Diffusion tensor abnormality in Alzheimer disease-Correlation with clinical symptoms and prognosis-

• Project/Area Number: 20591456
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: Nara Medical University
• Principal Investigator: TAOKA Toshiaki Nara Medical University, 医学部, 准教授 (30305734)
• Co-Investigator(Kenkyū-buntansha): NAKAGAWA Hiroyuki 奈良県立医科大学, 医学部, 准教授 (70231462) ; KICHIKAWA Kimihiko 奈良県立医科大学, 医学部, 教授 (10161506) ; KISHIMOTO toshifumi 奈良県立医科大学, 医学部, 教授 (60201456) ; KIUCHI kuniaki 奈良県立医科大学, 医学部, 助教 (20398449)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: アルツハイマー病 / 拡散テンソル画像 / 大脳辺縁系 / 拡散能 / 拡散異方性 / 認知症 / 拡散テンソルトラクトグラフィー / 鉤状束 / MRI / 脳 / 拡散テンソル異常 / アルツハイマー

Research Abstract

Our purpose for this study is to correlate the clinical symptoms of Alzheimer disease with diffusion tensor parameters of limbic system. We made clinical study for approximately 400 cases between the period from April 2009 to March 2011 including clinical study such as MMSE (mini mental state examination), conventional MR image, volumetric MR image and MR tensor image. The analysis of diffusion tensor image revealed that there is increase of diffusivity and decrease of fractional anisotropy for uncinate fascicles of Alzheimer disease according to disease severity, as well as anterior cingulum and posterior cingulum. These diffusion parameters correlated with clinical symptoms better than volumetric analysis in our study. Selection of the threshold value proved to have influence for the diffusion parameters in our study. However, as far as using constant threshold value, the diffusion parameter proved to maintain correlation to the clinical symptoms. We also find out that optimal threshold for analysis is fractional anisotropy of 0.15-0.2. We also found that there is agreement between the voxel based analysis (TBSS : Tract-Based Spatial Statistics) and the tract based analysis.

Research Products

• [Journal Article] White matter changes in dementia with Lewy bodies and Alzheimer's disease : A tractography-based study. (2011)
  • Author(s): Kiuchi K, Morikawa M, Taoka T, Kitamura S, Nagashima T, Makinodan M, Nakagawa K, Fukusumi M, Ikeshita K, Inoue M, Kichikawa K, Kishimoto T.
  • Journal Title: J Psychiatr Res.(電子出版)
  • Peer Reviewed
• [Journal Article] Magnetic resonance angiography with midsagittal saturation for the assessment of blood flow from superficial temporal artery-to-middle cerebral artery bypass (2010)
  • Author(s): T Akashi, T Taoka, T Miyasaka, K Myochin, M Sakamoto, K Takayama, H Nakagawa, K Kichikawa
  • Journal Title: JCAT 34(1) Pages: 89-92
• [Journal Article] Magnetic resonance plaque imaging to predict the occurrence of the slow-flow phenomenon in carotid artery stenting procedures (2010)
  • Author(s): M Sakamoto, T Taoka, H Nakagawa, K Takayama, T Wada, K Myouchin, T Akashi, T Miyasaka, A Fukusumi, S Iwasaki, K Kichikawa
  • Journal Title: Neuroradiology 52 Pages: 275-283
• [Journal Article] Uncinate fasciculus-correlated congnition in Alzheime's disease : a diffusion tensor imaging study by tractography (2010)
  • Author(s): M Morikawa, K Kiuchi, T Taoka, K Nagauchi, K Kichikawa, T Kishimoto
  • Journal Title: PSYCHOGERIATRICS 10 Pages: 15-20
• [Journal Article] Anatomical evaluation of the dural sinuses in the region of the torcular herophili using 01234567890102030MMSEVSRAD three dimensional CT venography (2010)
  • Author(s): A Fukusumi, T Okudera, S Takahashi, T Taoka, M Sakamoto, H Nakagawa, K Takayama, K Kichikawa, S Iwasaki
  • Journal Title: Academic Radiology 17(9) Pages: 1103-1111
• [Journal Article] Brain surface motion imaging to predict adhesions between meningiomas and the brain surface (2010)
  • Author(s): T Taoka, S Yamada, Y Yamatani, T Akashi, T Miyasaka, T Emura, H Nakase, K Kichikawa
  • Journal Title: Neuroradiology 52 Pages: 1003-1010
• [Journal Article] Brain surface motion imaging to predict adhesions between meningiomas and the brain surface. (2010)
  • Author(s): Taoka T Yamada S, Yamatani Y, Akashi T, Miyasaka T, Emura T, Nakase H, Kichikawa K
  • Journal Title: Neuroradiology Volume: 52 Pages: 1003-10
  • Peer Reviewed
• [Journal Article] Magnetic resonance angiography with midsagittal saturation for the assessment of blood flow from superficial temporal artery-to-middle cerebral artery bypass. (2010)
  • Author(s): Akashi T, Taoka T.Miyasaka T, Myochin K, Sakamoto M, Takayama K, Nakagawa H, Kichikawa K.
