Evaluation of new clinical biomarkers of carbon isotope using high field MR equipment.

• Project/Area Number: 20591445
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: The University of Tokushima
• Principal Investigator: KUBO Hitoshi The University of Tokushima, 大学院・ヘルスバイオサイエンス研究部, 准教授 (00325292)
• Co-Investigator(Kenkyū-buntansha): HARADA Masafumi 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (20228654)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 磁気共鳴医学 / 代謝物 / 炭素同位体 / 超変極 / 代謝評価 / 13C / 磁気共鳴学

Research Abstract

In this project, new clinical biomarkers of carbon isotope using high field MR equipment had been evaluated. We evaluated metabolism of some carbon compounds on cancer cell using 600MHz NMR equipment with hyperpolarizer as basic study. A new 1H-13C surface coil for clinical MR equipment had been made and evaluated as for preparation of clinical study. Analyses of the properties of carbon isotope and the measurement of carbon isotope using clinical MR equipment had been succeeded.

Research Products

• [Journal Article] Selection of endogenous 13C substrates for observation of intracellular metabolism using the dynamic nuclear polarization technique. (2010)
  • Author(s): Harada M, Kubo H, Abe T, Maezawa H, Otsuka H.
  • Journal Title: Jpn J Radiol. 28(2) Pages: 173-179
  • NAID: 50007498096
  • Peer Reviewed
• [Journal Article] 13C-NMR測定による代謝情報可視化の試み (2010)
  • Author(s): 久保均, 原田雅史, 前澤博, 阿部孝政
  • Journal Title: 放射線生物研究 44(4) Pages: 447-459
  • NAID: 40016956272
  • Peer Reviewed
• [Journal Article] 基礎から臨床へ,MRを用いた代謝機能可視化の最前線 (2008)
  • Author(s): 久保均, 原田雅史, 阿部孝政, 西谷弘
  • Journal Title: 四国医学雑誌 64(5,6) Pages: 170-174
  • NAID: 120006335042
  • Peer Reviewed
• [Presentation] 超偏極13Cピルビン酸を用いた乳がん細胞における乳酸脱水素酵素活性度の評価 (2010)
  • Author(s): 久保均, 原田雅史, 阿部孝政, 前澤博
  • Organizer: 第38回日本磁気共鳴医学会大会
  • Place of Presentation: つくば
• [Presentation] MRSを用いた代謝機能の定量評価と画像化 (2010)
  • Author(s): 久保均, 原田雅史, 西谷弘
  • Organizer: 日本機械学会第22回バイオエンジニアリング講演会
  • Place of Presentation: 岡山
• [Presentation] 超偏極13Cピルビン酸を用いた5FUによる乳がん細胞での代謝変化の検出 (2009)
  • Author(s): 久保均, 原田雅史, 阿部孝政, 前澤博, 西谷弘
  • Organizer: 第37回日本磁気共鳴医学会大会
  • Place of Presentation: 横浜