In Carcinogenesis of colon and rectum, abnormality of tumor cell polarity is induced by expression change of aPKC/PAR system
Project/Area Number |
20591592
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Digestive surgery
|
Research Institution | Yokohama City University |
Principal Investigator |
ICHIKAWA Yasushi Yokohama City University, 医学研究科, 准教授 (70254208)
|
Co-Investigator(Kenkyū-buntansha) |
NAGASHIMA Yoji 横浜市立大学, 医学研究科, 准教授 (10217995)
|
Project Period (FY) |
2008 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | 大腸腺腫 / aPKC / 細胞極性 / 大腸腫瘍 / 大腸癌 |
Research Abstract |
Both adenoma and cancer in situ of LSTs showed a unique growth morphology as neoplastic cells tend to spread along the surface of the lumen and 2 layer structure, which is different from expanding growth pattern showed by polypoid tumor or invasive cancer. Those morphological characteristics were built up by adequate coexpression of beta-catenin, type IV collagen and aPKC lambda/iota.
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Report
(4 results)
Research Products
(10 results)
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[Journal Article] High expression of atypical protein kinase C lambda/iota in gastric cancer as a prognostic factor for recurrence.2010
Author(s)
Takagawa R, Akimoto K, Ichikawa Y, Akiyama H, Kojima Y, Ishiguro H, Inayama Y, Aoki I, Kunisaki C, Endo I, Nagashima Y, Ohno S.
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Journal Title
Ann Surg Oncol. 17(1)
Pages: 81-88
Related Report
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[Journal Article] The overexpression and altered localization of the atypical protein kinase C lambda/iota in breast cancer correlates with the pathologic type of these tumors.2008
Author(s)
Kojima Y, Akimoto K, Nagashima Y, Ishiguro H, Shirai S, Chishima T, Ichikawa Y, Ishikawa T, Sasaki T, Kubota Y, Inayama Y, Aoki I, Ohno S, Shimada H.
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Journal Title
Hum Pathol. 39(6)
Pages: 824-831
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