Methodological development of quantitative tracer kinetic analysis in rodents using small animal PET.
| Project/Area Number |
20591469
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | National Institute of Radiological Sciences |
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Principal Investigator |
SEKI Chie National Institute of Radiological Sciences, 分子イメージング研究センター, 研究員 (40443080)
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| Co-Investigator(Renkei-kenkyūsha) |
HIGUCHI Makoto 独立行政法人放射線医学総合研究所, 分子イメージング研究センター, チームリーダー (10373359)
KIMURA Yuichi 独立行政法人放射線医学総合研究所, 分子イメージング研究センター, チームリーダー (60205002)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 核医学(PETを含む) / 脳・神経 / アルツハイマー病 / 遺伝子改変マウス / 放射線 / 痴呆 / 薬学 |
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| Research Abstract |
PET imaging using transgenic mice is one of the advantageous methods for the development of the diagnostic imaging technology of neurological disease. Quantitative analysis of radioligand using arterial input function (AIF) provides precise kinetics in the living organs but the measurement of AIF is difficult in mice. In the present study the measurement of AIF was optimized for kinetic analysis and applied to amyloid β plaque ligand for the evaluation of amyloid β deposition in Alzheimer's disease model mice.
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Report
(4 results)
Research Products
(12 results)
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[Presentation] Quantitative evaluation of 11C-PIB binding in amyloid precursor protein transgenic mouse brains.2010
Author(s)
C.Seki, M.Higuchi, M.Tokunaga, S.Hattori, M.Shidahara, R.Nakao, T.Okauchi, J.Maeda, Y.Kimura, I.Kanno, T.Suhara
Organizer
The 8th International Symposium on Functional Neuroreceptor Mapping of the Living Brain (NRM2010)
Place of Presentation
the Glasgow Hilton Hotel, Glasgow, UK
Related Report
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[Presentation] Quantitative evaluation of 11C-PIB binding in amyloid precursor protein transgenic mouse brains.2009
Author(s)
C.Seki, M.Tokunaga, S.Hattori, M.Shidahara, R.Nakao, T.Okauchi, J.Maeda, M.Higuchi, Y.Kimura, T.Suhara
Organizer
Annual Meeting of Society for Neuroscience 2009
Place of Presentation
McCormick Place, Chicago, Illinois, USA
Related Report
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[Presentation] Quantification of 11C-PIB kinetics in mouse brain using metabolite-corrected arterial input function.2008
Author(s)
C.Seki, M.Tokunaga, S.Hattori, M.Shidahara, R.Nakao, J.Maeda, H.Toyama, T.Irie, M.Higuchi, T.Suhara, I.Kanno, Y.Kimura.
Organizer
Nueroreceptor Mapping 2008.
Place of Presentation
Omni Penn Hotel, Pittsburgh, PA., USA
Related Report
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