Behavioral and biochemical change in animal model of depression.

Research Project

Project/Area Number	20591367
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Psychiatric science
Research Institution	Okayama University
Principal Investigator	KODAMA Masafumi Okayama University, 大学院・医歯薬学総合研究科, 助教 (80379726)
Project Period (FY)	2008 – 2010
Project Status	Completed (Fiscal Year 2010)
Budget Amount *help	¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000) Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords	精神薬理学 / うつ病 / 神経新生 / 神経栄養因子 / 強制水泳試験 / 電気けいれん
Research Abstract	Signal cascades activated by neurotrophic factors such as brain-derived nerotrophic factor were examined by using animal models of depression. MAPK/ERK cascade was appeared to play a key role in the mechanisms of antidepressant action. Inhibition of this cascade resulted in block of both of antidepressive behavioral change and of increase of neurogenesis in hippocampus. These results suggest that activation of MAPK/ERK may exert antidepressive effects in depressive patients.

Report

(4 results)