| Project/Area Number |
20591456
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Nara Medical University |
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Principal Investigator |
TAOKA Toshiaki Nara Medical University, 医学部, 准教授 (30305734)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAGAWA Hiroyuki 奈良県立医科大学, 医学部, 准教授 (70231462)
KICHIKAWA Kimihiko 奈良県立医科大学, 医学部, 教授 (10161506)
KISHIMOTO toshifumi 奈良県立医科大学, 医学部, 教授 (60201456)
KIUCHI kuniaki 奈良県立医科大学, 医学部, 助教 (20398449)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | アルツハイマー病 / 拡散テンソル画像 / 大脳辺縁系 / 拡散能 / 拡散異方性 / 認知症 / 拡散テンソルトラクトグラフィー / 鉤状束 / MRI / 脳 / 拡散テンソル異常 / アルツハイマー |
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| Research Abstract |
Our purpose for this study is to correlate the clinical symptoms of Alzheimer disease with diffusion tensor parameters of limbic system. We made clinical study for approximately 400 cases between the period from April 2009 to March 2011 including clinical study such as MMSE (mini mental state examination), conventional MR image, volumetric MR image and MR tensor image. The analysis of diffusion tensor image revealed that there is increase of diffusivity and decrease of fractional anisotropy for uncinate fascicles of Alzheimer disease according to disease severity, as well as anterior cingulum and posterior cingulum. These diffusion parameters correlated with clinical symptoms better than volumetric analysis in our study. Selection of the threshold value proved to have influence for the diffusion parameters in our study. However, as far as using constant threshold value, the diffusion parameter proved to maintain correlation to the clinical symptoms. We also find out that optimal threshold for analysis is fractional anisotropy of 0.15-0.2. We also found that there is agreement between the voxel based analysis (TBSS : Tract-Based Spatial Statistics) and the tract based analysis.
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