  • Journal Title: J Comput Assist Tomogr Volume: 34 Pages: 89-92
  • Peer Reviewed
• [Journal Article] Magnetic resonance plaque imaging to predict the occurrence of the slow-flow phenomenon in carotid artery stenting procedures (2010)
  • Author(s): Sakamoto M, Taoka T, Nakagawa H, Takayama K, Wada T, Myouchin K, Akashi T, Miyasaka T, Fukusumi A, Iawasaki S, Kichikawa K
  • Journal Title: Neuroradiology Volume: 52 Pages: 275-283
  • Peer Reviewed
• [Journal Article] Uncinate fasciculus-correlated congnition in Alzheime's disease : a diffusion tensor imaging study by tractography (2010)
  • Author(s): Morikawa M, Kiuchi K, Taoka T, Nagauchi K, Kichikawa K, Kishimoto T
  • Journal Title: PSYCHOGERIATRICS Volume: 10 Pages: 15-20
  • Peer Reviewed
• [Journal Article] Anatomical evaluation of the dural sinuses in the region of the torcular herophili using three dimensional CT venography (2010)
  • Author(s): Fukusumi A, Okudera S, Takahashi S, Taoka T, Sakamoto M, Nakagawa H, Takayama K, Kichikawa K, Iwasaki S
  • Journal Title: Academic Radiology Volume: 17 Pages: 1103-1111
  • Peer Reviewed
• [Journal Article] Displacement of the facial nerve course bly vesibular schwannoma : preoperative using dissusion tensor tractography (2009)
  • Author(s): T Taoka, H Hirabayashi, H Nakagawa, M Sakamoto, T Akashi, T Miyasaka, K Kichikawa
  • Journal Title: Skull Base 19(Sup1) Pages: 74-74
• [Journal Article] Fractional anisotropy-threshold dependence in tract-based diffusion tensor analysis : evaluation of the uncinate fasciculus in alzheimer disease (2009)
  • Author(s): T Taoka, M Morikawa, T Akashi, T Miyasaka, H Nakagawa, K Kiuchi, T Kishimoto, K Kichikawa
  • Journal Title: AJNR 30 Pages: 1700-1702
• [Journal Article] Abnormalities of the uncinate fasciculus and posterior cingulate fasciculus in mild cognitive impairment and early Alzheimer's disease : A diffusion tensor tractography study (2009)
  • Author(s): K Kiuchi, M Morikawa, T Taoka, T Nagashima, T Yamauchi, M Makinodan, K Norimoto, K Hashimoto, J Kosaka, Y Inoue, M Inoue, K Kichikawa, T Kishimoto
  • Journal Title: Brain Research 1287 Pages: 184-191
• [Journal Article] 連合線維 (2009)
  • Author(s): 田岡俊昭
  • Journal Title: 画像診断 29(5) Pages: 485-498
• [Journal Article] 頭部の3.0T MRI 映像情報 (2009)
  • Author(s): 田岡俊昭、枦山豊、岩城義規、山田卓実、岡本俊成、野義明宏
  • Journal Title: Medical 41(14)
• [Journal Article] Fractional anisotropy--threshold dependence in tract-based diffusion tens or analysis : evaluation of the uncinate fasciculus in Alzheimer disease (2009)
  • Author(s): Taoka T, Morikawa M, Akashi T, 他
  • Journal Title: Am J Neuroradiol 30 Pages: 1700-1703
  • Peer Reviewed
• [Journal Article] Abnormalities of the uncinate fasciculus and posterior cingulate fasciculus in mild cognitive impairment and early Alzheimer's disease : a diffusion tensor tractography study (2009)
  • Author(s): Kiuchi K, Morikawa M, Taoka T, 他
  • Journal Title: Brain Reserch 1287 Pages: 184-191
  • Peer Reviewed
• [Journal Article] 画像検査で脳を探る (2009)
  • Author(s): 田岡俊昭
  • Journal Title: Equibulum Reserch 68 Pages: 113-118
• [Journal Article] 連合線維 (2009)
  • Author(s): 田岡俊昭
  • Journal Title: 画像診断 29 Pages: 485-498
• [Journal Article] 頭部の3.0MRI (2009)
  • Author(s): 田岡俊昭, 枦山豊, 岩城義規, 山田卓実, 岡本俊成, 野儀明宏
  • Journal Title: 映像情報 Medical 41 Pages: 68-75
• [Journal Article] Diffusion tensor tractography of the Meyer loop in cases of temporal lobe resection for temporal lobe epilepsy : correlation between postsurgical visual field defect and anterior limit of Meyer loop on tractography. (2008)
  • Author(s): Taoka T, Sakamoto M, Nakagawa H, NakaseH, Iwasaki S, Takayama K, Taoka K, Hoshida T, Sakaki T, Kichikawa K.
