| Project/Area Number |
20591466
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
KOROGI Yukunori University of Occupational and Environmental Health, Japan, 医学部, 教授 (60195691)
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| Co-Investigator(Kenkyū-buntansha) |
OHNARI Norihiro 産業医科大学, 医学部, 助教 (20233207)
KAKEDA Shingo 産業医科大学, 医学部, 講師 (30352313)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 3T MRI / プロトンMRスペクトロスコピー / γ-アミノ酪酸 / グルタミン酸 / 慢性疲労 / 交代制勤務 / MRI / スペクトロスコピー / GABA / 夜勤業務 / スパクトロスコピー |
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| Research Abstract |
Working conditions such as shift work constitute a well-known risk factor for insomnia and excessive daytime sleepiness complaints. We compared brain gamma-aminobutyric acid (GABA), glutamic acid (Glu), glutamine (Gln), and Glx (Glu+Gln) levels in day-shift versus alternate-shift workers with proton magnetic resonance spectroscopy (1H-MRS) at 3T. The study population consisted of 32 healthy adult volunteers (16 day-shift and 16 alternate-shift workers). Each subject underwent MRS conducted using a MEGA-PRESS sequence in the early morning and early evening on the same day. Spectroscopy voxels (3.0 cm×3.0 cm×3.0 cm) were placed in the frontal lobe and parieto-occipital lobe. The GABA/Cr ratio in the frontal lobe was significantly lower for the alternate-shift group than for the day-shift group in the early evening (1.885 vs. 0.875). For the other metabolite ratios (Gln/Cr andGlx/Cr), therewere no significant differences between the two groups regardless of morning or evening schedule. Our preliminary finding represents a possible alteration of GABA content in the brain related to an irregular work schedule.
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