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Development of algorithm for quantification of regional myocardial blood flow in patients with ischemic heart disease using 82Rb PET

Research Project

Project/Area Number 20591431
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionHokkaido University

Principal Investigator

KATOH Chietsugu  Hokkaido University, 大学院・保健科学研究院, 准教授 (10292012)

Co-Investigator(Kenkyū-buntansha) YOSHINAGA Keiichirou  北海道大学, 大学院・医学研究科, 准教授 (30435961)
志賀 哲  北海道大学, 大学院・医学研究科, 講師 (80374495)
Co-Investigator(Renkei-kenkyūsha) SHIGA Tohru  北海道大学, 大学院・医学研究科, 講師 (80374495)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2010: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2009: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2008: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Keywords虚血性心疾患 / PET / ルビジウム82 / 心筋血流 / 定量測定 / ルビジウム / コンパートメントモデル解析 / 再現性
Research Abstract

Three-dimensional (3D) PET with 82Rb yields myocardial image data with much spillover fraction from the blood. To calculate the regional myocardial blood flow (MBF) with 82Rb myocardial 3D PET, we developed a new algorithm to suppress the spillover using a non-uniform least squared fitting with a weighted function using a blood time-activity curve.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (26 results)

All 2010 2009 2008 Other

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (20 results) Remarks (1 results)

  • [Journal Article] Quantitative analysis of coronary endothelial function with generatorproduced ^<82>Rb PET : comparison with ^<15>O-labelled water PET.2010

    • Author(s)
      Yoshinaga K, Manabe O, Katoh C, Chen L, Klein R, Naya M, Dekemp RA, Williams K, Beanlands RS, Tamaki N.
    • Journal Title

      Eur J Nucl Med Mol Imaging 37(12)

      Pages: 2233-2241

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Quantitative analysis of coronary endothelial function with generator-produced 82Rb PET : comparison with 15O-labelled water2010

    • Author(s)
      Yoshinaga K
    • Journal Title

      Eur J Nucl Med Mol Imaging

      Volume: 37(12) Pages: 2233-2241

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Generator-produced rubidium-82 positron emission tomography myocardial perfusion imaging-From basic aspects to clinical applications2010

    • Author(s)
      Keiichiro Yoshinaga
    • Journal Title

      Journal of Cardiology 55

      Pages: 163-173

    • NAID

      10027051895

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Repeatability of rest and hyperemic myocardial blood flow measurements with 82Rb dynamic PET.2009

    • Author(s)
      Manabe O, Yoshinaga K, Katoh C, Naya M, deKemp RA, Tamaki N
    • Journal Title

      J Nucl Med 50(1)

      Pages: 68-71

    • NAID

      120003118182

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Repeatability of rest and hyperemic myocardial blood flow measurements with 82Rb dynamic PET2009

    • Author(s)
      Manabe O
    • Journal Title

      J Nucl. Med 50(1)

      Pages: 68-71

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 3D収集82Rb心筋PETにおける心筋血流定量の安定化:荷重関数を利用した血液成分補正法2010

    • Author(s)
      加藤千恵次
    • Organizer
      第50回日本核医学会学術総会
    • Place of Presentation
      大宮,大宮ソニックセンター
    • Year and Date
      2010-11-10
    • Related Report
      2010 Final Research Report
  • [Presentation] 3D収集^<82>Rb心筋PETにおける心筋血流定量の安定化:荷重関数を利用した血液成分補正法2010

    • Author(s)
      加藤千恵次
    • Organizer
      第50回日本核医学会学術総会g
    • Place of Presentation
      大宮ソニックシティ(埼玉県)
    • Year and Date
      2010-11-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] A new algorithm to suppress spillover fraction from the blood radioactivity for 82Rb myocardial 3D PET : Non-uniform least squared method with a weighted function using blood time-activity curve2010

    • Author(s)
      Katoh C
    • Organizer
      Seminar of Nuclear Medicine 57th.Annual Meeting
    • Place of Presentation
      Salt Palace Convention Center(Utah, USA)
    • Year and Date
      2010-06-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] A new algorithm to suppress spillover fraction from the blood radioactivity for 82Rb myocardial 3D PET : Non-uniform least squared method with a weighted function using blood time-activity curve2010

    • Author(s)
      Katoh, C.
    • Organizer
      The 57^<th> Annual Meeting of the Society of Nuclear Medicine
    • Place of Presentation
      Salt Lake City, USA, Salt Palace Convention Center(発表確定)
    • Year and Date
      2010-06-08
    • Related Report
      2009 Annual Research Report
  • [Presentation] Additional diagnostic value of regional myocardial blood flow quantification over relative perfusion imaging with Rubidium-82 PET2010

    • Author(s)
      Yoshinaga, K.
    • Organizer
      The 57^<th> Annual Meeting of the Society of Nuclear Medicine
    • Place of Presentation
      Salt Lake City, USA, Salt Palace Convention Center(発表確定)
    • Year and Date
      2010-06-08
    • Related Report
      2009 Annual Research Report
  • [Presentation] A new algorithm to suppress spillover fraction from the blood radioactivity for 82Rb myocardial 3D PET : Non-uniform least squared method with a weighted function using blood time-activity curve.2010

