In Carcinogenesis of colon and rectum, abnormality of tumor cell polarity is induced by expression change of aPKC/PAR system

• Project/Area Number: 20591592
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Yokohama City University
• Principal Investigator: ICHIKAWA Yasushi Yokohama City University, 医学研究科, 准教授 (70254208)
• Co-Investigator(Kenkyū-buntansha): NAGASHIMA Yoji 横浜市立大学, 医学研究科, 准教授 (10217995)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 大腸腺腫 / aPKC / 細胞極性 / 大腸腫瘍 / 大腸癌

Research Abstract

Both adenoma and cancer in situ of LSTs showed a unique growth morphology as neoplastic cells tend to spread along the surface of the lumen and 2 layer structure, which is different from expanding growth pattern showed by polypoid tumor or invasive cancer. Those morphological characteristics were built up by adequate coexpression of beta-catenin, type IV collagen and aPKC lambda/iota.

Research Products

• [Journal Article] High expression of atypical protein kinase C lambda/iota in gastric cancer as a prognostic factor for recurrence. (2010)
  • Author(s): Takagawa R, Akimoto K, Ichikawa Y, Akiyama H, Kojima Y, Ishiguro H, Inayama Y, Aoki I, Kunisaki C, Endo I, Nagashima Y, Ohno S.
  • Journal Title: Ann Surg Oncol. 17(1) Pages: 81-88
• [Journal Article] The overexpression and altered localization of the atypical protein kinase C lambda/iota in breast cancer correlates with the pathologic type of these tumors. (2008)
  • Author(s): Kojima Y, Akimoto K, Nagashima Y, Ishiguro H, Shirai S, Chishima T, Ichikawa Y, Ishikawa T, Sasaki T, Kubota Y, Inayama Y, Aoki I, Ohno S, Shimada H.
  • Journal Title: Hum Pathol. 39(6) Pages: 824-831
• [Presentation] In laterally spreading type tumors (LSTs) of the colon or the rectum, expression of the atypical protein kinase C lambda/iota is correlated to expression of beta-catenin and Type IV collagen. (2011)
  • Author(s): 市川靖史, 長嶋洋治, et al.
  • Organizer: American Association Cancer Research, 102nd Annual Meeting
  • Place of Presentation: Orland
• [Presentation] Expression of the atypical protein kinase C combined with expression of other factors is important for determination of structures in lateral spreading type tumors of the colon or the rectum (2010)
  • Author(s): Yasushi Ichikawa, et al
  • Organizer: American Association Cancer Research, 101^<st> Annual Meeting 2010
  • Place of Presentation: Washington DC.United States of America
  • Year and Date: 2010-04-21
• [Presentation] Lateral Spreading typeTumors(LST)におけるatypical protein kinase C lambda/iotaの発現 (2010)
  • Author(s): 市川靖史, 長嶋洋治, ほか
  • Organizer: 第65回日本消化器外科学会総会
• [Presentation] Expression of the atypical protein kinase C combined with expression of other factors is important for determination of structures in lateral spreading type tumors of the colon or the rectum. (2010)
  • Author(s): Ichikawa Y., Nagashima Y, et.al
  • Organizer: American Association Cancer Research, 101st Annual Meeting
  • Place of Presentation: Washington DC.
• [Presentation] Expression of the atypical protein kinase C in lateral spreading type tumors of the colon or the rectum (2009)
  • Author(s): Ichikawa Y., et al
  • Organizer: American Association for Cancer Research, 100^<st> Annual Meeting
  • Place of Presentation: Denver, Colorado
  • Year and Date: 2009-04-19
• [Presentation] Experssion of the atypical protein kinase C lambda/iota in colorectal lateral spreading tumor (2009)
  • Author(s): Ichikawa Y., et al
  • Organizer: 100^<th> Anual Meeting 2009 for American Association for Cancer Reasearch
  • Place of Presentation: Colorado ConventionCenter, Denver, USA
  • Year and Date: 2009-04-19
• [Presentation] 大腸lateral spreading tumor(LST)におけるatypical protein kinase C発現の意義(Expression of the atypical protein kinase C in lateral spreading type tumors of the colon or the rectum) (2009)
  • Author(s): 市川靖史、長嶋洋治, 他
  • Organizer: 第68回日本癌学会総会
• [Presentation] Expression of the atypical protein kinase C in lateral spreading type tumors of the colon or the rectum. (2009)
  • Author(s): 市川靖史, 長嶋洋治, et al
  • Organizer: American Association for Cancer Research, 100st Annual Meeting
  • Place of Presentation: Denver, Colorado