  • Journal Title: AJNR Am J Neuroradiol 29 Pages: 1329-34
  • Peer Reviewed
• [Journal Article] Fractional anisotropy threshold dependence in tract-based diffusion tensor analysis -Evaluation of the uncinate fascicle in Alzheimer disease
  • Author(s): Toshiaki Taoka, Masayuki Morikawa, Toshiaki Akashi, Toshiteru Miyasaka, Hiroyuki Nakagawa, Kuniaki Kiuchi, Toshifumi Kishimoto, Kimihiko Kichikawa
  • Journal Title: AJNR Am J Neuroradiol 2009in press
  • Peer Reviewed
• [Presentation] 側頭葉切除術前後でのMeyer's loopの拡散テンソルトラクトグラフィー-術後師や障害との関連- (2011)
  • Author(s): 田岡俊昭、坂本雅彦、明石敏昭、宮坂俊輝、越智朋子、吉川公彦、田村健太郎、中瀬裕之、星田徹
  • Organizer: 第44回奈良エピレプシークラブ
  • Place of Presentation: 奈良県立医科大学
  • Year and Date: 2011-05-13
• [Presentation] 拡散テンソル法による大脳白質線維路の解剖と臨床応用 (2011)
  • Author(s): 田岡俊昭
  • Organizer: 第14回神奈川ニューロサイエンスジョイントカンファレンス
  • Place of Presentation: 小田急ホテルセンチュリー相模大野
  • Year and Date: 2011-03-09
• [Presentation] 拡散テンソル法による大脳白質線維路の解剖と臨床応用 (2011)
  • Author(s): 田岡俊昭
  • Organizer: 第14回神奈川ニューロサイエンスジョイントカンファレンス
  • Place of Presentation: 小田急ホテルセンチュリー相模大野,神奈川県
  • Year and Date: 2011-03-09
• [Presentation] 側頭葉切除術前後でのMeyer's loopの拡散テンソルトラクトグラフィー -術後師や障害との関連- (2010)
  • Author(s): 田岡俊昭、坂本雅彦、明石敏昭、宮坂俊輝、越智朋子、吉川公彦、田村健太郎、中瀬裕之、星田徹
  • Organizer: 第43回奈良エピレプシークラブ
  • Place of Presentation: 奈良県立医科大学
  • Year and Date: 2010-12-10
• [Presentation] 側頭葉切除術前後でのMeyer's loopの拡散テンソルトラクトグラフィー-術後師や障害との関連- (2010)
  • Author(s): 田岡俊昭、坂本雅彦、明石敏昭、宮坂俊輝、越智朋子、吉川公彦、田村健太郎、中瀬裕之、星田徹
  • Organizer: 第43回奈良エピレプシークラブ
  • Place of Presentation: 奈良県立医科大学,奈良県
  • Year and Date: 2010-12-10
• [Presentation] Tract-specific Diffusion Tensor Analysis of Limbic Fibers and Tract-based Spatial Statistics (TBSS) of Diffusion Tensor Imagein the Cases of Alzheimer Disease : Characteristics and Agreement of the Methods. (2010)
  • Author(s): Taoka T.Emura T, Sakamoto M, Ogawa M, Masada T, Kichikawa K, Akashi T, Miyasaka T
  • Organizer: RSNA
  • Place of Presentation: Chicago, USA
  • Year and Date: 2010-12-02
• [Presentation] Influence of fractional anisotropy threshold for tract based diffusion tensor analysis of uncinate fascicles in Alzheimer disease (2010)
  • Author(s): Taoka T Sakamoto M, Akashi T, Emura T, Miyasaka T, Wada T, Takayama K, Nakagawa H, Kichikawa K
  • Organizer: Symposium Neuroradiologicum
  • Place of Presentation: Bologna, Italy
  • Year and Date: 2010-10-07
• [Presentation] Brain surface motion imaging for pprediction of adhesions between meningiomas and the brain surface. (2010)
  • Author(s): Taoka T.Akashi T, Emura T, Miyasaka T, Iwamura A, Wada, T, Masahiko S, Nakagawa H, Kichikawa K
  • Organizer: Symposium Neuroradiologicum
  • Place of Presentation: Bologna, Italy
  • Year and Date: 2010-10-07
• [Presentation] 拡散テンソル法による脳白質の解析 (2010)
