CHANGE OF BRAIN FUNCTION ALONG WITH TREATMENT EFFECT IN PATIENTS WITH OBSESSIVE-COMPULSIVE DISORDRDER ; AN FUNCTIONAL MRI STUDY

• Project/Area Number: 20591424
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Kawasaki Medical School
• Principal Investigator: NAKAGAWA Akiko Kawasaki Medical School, 医学部, 准教授 (70253424)
• Co-Investigator(Kenkyū-buntansha): YOSHIURA Takashi 九州大学, 大学病院, 講師 (40322747) ; NAKAO Tomohiro 九州大学, 医学研究院, 助教 (50423554) ; SANEMATSU Hirokuni 九州大学, 大学病院, 助教 (30588116)
• Co-Investigator(Renkei-kenkyūsha): KANBA Shigenobu 九州大学, 医学系研究科, 教授 (50195187)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 強迫性障害 / 機能的MRI / 脳機能 / 治療効果 / SSRI / 行動療法 / Stroop test / fMRI / Stroop Test

Research Abstract

We investigated the differences of brain change among OCD patients treated with BT, fluvoxamine (FLV), and control treatment using Stroop test assessing inhibition processes that might be related with OCD symptoms. As the result, only the right dorsolateral prefrontal cortex (DLPFC) was detected in analysis comparing the FLV group to the control group. The region( not right, but left), as well as other several ones in temporal and parietal area, showed significantly different change in analysis between the BT group and the control group, too. The DLPFC has been suggested as one of the regions related to the pathophysiology of OCD, especially in planning aspects of executive function.

