Effects of selective bone marrow cells transplantation
| Project/Area Number |
20591509
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Asahikawa Medical College |
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Principal Investigator |
INAGAKI Mitsuhiro Asahikawa Medical College, 医学部, 非常勤講師 (80261410)
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| Co-Investigator(Kenkyū-buntansha) |
OGAWA Katsuhiro 旭川医科大学, 医学部, 名誉教授 (50045514)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 移植外科学 / 骨髄細胞移植 / 分離肝細胞移植 / 無アルブミンラット / レトルリシン / 70%部分肝切除 / 急性肝障害 / PCR / 免疫組織染色 / 急性肝傷害 / 分離幹細胞移植 / レトルリシン70%部分肝切除 |
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| Research Abstract |
The therapeutic effects of bone marrow and hepatocyte transplantation were investigated regarding the treatment of retrorsine-partial hepatectomy-induced liver injury. Analbuminemic F344alb rats were given 2 doses of retrorsine 2 wk apart, followed 4 wk later by transplantation with F344 rat bone marrow cells or hepatocytes immediately after a two-thirds hepatectomy. Both bone marrow and isolated hepatocytes transplantation into the liver could prevent acute hepatic injury, conceivably due to a paracrine mechanism.
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Report
(4 results)
Research Products
(13 results)