  • Author(s): 田岡俊昭
  • Organizer: 第29回日本医用画像工学会大会
  • Place of Presentation: 東海大学,神奈川県
  • Year and Date: 2010-07-31
• [Presentation] 「アルツハイマー病症例での拡散テンソル画像」-VSRADによる容積評価・鉤状束のテンソル解析・全脳Tract-Based Spatial Statisticsの検討- (2010)
  • Author(s): 田岡俊昭、坂本雅彦、江村朋子、岩村あさみ、中川裕之、和田敬、吉川公彦
  • Organizer: 第17回奈良脳神経ネットワーク研究会
  • Place of Presentation: 厳橿会館
  • Year and Date: 2010-06-25
• [Presentation] 「アルツハイマー病症例での拡散テンソル画像」-VSRADによる容積評価・鉤状束のテンソル解析・全脳Tract-Based Spatial Statisticsの検討- (2010)
  • Author(s): 田岡俊昭、坂本雅彦、江村朋子、岩村あさみ、中川裕之、和田敬、吉川公彦
  • Organizer: 第17回奈良脳神経ネットワーク研究会
  • Place of Presentation: 厳橿会館,奈良県
  • Year and Date: 2010-06-25
• [Presentation] 中枢神経:白質から脳を眺めるー拡散テンソル法での新知識- (2010)
  • Author(s): 田岡俊昭
  • Organizer: 第42回Radiology Update学術講演会
  • Place of Presentation: 東京コンファレンスセンター・品川
  • Year and Date: 2010-03-13
• [Presentation] 白質から脳を眺める-拡散テンソル法での新知識 (2010)
  • Author(s): 田岡俊昭
  • Organizer: Radiology Update 10
  • Place of Presentation: 品川コンファレンスセンター
  • Year and Date: 2010-03-13
• [Presentation] 白質線維と「鉄」 (2010)
  • Author(s): 田岡俊昭
  • Organizer: 第10回山形デジタル画像セミナー
  • Place of Presentation: 山形 パレスグランデール
  • Year and Date: 2010-03-06
• [Presentation] 臨床現場での脳機能画像 (2010)
  • Author(s): 田岡俊昭
  • Organizer: 第11回近畿脳機能研究会
  • Place of Presentation: メルバルク京都
  • Year and Date: 2010-02-19
• [Presentation] 拡散テンソル法による脳白質の解析 (2010)
  • Author(s): 田岡俊昭
  • Organizer: 第29回日本医用画像工学会大会
  • Place of Presentation: 東海大学
• [Presentation] アルツハイマー病での鉤状束の拡散異方性に関してのTract-Based Spatial とTract based analysisの整合性に関する検討 (2010)
  • Author(s): 田岡俊昭、北村聡一郎、木内邦明、森川将行、明石敏昭、江村朋子、和田敬、中川裕之、岸本年史、吉川公彦
  • Organizer: 第39回日本神経放射線学会
  • Place of Presentation: 学術総合センター
• [Presentation] アルツハイマー病での鉤状束の拡散異方性に関しての Tract-Based Spatial と Tract based analysis の整合性に関する検討 (2010)
  • Author(s): 田岡俊昭, 北村聡一郎, 木内邦明, 森川将行, 明石敏昭, 江村朋子, 和田敬, 中川裕之, 岸本年史, 吉川公彦
  • Organizer: 第39回に本神経放射線学会
  • Place of Presentation: 学術総合センター
• [Presentation] MRI読影の基礎 (2010)
  • Author(s): 田岡俊昭
  • Organizer: 第33回日本脳神経CI学会総会
  • Place of Presentation: 学術総合センター
• [Presentation] Tract-specific diffusion tensor analysis of fibers in limbic circuits as a surrogate marker of Alzheimer disease : Comparison with voxel-based morphometry (2009)
  • Author(s): 田岡俊昭
  • Organizer: 北米放射線学会
  • Place of Presentation: アメリカ、シカゴ
  • Year and Date: 2009-12-01
• [Presentation] 頭頸部疾患の画像診断―入門編+先端画像― (2009)
  • Author(s): 田岡俊昭
  • Organizer: 奈良県耳鼻咽喉科医学学術講演会
  • Place of Presentation: ホテルフジタ奈良
  • Year and Date: 2009-10-10
• [Presentation] 連合線維と「鉄」 (2009)
  • Author(s): 田岡俊昭
  • Organizer: 第9回MR Retroscopy勉強会
  • Place of Presentation: HOTEL PLUMM/COSMO.Y
  • Year and Date: 2009-10-03
• [Presentation] 連合線維と「鉄」 (2009)
  • Author(s): 田岡俊昭
  • Organizer: 第9回MR Retroscopy 勉強会
