| Project/Area Number |
20591379
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | St.Marianna University School of Medicine |
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Principal Investigator |
MIYAMOTO Seiya St.Marianna University School of Medicine, 医学部, 准教授 (00288200)
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| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 統合失調症 / 第2世代抗精神病薬 / 抗コリン薬 / 認知機能障害 / Quality of life / Quality of Life / 離脱症状 / 錐体外路症状 / 学習効果 / aripiprazole / blonanserin / risperidone |
|---|
| Research Abstract |
The aim of this study was to evaluate the effects of gradual discontinuation of concomitant biperiden, an anticholinergic drug, on cognitive function and quality of life (QOL) in patients with schizophrenia who had received a second-generation antipsychotic drug. Biperiden was discontinued safely in most patients, and significant improvements were shown in attention, processing speed, general cognitive function, and QOL. We believe that this study provides evidence for a safe strategy for discontinuation of an anticholinergic drug and its clinical significance in schizophrenia.
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