Effects of selective bone marrow cells transplantation

• Project/Area Number: 20591509
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General surgery
• Research Institution: Asahikawa Medical College
• Principal Investigator: INAGAKI Mitsuhiro Asahikawa Medical College, 医学部, 非常勤講師 (80261410)
• Co-Investigator(Kenkyū-buntansha): OGAWA Katsuhiro 旭川医科大学, 医学部, 名誉教授 (50045514)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 移植外科学 / 骨髄細胞移植 / 分離肝細胞移植 / 無アルブミンラット / レトルリシン / 70%部分肝切除 / 急性肝障害 / PCR / 免疫組織染色 / 急性肝傷害 / 分離幹細胞移植 / レトルリシン70%部分肝切除

Research Abstract

The therapeutic effects of bone marrow and hepatocyte transplantation were investigated regarding the treatment of retrorsine-partial hepatectomy-induced liver injury. Analbuminemic F344alb rats were given 2 doses of retrorsine 2 wk apart, followed 4 wk later by transplantation with F344 rat bone marrow cells or hepatocytes immediately after a two-thirds hepatectomy. Both bone marrow and isolated hepatocytes transplantation into the liver could prevent acute hepatic injury, conceivably due to a paracrine mechanism.

Research Products

• [Journal Article] The replacement of the liver parenchyma in analbuminemic rats with allogenic hepatocytes is facilitated by intrabone marrow-bone marrow transplantation. (2011)
  • Author(s): M.Inagaki, H.Furukawqa, Y.Satake, Y.Okada, S.Chiba, N.Nishikawa, K.Ogawa
  • Journal Title: Cell Transplantation Volume: (In press)
  • NAID: 120006658766
  • Peer Reviewed
• [Journal Article] Effects of bone marrow and hepatocytes transplantation on liver injury (2009)
  • Author(s): B.Zhang, M.Inagaki, B.Jiang, M.Miyakoshi, J.Arikura, K.Ogawa, S.Kasai
  • Journal Title: Journal of Surgical Research 157 Pages: 71-80
  • NAID: 120003203366
• [Journal Article] Effects of bone marrow and hepatocytes transplantation on liver injury. (2009)
  • Author(s): B.Zhang, M.Inagaki, B.Jiang, M.Miyakoshi, J.Arikura, K.Ogawa, S.Kasai
  • Journal Title: Journal of Surgical Research 157 Pages: 71-80
  • NAID: 120003203366
  • Peer Reviewed
• [Journal Article] The replacement of the liver parenchyma in analbuminemic rats with allogenic hepatocytes is facilitated by intrabone marrow-bone marrow transplantation
  • Author(s): M.Inagaki, H.Furukawa, Y.Satake, Y.Okada, S.Ciba, N.Nishikawa, K.Ogawa
  • Journal Title: Cell Transplantation (in press)
  • NAID: 120006658766
• [Journal Article] Effects of bone marrow and hepatocytes transplantation on liver injury
  • Author(s): B. Zhang, M. Inagaki, B. Jiang, M. Miyakoshi, J. Arikura, K. Ogawa, S. Kasai
  • Journal Title: Journal of Surgical Research (In press)
  • NAID: 120003203366
  • Peer Reviewed
• [Presentation] ラット同種肝細胞移植による宿主肝細胞置換につい-同種骨髄細胞移植による免疫寛容の誘導- (2010)
  • Author(s): 稲垣光裕、古川博之、西川祐司
  • Organizer: JDDW2010横浜
  • Place of Presentation: 横浜
  • Year and Date: 2010-10-13
• [Presentation] ラット同種肝細胞移植による宿主肝細胞置換について-同種骨髄細胞移植による免疫寛容の誘導- (2010)
  • Author(s): 稲垣光裕、古川博之、西川祐司
  • Organizer: JDDW2010横浜(panel discussion)
  • Place of Presentation: 横浜
  • Year and Date: 2010-10-13
• [Presentation] 骨髄細胞移植した無アルブミンラットへのadult allogenic hepatocyte移植に関する検討 (2009)
  • Author(s): 稲垣光裕、佐竹由康、岡田陽子、葛西眞一、山本雅大、小川勝洋
  • Organizer: 第16回肝細胞研究会
  • Place of Presentation: 山形
  • Year and Date: 2009-06-26
• [Presentation] 骨髄細胞移植した無アルブミンラット(f344alb)へのadult allogenic hepatocyte移植に関する基礎的検討 (2009)
  • Author(s): 稲垣光裕、佐竹由康、岡田陽子、葛西眞一、山本雅大、小川勝洋
  • Organizer: 第16回肝細胞研究会
  • Place of Presentation: 山形
  • Year and Date: 2009-06-26
• [Presentation] The effect of bone marrow and hepatocyte transplantation against retrorsine-partial hepatectomy induced liver injury in analbuminemic rats (2009)
  • Author(s): M.Inagaki, B.Zhang, J.Arikura, K.Ogawa
  • Organizer: The 10^<th> international cell transplant congress and 36^<th> annual meeting of JSOPMB (Symposium)
  • Place of Presentation: Okayama(Japan)
  • Year and Date: 2009-04-20
• [Presentation] The effect of bone marrow and hepatocyte transplantation against Retrorsine-partial hepatectomy induced liver injury in analbuminemic rats. (2009)
  • Author(s): M.Inagaki, B.Zhang, J.Arikura, K.Ogawa
  • Organizer: The 10^<th> international cell transplant congress and the 36^<th> annual meeting of JSOPMB(Symposium)
  • Place of Presentation: Okayama
  • Year and Date: 2009-04-20
• [Presentation] Retmrsine/70%部分肝切除による無アルブミンラット肝障害モデルへの骨髄由来細胞および分離肝細胞移植効果について (2008)
  • Author(s): 稲垣光裕、Biao Zhang、有倉潤、小川勝洋、葛西眞一
  • Organizer: 第15回肝細胞研究会(シンポジウム)
  • Place of Presentation: 静岡
  • Year and Date: 2008-06-27
• [Presentation] Retrorsine投与により肝再生抑制された無アルブミンラット門脈内への正常ラット由来骨髄細胞移植及び分離肝細胞移植のおよび長期効果について (2008)
  • Author(s): 稲垣光裕、Biao Zhang、有倉潤、葛西眞一
  • Organizer: 第108回日本外科学会定期学術集会(サージカルフォーラム)
  • Place of Presentation: 長崎
  • Year and Date: 2008-05-16