| Project/Area Number |
20591582
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
HANAGIRI Takeshi (2009-2010) University of Occupational and Environmental Health, Japan, 医学部, 准教授 (30299614)
杉尾 賢二 (2008) University of Occupational and Environmental Health, Japan, 医学部, 准教授 (70235927)
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| Co-Investigator(Kenkyū-buntansha) |
SUGIO Kenji 国立病院機構九州がんセンター, 臨床研究部, 部長 (70235927)
ONO Kenji 産業医科大学, 医学部, 助教 (40369062)
SHIGEMATSU Yoshiki 産業医科大学, 医学部, 助教 (10546469)
YASUMOTO Kosei 産業医科大学, 医学部, 名誉教授 (30150452)
OHGA Takeshi 九州大学, 医学部, 助教 (60335958)
花桐 武志 産業医科大学, 医学部, 講師 (30299614)
|
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| Co-Investigator(Renkei-kenkyūsha) |
NOZOE Tadahiro 産業医科大学, 医学部, 非常勤医師 (90325457)
YASUD Manabu 産業医科大学, 医学部, 非常勤医師 (50352307)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 食道癌 / 扁平上皮癌 / ERalpha / ERbeta / 抗腫瘍効果 / topoisomerase-I / topoisomerase-II / HLA |
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| Research Abstract |
In this study, expression of topoisomerase-I, topoisomerase-IIα, and HLA class I was investigated for establishment of novel treatment strategy for patients with esophageal cancer. The positive expression of topoisomerase-I was identified in 62% of the patients, and the expression of topoisomerase-I was not prognostic factor. The positive expression of topoisomerase-IIαwas observed in 62% of the patients, and the patients with positive expression of topoisomerase-IIαhad a tendency of favorable prognosis. The positive expression of HLA class I showed a tendency of favorable prognosis.
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