京
  • Year and Date: 2008-06-19
• [Presentation] 難治性痒みを制御する-特に透析を伴う痒みとアトピー性皮膚炎の痒みについて- (2008)
  • Author(s): 高森建二
  • Organizer: 第50回愛知県皮膚科医会総会
  • Place of Presentation: 名古屋市
  • Year and Date: 2008-05-10
• [Presentation] 難治性痒みを制御する-特に透析を伴う痒みとアトピー性皮膚炎の岸みについて- (2008)
  • Author(s): 高森建二
  • Organizer: 第50回愛知県皮膚科医会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-05-10
• [Presentation] 難治性痒みを制御する-特に透析を伴う痒みとアトピー性皮膚炎の痒みについて- (2008)
  • Author(s): 高森建二
  • Organizer: タリオンOD錠発売記念講演会,宮崎県皮膚科医会
  • Place of Presentation: 仙台市
  • Year and Date: 2008-04-03
• [Presentation] 皮膚疾患の診断学の向上と治療学の確立 (2008)
  • Author(s): 高森建二
  • Organizer: 第10回岐阜臨床皮膚科懇話会
  • Place of Presentation: 岐阜市
  • Year and Date: 2008-01-17
• [Presentation] 乾癬の痒みに関する研究-痒みを伴う乾癬皮疹における表皮内神経線維の関与- (2008)
  • Author(s): 種田研一、冨永光俊、根木治、須賀康、高森建二
  • Organizer: 第23回日本乾癬学会学術大会
  • Place of Presentation: 旭川市
• [Presentation] エタネルセプトが奏功した難治性壊疽性膿皮症の2例 (2008)
  • Author(s): 木村有太子,松葉祥一,水野優起,千見寺貴子,木下綾子,金子礼志,関川巌,高森建二,須賀康
  • Organizer: 第72回日本皮膚科学会東部支部学術大会
  • Place of Presentation: 秋田市
• [Presentation] アトピー性皮膚炎患者に対するロラタジン治療下におけるTARC、CTACKの治療マーカーとしての有用性の検討 (2008)
  • Author(s): 木村有太子, 松葉祥一,千見寺貴子,春名邦隆,須賀康,高森建二
  • Organizer: 第58回日本アレルギー学会秋季学術大会
  • Place of Presentation: 東京
• [Presentation] 表皮内でのSema3Aの発現の低下と、表皮内神経伸長を認めたアミロイド苔癬 (2008)
  • Author(s): 種田研一、冨永光俊、根木治、須賀康、高森建二
  • Organizer: 第72回日本皮膚科学会東部支部学術大会
  • Place of Presentation: 秋田市
• [Presentation] Mechanism of itch in atopic dermatitis-Involvement of opioid systems-. (2008)
  • Author(s): 冨永光俊, 高森建二
  • Organizer: 5^<th> Georg Rajka International Symposium on Atopic Dermatitis (5th ISAD)
  • Place of Presentation: Kyoto, Japan
• [Presentation] Involvement of keratinocyte-derived semaphorin 3A in epidermal innervation of atopic dermatitis. (2008)
  • Author(s): 冨永光俊, 高森建二
  • Organizer: 5^<th> International Investigative Dermatology (IID)
  • Place of Presentation: Kyoto, Japan
• [Presentation] (2008)
  • Author(s): 高森建二
  • Organizer: ポーランド皮膚科学会及びポーランド科学アカデミー実験免疫学研究所での招待講演
  • Place of Presentation: ポーランド(ヴロツワフ)
• [Book] Skin Biopsy. Intech. (2011)
  • Author(s): 冨永光俊, 高森建二
  • Publisher: (in press)
• [Book] からだと光の事典(光と神経) (2010)
  • Author(s): 冨永光俊、高森建二
  • Publisher: 朝倉書店
• [Book] からだと光の事典, 光と神経 (2010)
  • Author(s): 冨永光俊、高森建二
  • Total Pages: 2
  • Publisher: 朝倉書店
• [Book] kappa-オピオイド受容体アゴニストによる難治性掻痒の治療. (2008)
  • Author(s): 高森建二
  • Publisher: 医薬ジャーナル社
• [Remarks] ホームページ等
• [Remarks] 冨永光俊、高森建二.アトピー性皮膚炎におけるかゆみの機序.Monthly Book Derma. 2011, in press.
