| Project/Area Number |
20591439
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Gifu University |
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Principal Investigator |
WATANABE Haruo Gifu University, 医学部附属病院, 医員 (30456529)
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| Co-Investigator(Kenkyū-buntansha) |
KANEMATSU Masayuki 岐阜大学, 医学部附属病院, 准教授 (40252134)
GOSHIMA Satoshi 岐阜大学, 医学部附属病院, 助教 (90402205)
KONDO Hiroshi 岐阜大学, 医学部附属病院, 講師 (20324311)
FUJITA Hiroshi 岐阜大学, 医学系研究科, 教授 (10124033)
TSUGE Yuusuke 岐阜大学, 医学部附属病院, 医員 (80444272)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2010: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | MR imaging / 肝線維症 / 3T / Elastography / Cine-tagging / 肝線維化 / elastography / cine-tagging |
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| Research Abstract |
Objective : To preliminary evaluate the feasibility and usefulness of MR elastography (MRE) of the liver at 3 T with cine-tagging and bending energy (BE) analysis for the evaluation of hepatic fibrosis. Materials and Methods : Twenty-two patients underwent MRE with four different cine-tagging grids on the liver (16- or 20-mm sagittal or coronal). Nine images serially obtained during 1-second exhalation were analyzed to define coordinates of grid intersections. BE values were calculated using thin-plate spline method. BE values were compared among patient groups with different fibrosis stage thresholds. Results : In 22 patients, six had fibrosis score of F0, one had F1, seven had F2, three had F3, and five had F4. Mean BE value with 16-mm sagittal grid was greater with fibrosis score F0 (1.54±0.63) than with〓F1 (0.97±0.12, P=.013) as well as with〓F1 (1.48±0.60) than with〓F2 (0.96±0.36, P=.019). Conclusion : Our results showed that MR elastography with 16-mm sagittal grid and BE analysis had a potential in discrimination of patients with moderate or advanced hepatic fibrosis from those with healthy liver or slight fibrosis.
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