    • Author(s)
      Katoh C, Yoshinaga K, Manabe O, Tamaki N
    • Organizer
      57th Seminar of Nuclear Medicine
    • Place of Presentation
      Salt Lake City,Salt Lake City Convevtion Center, USA
    • Year and Date
      2010-06-07
    • Related Report
      2010 Final Research Report
  • [Presentation] Quantification of myocardial blood flow with Rubidium-82 3D-data acquisition-Comparison with O-15 labeled water dynamic PET2010

    • Author(s)
      Manabe, O.
    • Organizer
      The 57^<th> Annual Meeting of the Society of Nuclear Medicine
    • Place of Presentation
      Salt Lake City, USA, Salt Palace Convention Center(発表確定)
    • Year and Date
      2010-06-07
    • Related Report
      2009 Annual Research Report
  • [Presentation] Repeatability of myocardial blood flow measurements with 3D data acquisition using Rubidium-82 PET2010

    • Author(s)
      Manabe, O.
    • Organizer
      The 57^<th> Annual Meeting of the Society of Nuclear Medicine
    • Place of Presentation
      Salt Lake City, USA, Salt Palace Convention Center(発表確定)
    • Year and Date
      2010-06-06
    • Related Report
      2009 Annual Research Report
  • [Presentation] ルビジウム82心筋PETにおける3次元収集による局所心筋血流定量法の開発2010

    • Author(s)
      加藤千恵次
    • Organizer
      第69回日本医学放射線学会総会,横浜
    • Place of Presentation
      横浜みなとみらいコンベンションセンター
    • Year and Date
      2010-04-09
    • Related Report
      2010 Final Research Report
  • [Presentation] ルビジウム82心筋PETにおける3次元収集による局所心筋血流定量法の開発2010

    • Author(s)
      加藤千恵次
    • Organizer
      第69回日本医学放射線学会総会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2010-04-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] ルビジウム82心筋PETにおける3次元収集による局所心筋血流定量法の開発2010

    • Author(s)
      加藤千恵次
    • Organizer
      第69回日本医学放射線学会総会
    • Place of Presentation
      横浜、パシフィコ横浜(発表確定)
    • Year and Date
      2010-04-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] 82Rubidium PETによる冠動脈疾患検出精度の検討2010

    • Author(s)
      真鍋治
    • Organizer
      第69回日本医学放射線学会総会
    • Place of Presentation
      横浜、パシフィコ横浜(発表確定)
    • Year and Date
      2010-04-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] Rubidium-82 PETにおける局所心筋血流量計測の再現性2009

    • Author(s)
      吉永恵一郎
    • Organizer
      第49回日本核医学会学術総会
    • Place of Presentation
      旭川、旭川市文化会館
    • Year and Date
      2009-10-01
    • Related Report
      2009 Annual Research Report
  • [Presentation] Iterative non-linear least analysis for robust estimation of regional MBF with 82Rb PET2009

    • Author(s)
      Katoh, C.
    • Organizer
      The 56^<th> Annual Meeting of the Society of Nuclear Medicine
    • Place of Presentation
      Toronto, Canada, Metro Toronto Convention Center
    • Year and Date
      2009-06-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] Repeatability of regional rest and hyperemic myocardial blood flow with Rubidium-82 dynamic PET2009

    • Author(s)
      Yoshinaga, K.
    • Organizer
      The 56^<th> Annual Meeting of the Society of Nuclear Medicine
    • Place of Presentation
      Toronto, Canada, Metro Toronto Convention Center
    • Year and Date
      2009-06-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] Iterative non-linear least analysis for robust estimation of Regional MBF with 82Rb PET.2009

    • Author(s)
      Katoh C, Yoshinaga K, Manabe O, Tamaki N
    • Organizer
      56th Seminar of Nuclear Medicine, Toronto
    • Place of Presentation
      Totonto International convention center, Canada
    • Year and Date
      2009-06-07
    • Related Report
      2010 Final Research Report
  • [Presentation] ルビジウム82心筋血流定量ダイナミックPETにおける撮像法の検討2009

    • Author(s)
      加藤千恵次
    • Organizer
      第68回日本医学放射線学会総会,横浜
    • Place of Presentation
      横浜みなとみらいコンベンションセンター
    • Year and Date
      2009-04-17
    • Related Report
      2010 Final Research Report
  • [Presentation] ルビジウム82心筋血流定量ダイナミックPETにおける撮像法の検討2009

    • Author(s)
      加藤千恵次
    • Organizer
      第68回日本医学放射線学会総会
    • Place of Presentation
      横浜、パシフィコ横浜
    • Year and Date
      2009-04-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] ルビジウム82心筋PETにおける局所心筋血流量測定の安定化アルゴリズム開発2008

    • Author(s)
      加藤千恵次
    • Organizer
      第48回日本核医学会総会
    • Place of Presentation
      幕張メッセ、(千葉市)
    • Year and Date
      2008-10-25
    • Related Report
      2008 Annual Research Report
  • [Presentation] New Quantification Algorithm of Regional Myocardial Blood Flow with 82Rubidium PET2008

    • Author(s)
      Katoh C
    • Organizer
      The 55th. Annual meeting, Society of Nuclear Medicine
    • Place of Presentation
      New Orleans Convention center, (USA New Orleans)
    • Year and Date
      2008-06-18
    • Related Report
      2008 Annual Research Report
  • [Remarks] ホームページ等

    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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