| Project/Area Number |
20591424
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Kawasaki Medical School |
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Principal Investigator |
NAKAGAWA Akiko Kawasaki Medical School, 医学部, 准教授 (70253424)
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIURA Takashi 九州大学, 大学病院, 講師 (40322747)
NAKAO Tomohiro 九州大学, 医学研究院, 助教 (50423554)
SANEMATSU Hirokuni 九州大学, 大学病院, 助教 (30588116)
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| Co-Investigator(Renkei-kenkyūsha) |
KANBA Shigenobu 九州大学, 医学系研究科, 教授 (50195187)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 強迫性障害 / 機能的MRI / 脳機能 / 治療効果 / SSRI / 行動療法 / Stroop test / fMRI / Stroop Test |
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| Research Abstract |
We investigated the differences of brain change among OCD patients treated with BT, fluvoxamine (FLV), and control treatment using Stroop test assessing inhibition processes that might be related with OCD symptoms. As the result, only the right dorsolateral prefrontal cortex (DLPFC) was detected in analysis comparing the FLV group to the control group. The region( not right, but left), as well as other several ones in temporal and parietal area, showed significantly different change in analysis between the BT group and the control group, too. The DLPFC has been suggested as one of the regions related to the pathophysiology of OCD, especially in planning aspects of executive function.
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