Research Products

• [Journal Article] Current status of research on cognitive therapy/cognitive behavior therapy in Japan (2011)
  • Author(s): Yutaka Ono
  • Journal Title: Psychiatry and Clinical Neuroscience Volume: 65 Pages: 121-129
  • Peer Reviewed
• [Journal Article] Predictors of treatment response to fluvoxamine in obsessive-compulsive disorder : An fMRI study. (2010)
  • Author(s): Sanematsu H., Nakao T., Yoshiura T., Nabeyama M., Togao O., Tomita M., Masuda Y., Yoshioka K., Nakatani E., Nakagawa A., Kanba S.
  • Journal Title: J.Psychiatr.Res. 44 Pages: 193-200
  • NAID: 120005289467
  • Peer Reviewed
• [Journal Article] Regional gray and white matter volume abnormalities in obsessive-compulsive disorder : A voxel-based morphometry study. (2010)
  • Author(s): Togao O., Yoshiura T., Nakao T., Nabeyama M., Sanematsu H., Nakagawa A., Noguchi T., Hiwatashi A., Yamashita K., Nagao E., Kanba S.
  • Journal Title: Psychiatry.Res. 184 Pages: 29-37
  • Peer Reviewed
• [Journal Article] Regional gray and white matter volume abnormalities in obsessive-compulsive disorder : a voxel-based morphometry study (2010)
  • Author(s): Togao O
  • Journal Title: Psychiatry Res Neuroimaging Volume: 184(1) Pages: 29-37
  • Peer Reviewed
• [Journal Article] 行動療法における初期面接-強迫性障害を中心に (2010)
  • Author(s): 中川彰子
  • Journal Title: 精神療法 Volume: 36(4) Pages: 466-471
• [Journal Article] Predictors of treatment response to fluvoxamine in obsessive-compulsive disiorder : An fMRI study (2010)
  • Author(s): Sanematsu H
  • Journal Title: J Psychiatr Res 44(4) Pages: 193-200
  • Peer Reviewed
• [Journal Article] Duration effect of obsessive-compulsive disorder on cognitive function : a functional MRI study (2009)
  • Author(s): Nakao T., Nakagawa A., Yoshiura T., Nakatani E., Nabeyama M., Sanematsu H., Togao O., Yoshioka K., Tomita M., Kuroki T., Kanba S.
  • Journal Title: Depress Anxiety 26 Pages: 814-823
  • Peer Reviewed
• [Journal Article] Working memory dysfunction in obsessive-compulsive disorder : a neuropsychological and functional MRI study. (2009)
  • Author(s): Nakao T., Nakagawa A., Nakatani E., Nabeyama M., Sanematsu H., Yoshiura T., Togao O., Tomita M., Masuda Y., Yoshioka K., Kuroki T., Kanba S.
  • Journal Title: J.Psychiatr.Res. 43 Pages: 784-791
  • Peer Reviewed
• [Journal Article] 広汎性発達障害と強迫性障害 (2009)
  • Author(s): 中川彰子
  • Journal Title: 精神療法 35(5) Pages: 392-395
• [Journal Article] functional MRI study of brain-activation alterations in patients with obsessive-compulsive disorder after symptom improvement (2009)
  • Author(s): Nabeyama M., Nakagawa A., Yoshiura T., Nakao T., Nakatani E., Togao O.,Yoshizato C., Yoshioka K., Tomita M., Kanba S.
  • Journal Title: Psychiatry res Neuroimaging 163 Pages: 236-247
  • Peer Reviewed
• [Journal Article] Duration effect of obsessive-compulsive disorder on cognitive function (2009)
  • Author(s): Nakao T
  • Journal Title: Depress Anxiety 26 Pages: 814-823
  • Peer Reviewed
• [Journal Article] 強迫性障害の行動療法効果と脳機能画像変化 (2009)
  • Author(s): 鍋山麻衣子
  • Journal Title: 精神療法 35(6) Pages: 738-743
• [Journal Article] (2009)
  • Author(s): 中川彰子
  • Journal Title: 専門医のための精神科臨床ニュミエール11(青木省三/中川彰子編)(中山書店) Pages: 194-206
• [Journal Article] Outcome of additional behaviour therapy including treatment discontinuation for fluvoxamine non-responders with obsessive-compulsive disorder.Psychother. (2008)
  • Author(s): Nakatani E., Nakagawa A.
  • Journal Title: Psychosom 77 Pages: 393-394
  • Peer Reviewed
• [Journal Article] fMRIでみる強迫性障害の脳機能 (2008)
  • Author(s): 鍋山麻衣子,中川彰子
  • Journal Title: 臨床精神医学 37 Pages: 779-785
• [Journal Article] Working memory dysfunction in obsessive-compulsive disorder : a neuropsychological and functional MRI study (2008)
  • Author(s): Tomohiro Nakao
  • Journal Title: J Psychiat Res 43(8) Pages: 784-791
  • Peer Reviewed
• [Journal Article] Functional MRI study of brain activation alterations in patients with obsessive-compulsive disorder after symptom improvement (2008)
