Mesenchymal stem cells infected with modified adenoviruses as carrier cells that target human gastrointestinal tumors
| Project/Area Number |
20591585
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Chiba Cancer Center (Research Institute) |
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Principal Investigator |
TAGAWA Masatoshi Chiba Cancer Center (Research Institute), がん治療開発グループ, 部長 (20171572)
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| Co-Investigator(Kenkyū-buntansha) |
SHIMADA Hideaki 東邦大学, 医学部, 教授 (20292691)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 食道がん / がん治療 / 遺伝子 / アデノウイルス / キャリアー細胞 / 遺伝子治療 / 制限増殖型ウイルス / 間葉系幹細胞 / アポトーシス / 細胞傷害活性 / 遺伝子医薬 / コクサキーアデノウイルス受容体 / CD46分子 / p53遺伝子 / 初期応答遺伝子 / ウイルス受容体 |
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| Research Abstract |
Majority of human solid tumors, when clinically in an advanced stage, is resistant to most of conventional therapies and consequently improved prognosis with a novel strategy is a crucial target in clinical settings. We developed type 5 adenoviruses which replicated preferentially within tumors and then examined the anti-tumor effects. We also modified the adenoviruses of which the receptor-binding site was replaced with that of type 35 adenoviruses, which subsequently increased the infectivity to human tumors due to a high receptor expression in the tumors. We examined a possible advantage to use carrier cells which were infected with such adenoviruses.
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Report
(4 results)
Research Products
(20 results)
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[Journal Article] Combinatory cytotoxic effects produced by E1B-55kDa-deleted adenoviruses and chemotherapeutic agents are dependent on the agents in esophageal carcinoma.2010
Author(s)
Ma G., Kawamura K., Li Q., Okamoto S., Suzuki N., Kobayashi H., Liang M., Tada Y., Tatsumi K., Hiroshima K., Shimada H., Tagawa M.
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Journal Title
Cancer Gene Ther. 17
Pages: 803-813
Related Report
Peer Reviewed
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