Methodological development of quantitative tracer kinetic analysis in rodents using small animal PET.

• Project/Area Number: 20591469
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: National Institute of Radiological Sciences
• Principal Investigator: SEKI Chie National Institute of Radiological Sciences, 分子イメージング研究センター, 研究員 (40443080)
• Co-Investigator(Renkei-kenkyūsha): HIGUCHI Makoto 独立行政法人放射線医学総合研究所, 分子イメージング研究センター, チームリーダー (10373359) ; KIMURA Yuichi 独立行政法人放射線医学総合研究所, 分子イメージング研究センター, チームリーダー (60205002)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 核医学(PETを含む) / 脳・神経 / アルツハイマー病 / 遺伝子改変マウス / 放射線 / 痴呆 / 薬学

Research Abstract

PET imaging using transgenic mice is one of the advantageous methods for the development of the diagnostic imaging technology of neurological disease. Quantitative analysis of radioligand using arterial input function (AIF) provides precise kinetics in the living organs but the measurement of AIF is difficult in mice. In the present study the measurement of AIF was optimized for kinetic analysis and applied to amyloid β plaque ligand for the evaluation of amyloid β deposition in Alzheimer's disease model mice.

Research Products

• [Presentation] Quantitative evaluation of 11C-PIB binding in amyloid precursor protein transgenic mouse brains. (2010)
  • Author(s): C.Seki, M.Higuchi, M.Tokunaga, S.Hattori, M.Shidahara, R.Nakao, T.Okauchi, J.Maeda, Y.Kimura, I.Kanno, T.Suhara
  • Organizer: The 8th International Symposium on Functional Neuroreceptor Mapping of the Living Brain (NRM2010)
  • Place of Presentation: the Glasgow Hilton Hotel, Glasgow, UK
• [Presentation] Quantitative evaluation of ^<11>C-PIB binding in amyloid precursor proteint ransgenic mouse brains. (2010)
  • Author(s): Chie Seki, et al.
  • Organizer: The 8th International Symposium on Functional Neuroreceptor Mapping of the Living Brain(NRM2010)
  • Place of Presentation: The Glasgow Hilton Hotel, Glasgow, UK
• [Presentation] Quantitative evaluation of 11C-PIB binding in amyloid precursor protein transgenic mouse brains. (2009)
  • Author(s): C.Seki, M.Tokunaga, S.Hattori, M.Shidahara, R.Nakao, T.Okauchi, J.Maeda, M.Higuchi, Y.Kimura, T.Suhara
  • Organizer: Annual Meeting of Society for Neuroscience 2009
  • Place of Presentation: McCormick Place, Chicago, Illinois, USA
• [Presentation] アミロイド前駆体蛋白遺伝子導入マウスにおける11C-PIB脳内結合の定量 (2009)
  • Author(s): 関千江、徳永正希、服部聡子、志田原美保、中尾隆士、岡内隆、前田純、樋口真人、木村裕一、須原哲也
  • Organizer: 第49回日本核医学会学術総会
  • Place of Presentation: 旭川市民文化会館・旭川グランドホテル、旭川市
• [Presentation] Quantitative evaluation of ^<11>C-PIB binding in amyloid precursor protein transgenic mouse brains (2009)
  • Author(s): 関千江, 他
  • Organizer: Annual Meeting of Society for Neuroscience 2009
  • Place of Presentation: McCormick Place, Chicago, Illinois, USA
• [Presentation] アミロイド前駆体蛋白遺伝子導入マウスにおける^<11>C-PIB脳内結合の定量 (2009)
  • Author(s): 関千江, 他
  • Organizer: 第49回日本核医学会学術総会
  • Place of Presentation: 旭川グランドホテル、旭川市
• [Presentation] 小動物定量PET撮影の実際 (2008)
  • Author(s): 関千江
  • Organizer: 第48回日本核医学会学術総会 シンポジウム2「小動物の定量イメージングに向けて-実際の運用と現状-」
  • Place of Presentation: 幕張メッセ、千葉市
  • Year and Date: 2008-10-25
• [Presentation] 小動物定量PET撮影の実際 (2008)
  • Author(s): 関千江
  • Organizer: 第48回日本核医学会学術総会
  • Place of Presentation: 幕張メッセ、千葉市
  • Year and Date: 2008-10-25
• [Presentation] Quantification of ^<11>C-PIB kinetics in mouse brain using metabolite-corrected arterial input function (2008)
  • Author(s): C. Seki
  • Organizer: Nueroreceptor Mapping 2008
  • Place of Presentation: Omni Penn Hotel, Pittsburgh, PA, USA
  • Year and Date: 2008-07-18
• [Presentation] Quantification of 11C-PIB kinetics in mouse brain using metabolite-corrected arterial input function. (2008)
  • Author(s): C.Seki, M.Tokunaga, S.Hattori, M.Shidahara, R.Nakao, J.Maeda, H.Toyama, T.Irie, M.Higuchi, T.Suhara, I.Kanno, Y.Kimura.
  • Organizer: Nueroreceptor Mapping 2008.
  • Place of Presentation: Omni Penn Hotel, Pittsburgh, PA., USA
• [Presentation] 入力関数を用いたマウス脳内の^<11>C-PIB動態の定量解析 (2008)
  • Author(s): 関千江
  • Organizer: 第48回日本核医学会学術総会
  • Place of Presentation: 幕張メッセ、千葉市
• [Book] マウスを対象としたPETリガンド定量動態解析に関する研究(平成21年度国際医療福祉大学大学院医療福祉研究科学位論文) (2010)
  • Author(s): 関千江