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Research on the effects of discontinuation of long-term anticholinergic drug use in patients with schizophrenia

Research Project

Project/Area Number 20591379
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionSt.Marianna University School of Medicine

Principal Investigator

MIYAMOTO Seiya  St.Marianna University School of Medicine, 医学部, 准教授 (00288200)

Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords統合失調症 / 第2世代抗精神病薬 / 抗コリン薬 / 認知機能障害 / Quality of life / Quality of Life / 離脱症状 / 錐体外路症状 / 学習効果 / aripiprazole / blonanserin / risperidone
Research Abstract

The aim of this study was to evaluate the effects of gradual discontinuation of concomitant biperiden, an anticholinergic drug, on cognitive function and quality of life (QOL) in patients with schizophrenia who had received a second-generation antipsychotic drug. Biperiden was discontinued safely in most patients, and significant improvements were shown in attention, processing speed, general cognitive function, and QOL. We believe that this study provides evidence for a safe strategy for discontinuation of an anticholinergic drug and its clinical significance in schizophrenia.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (19 results)

All 2011 2010 2009 2008

All Journal Article (6 results) (of which Peer Reviewed: 2 results) Presentation (11 results) Book (2 results)

  • [Journal Article] Effects of discontinuation of long-term biperiden use on cognitive function and quality of life in schizophrenia2011

    • Author(s)
      Shin Ogino、Seiya Miyamoto、他
    • Journal Title

      Progress in Neuro-Psychopharmacology & Biological Psychiatry 35巻

      Pages: 78-83

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of discontinuation of long-term biperiden use on cognitive function and quality of life in schizophrenia2011

    • Author(s)
      Shin Ogino, 他15名
    • Journal Title

      Progress in Neuro-Psychopharmacology & Biological Psychiatry

      Volume: 35 Pages: 78-83

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 統合失調症の認知増強薬:最近の話題2009

    • Author(s)
      天神朋美、北島麗、荻野信、宮本聖也
    • Journal Title

      精神科 14巻

      Pages: 525-529

    • Related Report
      2010 Final Research Report
  • [Journal Article] 統合失調症の認知増強薬:最近の話題2009

    • Author(s)
      天神朋美, 他3名
    • Journal Title

      精神科 14

      Pages: 525-529

    • Related Report
      2009 Annual Research Report
  • [Journal Article] ブロナンセリンの長期投与2008

    • Author(s)
      宮本聖也、他
    • Journal Title

      精神科 13巻

      Pages: 472-477

    • Related Report
      2010 Final Research Report
  • [Journal Article] ブロナンセリンの長期投与2008

    • Author(s)
      宮本聖也, 他4名
    • Journal Title

      精神科 13

      Pages: 472-477

    • Related Report
      2008 Annual Research Report
  • [Presentation] 第2世代抗精神病薬に長期併用投与されたbiperidenの減量・中止が統合失調症患者の認知機能とQuality of Lifeに及ぼす効果2010

    • Author(s)
      荻野信、宮本聖也、他
    • Organizer
      第20回日本臨床精神神経薬理学会
    • Place of Presentation
      仙台国際センター(宮城県)
    • Year and Date
      2010-09-16
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] Effects of gradual discontinuation of concomitant anticholinergics administered long-term with second-generation antipsychotics on cognitive function and quality of life in schizophrenia2010

    • Author(s)
      荻野信、宮本聖也、他
    • Organizer
      XXVII CINP Congress
    • Place of Presentation
      Hong Kong Convention and Exhibition Centre (Hong Kong)
    • Year and Date
      2010-06-07
    • Related Report
      2010 Final Research Report
  • [Presentation] Effects of gradual discontinuation of concomitant anticholinergics administered long-term with second-generation antipsychotics on cognitive function and quality of Life in schizophrenia2010

    • Author(s)
      Shin Ogino, 他7名
    • Organizer
      XXVII CINP Congress
    • Place of Presentation
      Hong Kong Convention and Exhibition Centre (Hong Kong)
    • Year and Date
      2010-06-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] 第2世代抗精神病薬に長期併用投与された抗コリン薬の減量中止が統合失調症患者の認知機能および主観的Quality of Lifeに及ぼす影響2010

    • Author(s)
      荻野信、宮本聖也、他
    • Organizer
      第5回日本統合失調症学会
    • Place of Presentation
      九州大学医学部百年講堂(福岡県)
    • Year and Date
      2010-03-27
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] 第2世代抗精神病薬に長期併用投与された抗コリン薬の減量中止が統合失調症患者の認知機能およびQuality of Lifeに及ぼす影響2009

    • Author(s)
      荻野信、宮本聖也、他
    • Organizer
      第19回日本臨床精神神経薬理学会
    • Place of Presentation
      国立京都国際会館(京都府)
    • Year and Date
      2009-11-14
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] 第2世代抗精神病薬投与中の統合失調症患者に長期併用された抗コリン薬の減量中止が認知機能およびQuality of Lifeに及ぼす影響2009

    • Author(s)
      荻野信、宮本聖也、他
    • Organizer
      第4回日本統合失調症学会
    • Place of Presentation
      大阪大学コンベンションセンター(大阪府)
    • Year and Date
      2009-01-30
    • Related Report
      2010 Final Research Report
  • [Presentation] 第2世代抗精神病薬投与中の統合失調症患者に長期併用された抗コリン薬の減量中止が認知機能およびQuality of Lifeに及ぼす影響2009

    • Author(s)
      荻野 信, 他12名
    • Organizer
      第4回日本統合失調症学会
    • Place of Presentation
      大 阪
    • Year and Date
      2009-01-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] 第2世代抗精神病薬に長期併用投与された抗コリン薬の減量中止が統合失調症患者のQuality of Lifeに及ぼす影響2008

    • Author(s)
      釘宮麗、宮本聖也、他
    • Organizer
      第18回日本臨床精神神経薬理学会
    • Place of Presentation
      品川プリンスホテル(東京都)
    • Year and Date
      2008-10-03
    • Related Report
      2010 Final Research Report
  • [Presentation] 第2世代抗精神病薬に長期併用投与された抗コリン薬の減量中止が統合失調症患者の認知機能に及ぼす影響2008

    • Author(s)
      荻野信、宮本聖也、他
    • Organizer
      第18回日本臨床精神神経薬理学会
    • Place of Presentation
      品川プリンスホテル(東京都)
    • Year and Date
      2008-10-03
    • Related Report
      2010 Final Research Report
  • [Presentation] 第2世代抗精神病薬に長期併用投与された抗コリン薬の減量中止が統合失調症患者の認知機能に及ぼす影響2008

    • Author(s)
      荻野 信, 他14名
    • Organizer
      第18回日本臨床精神神経薬理学会
    • Place of Presentation
      東 京
    • Year and Date
      2008-10-03
    • Related Report
      2008 Annual Research Report
  • [Presentation] 第2世代抗精神病薬に長期併用投与された抗コリン薬の減量中止が統合失調症患者のQuality of Lifeに及ぼす影響2008

    • Author(s)
      釘宮 麗, 他12名
    • Organizer
      第18回日本臨床精神神経薬理学会
    • Place of Presentation
      東 京
    • Year and Date
      2008-10-03
    • Related Report
      2008 Annual Research Report
  • [Book] 抗精神病薬完全マスター2011

    • Author(s)
      天神朋美、宮本聖也
    • Publisher
      医学書院(印刷中)
    • Related Report
      2010 Final Research Report
  • [Book] 抗精神病薬完全マスター2011

    • Author(s)
      天神朋美, 他1名
    • Publisher
      医学書院(印刷中)
    • Related Report
      2010 Annual Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

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