  • Author(s): Maiko Nabeyama
  • Journal Title: Psychiat Res 163(3) Pages: 236-47
  • Peer Reviewed
• [Journal Article] fMRIでみる強迫性障害の脳機能 (2008)
  • Author(s): 鍋山麻衣子, 中川彰子
  • Journal Title: 臨床精神医学 37(6) Pages: 779-785
• [Presentation] Symptom Structure in Japanese Patients with Obsessive-Compulsive Disorder (2010)
  • Author(s): Akiko Nakagawa
  • Organizer: 第40回ヨーロッパ行動療法認知療法会議
  • Place of Presentation: ミラノ、イタリア
  • Year and Date: 2010-10-08
• [Presentation] The effect of behaviour therapy on brain function in patients with Obsessive Compulsive Disorder-A comparison study using fMRI- (2010)
  • Author(s): Kayoko Isomura
  • Organizer: 第40回ヨーロッパ行動療法認知療法会議
  • Place of Presentation: ミラノ、イタリア
  • Year and Date: 2010-10-08
• [Presentation] Differential brain activation in obsessive-compulsive disorder patients with washing compared with checking symptom during symptom provocation (2010)
  • Author(s): Keitaro Murayama
  • Organizer: 第40回ヨーロッパ行動療法認知療法会議
  • Place of Presentation: ミラノ、イタリア
  • Year and Date: 2010-10-08
• [Presentation] Symptom Structure in Japanese Patients with Obsessive-Compulsive Disorder. (2010)
  • Author(s): Nakagawa A., Yoshioka K., Nakao T., Yamashita Y., Sanematsu H.
  • Organizer: 40th EABCT
  • Place of Presentation: Milan, Italy.
• [Presentation] The effect of behaviour therapy on brain function in patients with Obsessive Compulsive Disorder (2010)
  • Author(s): Isomura K., Nakao T., Sanematsu H., Yoshiura T., Yoshioka K., Tomita M., Masuda Y., Nakagawa A
  • Organizer: A comparison study using fMRI-40th EABCT
  • Place of Presentation: Milan, Italy.
• [Presentation] The effect of behaviour therapy on brain function in patients with obsessive-compulsive disorder-A comparison study using fMRI (2009)
  • Author(s): Kayoko Isomura
  • Organizer: 39^<th> EABCT Annual Congress
  • Place of Presentation: Dubrovnik, Croatia
  • Year and Date: 2009-09-17
• [Presentation] Working memory dysfunction in obsessive-compulsive disorder : A neuropsychological and functional MRI study (2009)
  • Author(s): Nakao T., Nakagawa A., Nabeyama M., Sanematsu H., Yoshiura T., Tomita M., Masuda Y., Kanba S.
  • Organizer: 9^<th> World Congress of Biological Psychiatry
  • Place of Presentation: Paris, France.
• [Presentation] Treatment effect of behaviour therapy in obsessive-compulsive disorder.A one year follow-up study. (2009)
  • Author(s): Nakagawa A., Nakao T., Nakatani E., Tomita M., Yoshioka K.
  • Organizer: 39^<th> EABCT
  • Place of Presentation: Dubrovnik, Croatia.
• [Presentation] The effect of behaviour therapy on brain function in patients with Obsessive Compulsive Disorder-A comparison study using fMRI. (2009)
  • Author(s): Isomura K., Nakao T., Sanematsu H., Masuda Y., Nakagawa A.
  • Organizer: 39^<th> EABCT
  • Place of Presentation: Dubrovnik, Croatia.
• [Presentation] Predictors of Response to Behaviour Therapy and Fluvoxamine in Obsessive Compulsive Disorder-A firm sumptom provocation Study-. (2008)
  • Author(s): Nakagawa A., Isomura K., Nakatani E., Nabeyama M., Nakao T., Sanematsu H., Yoshiura T.
  • Organizer: The 36^<th> BABCP
  • Place of Presentation: Edinburgh, United Kingdom.
• [Presentation] Stability of Personality Traits Over Time in OCD (Obsessive Compulsive Disorder). (2008)
  • Author(s): Nakagawa A., Isomura K., Nakatani E., Nakao T., Yoshioka K., Tomita M., Masuda Y.
  • Organizer: 38^<th> EABCT
  • Place of Presentation: Helsinki, Finland.
• [Presentation] Predictors of Response to Behaviour Therapy and Fluvoxamine in Obsessive Compulsive Disorder-A fMRI Symptom Provocation Study- (2008)
  • Author(s): Akiko Nakagawa
  • Organizer: 第36回イギリス行動療法認知療法学会
  • Place of Presentation: エジンバラ(イギリス)
• [Book] エキスパートによる強迫性障害(OCD)治療ブック (2010)
  • Author(s): 中川彰子
  • Total Pages: 232
  • Publisher: 星和書店
• [Book] 強迫性障害の研究(9)OCDの病態生理と治療反応性の関連 (2008)
  • Author(s): 中尾智博
  • Total Pages: 160
  • Publisher: 星和書店