| Project/Area Number |
20591574
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
NAKAMORI Mikihito Wakayama Medical University, 医学部, 講師 (10322372)
|
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| Co-Investigator(Kenkyū-buntansha) |
YAMAUE Hiroki 和歌山県立医科大学, 医学部, 教授 (20191190)
IWAHASHI Makoto 和歌山県立医科大学, 医学部, 講師 (70244738)
NAKAMURA Masaki 和歌山県立医科大学, 医学部, 助教 (80364090)
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| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | スキルス胃癌 / ウイルス療法 / 腹膜播種 / 探索的研究 / ヘルペスウイルス |
|---|
| Research Abstract |
Scirrhous gastric cancer, a diffusely infiltrating type of poorly differentiated gastric cancer also known as linitis plastic-type cancer is characterized by rapid cancer cell infiltration. Therefore, scirrhous gastric cancer carries a worse prognosis than other types of gastric cancers. Viral therapy for scirrhous gastric cancer is a promising strategy. Viral therapy using herpes simplex virus-1 (HSV-1) is especially practical for clinical application when its safety and therapeutic potency are warranted. We have recently investigated arming oncolytic herpes virus engineered by taxane-mediated molecule.
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