• [Remarks] 熊谷裕生、丸山資郎、中元秀友、江畑俊哉、高森建二、鈴木洋通.既存治療に抵抗性のかゆみに対する、κ受容体作動薬ナルフラフィンの効果.アレルギー免疫.17巻9号,1520-1529,2010
• [Remarks] 高森建二、根木治.患者さんのための腎臓病学入門講座透析患者さんのかゆみそのメカニズムと対処法について.腎不全を生きる,41巻,25-28,2010
• [Remarks] 冨永光俊、高森建二.痒みにおける表皮内神経の制御機構.アレルギー・免疫.Vol.17,No.9,38-44,2010
• [Remarks] 種田研一、根木治、冨永光俊、高森建二.難治性かゆみの発現機序.綜合臨床.Vol.59,No.8,1842-1844,2010
• [Remarks] 冨永光俊.光線療法による表皮内神経の制御-アトピー性皮膚炎の痒みについて-.日本皮膚科学会雑誌.120(13),2010
• [Remarks] 冨永光俊、高森建二.痒みとオピオイド、カンナビノイド.アレルギー・免疫.Vol.17,No.11,66-72,201011月号
• [Remarks] 種田研一、根木治、冨永光俊、高森建二.乾癬の痒みとオピオイドシステム.皮膚病診療.Vol.32,No.11,1154-1159,2010
• [Remarks] 冨永光俊.オピオイドと痒み.日本皮膚科学会雑誌.119(13),2502-2505,2009
• [Remarks] 冨永光俊、種田研一、高森建二.表皮内神経と痒み.アレルギーの臨床.Vol.29, No.10,27-32,2009
• [Remarks] 高森建二.痒み難治性痒みの発現メカニズム乾燥、透析、アトピー性皮膚炎について.日本皮膚科学会雑誌,118巻10号,1931-1939,2008
• [Remarks] 高森建二,熊谷裕生,江畑俊哉,鈴木洋通.kappa-オピオイド受容体アゴニストによる難治性掻痒の治療.アレルギー免疫,医薬ジャーナル社3,74-79,2008
• [Remarks] 高森建二,種田研一,冨永光俊.アトピー性皮膚炎のバリア機能異常と痒みの関係.アレルギーの臨床.28,28-33,2008
• [Remarks] 江畑俊哉,熊谷裕生,高森建二.透析患者の痒みにオピオイド系薬剤は有効か?.EBM皮膚疾患の治療,中外医学社2008-2009,76-81,2008
• [Remarks] 高森建二.名医が解説する症状から分かる病気の本,角川SSコミュニケーションズ152-155,2008
• [Remarks] 高森建二.最近の話題.Clinical Derma, 1-2,2008
• [Remarks] 松葉祥一,高森建二.薬剤性脱毛症とその治療.Derma. No.145,50-54,2008
• [Remarks] 高森建二.かゆみへの包括的アプローチと抗ヒスタミン薬の役割.PROGRESS IN MEDICINE, Vol 27,No,8,9-12,2008
• [Remarks] 高森建二.痒みを科学する-特に内因性オピオイドmu/kappa系システムを中心に-.感染・炎症・免疫,Vol 138,4,82-86,2008
• [Remarks] 高森建二.冬季に注意を要する高齢者の皮膚疾患.治験治療,No.692,34-39,2008
• [Remarks] 佐藤英里,松葉祥一,高森建二.汎発性脱毛症患者に生じた皮様嚢腫の1例.皮膚の臨床,50巻3号,430-431,2008
• [Remarks] 高森建二.肌の乾燥を防ぐ.クック&ライフ1月号,8-9,2008
• [Remarks] 高森建二.寒冷じんましん(インタビュー記事).月刊みすみ第497号,2008
• [Remarks] 高森建二.入浴後こまめに保湿剤を高齢者に多い皮膚のかゆみ(インタビュー記事).十勝新聞,Feb 4,2008
• [Remarks] 高森建二.乾燥性の皮膚トラブル(インタビュー記事).月刊みすみ第504号,2008
• [Remarks] 高森建二.抗ヒスタミン薬抵抗性の難治性痒みにオピオイド系が関与.Medical Tribune Vol 41-42,Oct 9,2008
• [Remarks] 高森建二.肌のかゆみ(インタビュー記事).読売新聞,Nov 22,2008
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• [Remarks]
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