  • Place of Presentation: PLUMM/COSMO.Y HOTEL
  • Year and Date: 2009-10-03
• [Presentation] 拡散テルソンの臨床応用-「役に立つ情報」を目指して- (2009)
  • Author(s): 田岡俊昭
  • Organizer: 第108回東海神経放射線勉強会
  • Place of Presentation: 名古屋市総合リハビリテーションセンター
  • Year and Date: 2009-07-11
• [Presentation] 拡散テンソルの臨床応用―「役に立つ情報」を目指して (2009)
  • Author(s): 田岡俊昭
  • Organizer: 第108回東海神経放射線勉強会
  • Place of Presentation: 名古屋市総合リハビリテーションセンター
  • Year and Date: 2009-07-11
• [Presentation] Influence of fractional anisotropy(FA)threshold in tract based diffusion tensor analysis. -Analysis of uncinate fascicles in Alzheimer disease (2009)
  • Author(s): 田岡俊昭
  • Organizer: ASNR
  • Place of Presentation: アメリカ、ボストン
  • Year and Date: 2009-05-21
• [Presentation] 拡散テンソル法の臨床応用 (2009)
  • Author(s): 田岡俊昭
  • Organizer: 第7回北大阪脳神経画像症例検討会
  • Place of Presentation: 大阪新阪急ホテル
  • Year and Date: 2009-03-13
• [Presentation] Displacement of the facial nerve course by vestibular schwannoa : preoper ative visualization using tensor tractography 9^<th> Congress of the European Skull Base Societ Rotterdam (2009)
  • Author(s): Taoka T, Hirabayasi H, Nakagawa H, Sakamoto M, Akasi T
  • Organizer: 9th Congress of the European Skull Base Society Rotterdam
  • Place of Presentation: オランダ、ロッテルダム
• [Presentation] Evaluation of Fibers in Limbic Circuits by Trct-specific Diffusion Tensor Analysis. -Aceessing severity of Alzheimer disease (2009)
  • Author(s): Taoka T, Akashi T, Miyasaka T, Nakagawa H, Myouchin K, Iwasaki S, Kichikawa K
  • Organizer: ISMRM 17th scientific meeting & exhibition
  • Place of Presentation: アメリカ、ハワイ(ホノルル)
• [Presentation] Selection of Appropriate Fractional Anisotropy(FA)Threshold for Trat Baed Diffusion Tensor Analysis of Uncinte Fascicles in Alheimer Disease (2009)
  • Author(s): Taoka T, Akashi T, Miyasaka T, Nakagawa H, Myouchin K, Iwasaki S, Kichikawa K
  • Organizer: ISMRM
  • Place of Presentation: アメリカ、ハワイ(ホノルル)
• [Presentation] Tract-specific Diffusion Tensor Analysis of Fibers in Limbic Circuits as a Surrogate Marker of Alzheimer Disease : Comparison with Voxel-based Morphometry (2009)
  • Author(s): Taoka T, Akashi, T, H Miyasaka, H Nakagawa, M Hashimoto, Kichikawa K
  • Organizer: 北米放射線学会(RSNA)
  • Place of Presentation: アメリカ、シカゴ
• [Presentation] Tract based analysisでのFA閾値に関する検討 (2008)
  • Author(s): 田岡俊昭, 明石敏昭, 他
  • Organizer: 第36回 日本磁気共鳴医学会大会
  • Place of Presentation: 旭川
  • Year and Date: 2008-09-12
• [Book] 機能性疾患と類縁病態正常圧水頭症 頭部画像診断のここが鑑別ポイント 第6章 (2011)
  • Author(s): 田岡俊昭
  • Publisher: 羊土社
• [Book] Imaging and tissue characterization of atherosclerotic carotid plaque using MR imaging.(S.Takahashi (ed))(Neurovascular Imaging) (2010)
  • Author(s): Taoka T
  • Total Pages: 24
  • Publisher: Springer-Verlag
• [Remarks] ホームページ等