Establishment of novel treatment strategy based on the biological characteristics of esophageal squamous cell carcinoma.

• Project/Area Number: 20591582
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: University of Occupational and Environmental Health, Japan
• Principal Investigator: HANAGIRI Takeshi (2009-2010) University of Occupational and Environmental Health, Japan, 医学部, 准教授 (30299614); 杉尾 賢二 (2008) University of Occupational and Environmental Health, Japan, 医学部, 准教授 (70235927)
• Co-Investigator(Kenkyū-buntansha): SUGIO Kenji 国立病院機構九州がんセンター, 臨床研究部, 部長 (70235927) ; ONO Kenji 産業医科大学, 医学部, 助教 (40369062) ; SHIGEMATSU Yoshiki 産業医科大学, 医学部, 助教 (10546469) ; YASUMOTO Kosei 産業医科大学, 医学部, 名誉教授 (30150452) ; OHGA Takeshi 九州大学, 医学部, 助教 (60335958) ; 花桐 武志 産業医科大学, 医学部, 講師 (30299614)
• Co-Investigator(Renkei-kenkyūsha): NOZOE Tadahiro 産業医科大学, 医学部, 非常勤医師 (90325457) ; YASUD Manabu 産業医科大学, 医学部, 非常勤医師 (50352307)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2008: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
• Keywords: 食道癌 / 扁平上皮癌 / ERalpha / ERbeta / 抗腫瘍効果 / topoisomerase-I / topoisomerase-II / HLA

Research Abstract

In this study, expression of topoisomerase-I, topoisomerase-IIα, and HLA class I was investigated for establishment of novel treatment strategy for patients with esophageal cancer. The positive expression of topoisomerase-I was identified in 62% of the patients, and the expression of topoisomerase-I was not prognostic factor. The positive expression of topoisomerase-IIαwas observed in 62% of the patients, and the patients with positive expression of topoisomerase-IIαhad a tendency of favorable prognosis. The positive expression of HLA class I showed a tendency of favorable prognosis.

Research Products

• [Journal Article] 他臓器重複癌を有する食道癌切除例 (2011)
  • Author(s): 小野憲司,竹中賢,横山えりな,岡壮一,馬場哲郎,宗哲哉,宗知子,浦本秀隆,竹之山光広,花桐武志,安元公正
  • Journal Title: 胸部外科 4 Pages: 93-96
  • Peer Reviewed
• [Journal Article] 臓器重複癌を有する食道癌切除例 (2011)
  • Author(s): 小野憲司
  • Journal Title: 胸部外科 Volume: 64 Pages: 93-96
  • Peer Reviewed
• [Journal Article] Prospective phase II study of gefitinib in non-small cell lung cancer with epidermal growth factor receptor gene mutations. (2009)
  • Author(s): Sugio K, Uramoto H, Onitsuka T, Mizukami M, Ichiki Y, Sugaya M, Yasuda M, Takenoyama M, Oyama T, Hanagiri T, Yasumoto K
  • Journal Title: Lung Cancer 64 Pages: 314-318
  • Peer Reviewed
• [Journal Article] Association between estrogen receptor-beta expression and epidermal growth factor receptor mutation in the postoperative prognosis of adenocarcinoma of the lung. (2009)
  • Author(s): Nose N, Sugio K, Oyama T, Nozoe T, Uramoto H, Iwata T, Onitsuka T, Yasumoto K
  • Journal Title: J Clin Oncol 27 Pages: 411-417
  • Peer Reviewed
• [Journal Article] Association Between Estrogen Receptor-{beta} Expression and Epidermal Growth Factor Receptor Mutation in the Postoperative Prognosis of Adenocarcinoma of the Lung (2009)
  • Author(s): Nose N
  • Journal Title: J Clin Oncol 27(3) Pages: 411-417
  • Peer Reviewed
• [Journal Article] Prospective phase II study of gefitinib in non-small cell lung cancer with epidermal growth factor receptor gene mutations (2009)
  • Author(s): Sugio K
  • Journal Title: Lung Cancer (in press)
  • Peer Reviewed
• [Journal Article] Expression of Cytochrome P450 in non-small cell lung cancer. (2008)
  • Author(s): Oyama T, Sugio K, Isse T, Matsumoto A, Nose N, Uramoto H, Nozoe T, Morita M, Kagawa N, Osaki T, Muto M, Yasumoto K, Kawamoto T
  • Journal Title: Front Biosci 13 Pages: 5787-5793
  • Peer Reviewed
• [Journal Article] Acute lung injury following an esophagectomy for esophageal cancer, with special reference to the clinical factors and cytokine levels of peripheral blood and pleural drainage fluid. (2008)
  • Author(s): Morita M
  • Journal Title: Disease of Esophagus 21 Pages: 30-36
  • Peer Reviewed
• [Journal Article] Expression of cytochrome P450 in non-small cell lung cancer. (2008)
  • Author(s): Oyama T
  • Journal Title: Frontiers in Bioscience 13 :, 2008. 13 Pages: 5787-5793
  • Peer Reviewed
• [Presentation] 食道癌におけるHLA class I分子の発現に関する検討. (2010)
  • Author(s): 小野憲司,花桐武志,永田好香,下川秀彦,重松義紀,馬場哲郎,浦本秀隆,竹之山光広,安元公正
  • Organizer: 第48回日本癌治療学会学術集会
  • Place of Presentation: 京都
• [Presentation] 食道癌におけるToposomeraselの発現に関する検討. (2010)
  • Author(s): 小野憲司,下川秀彦,馬場哲郎,重松義紀,宗哲哉,浦本秀隆,宗知子,竹之山光広,花桐武志,安元公正
  • Organizer: 第64回日本食道学会学術集会
  • Place of Presentation: 久留米
• [Presentation] 食道癌におけるToposomerase1の発現に関する検討 (2010)
  • Author(s): 小野憲司
  • Organizer: 第64回日本食道学会学術集会
  • Place of Presentation: 石橋文化ホール(久留米)
• [Presentation] 食道癌におけるHLA class I分子の発現に関する検討 (2010)
  • Author(s): 小野憲司
  • Organizer: 第48回日本癌治療学会学術集会京都
  • Place of Presentation: 国立京都国際会館(京都)
• [Presentation] 当科における食道癌と他臓器重複癌症例の検討. (2009)
  • Author(s): 小野憲司,花桐武志,馬場哲郎,宗哲哉,浦本秀隆,宗知子,竹之山光広,安元公正
  • Organizer: 第62回日本胸部外科学会定期学術集会
  • Place of Presentation: 横浜
• [Presentation] 当科における食道癌と他臓器重複癌症例の検討 (2009)
  • Author(s): 小野憲司
  • Organizer: 第62回日本胸部外科学会定期学術集会
  • Place of Presentation: パシフィコ横浜(横浜市)
• [Presentation] 食道扁平上皮癌におけるα、β、γカテニン発現の意義. (2008)
  • Author(s): 野添忠浩,鬼塚貴光,岩田輝男,水上真紀子,市来嘉伸,安田学,浦本秀隆,竹之山光広,小山倫浩,花桐武志,杉尾賢二,安元公正
  • Organizer: 第108回日本外科学会定期学術集会
  • Place of Presentation: 長崎
• [Presentation] 食道扁平上皮癌におけるα、β、γカテニン発現の意義 (2008)
  • Author(s): 野添忠浩
  • Organizer: 第108回日本外科学会定期学術集会
  • Place of Presentation: 長崎