| Project/Area Number |
20591611
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Kobe University |
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Principal Investigator |
KU Yonson Kobe University, 大学院・医学研究科, 教授 (40195615)
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| Co-Investigator(Kenkyū-buntansha) |
FUKUMOTO Takumi 神戸大学, 大学院・医学研究科, 准教授 (70379402)
KUSUNOKI Nobuya 神戸大学, 医学部付属病院, 准教授 (10379406)
KIDO Masahiro 神戸大学, 医学部付属病院, 講師 (00403246)
尾形 哲 神戸大学, 医学部附属病院, 医員 (40444583)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 肝細胞癌 / 再発肝癌 / 経皮的肝灌流化学療法 / 肝内再発 / 肝切除 / 経皮的肝灌流 |
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| Research Abstract |
Hepatic resection remains the only therapeutic option for improved survival in the patients with hepatocellular carcinoma (HCC). However, a high incidence of recurrence after resection is life-threatening problem. In this study, we proposed percutaneous isolated hepatic perfusion (PIHP), a novel and potent regional chemotherapeutic regimen can achieve the protection against high-risk group for the recurrence of HCC after resection. PIHP after hepatic resection improved overall survival. In conclusion, dual treatment of resection and PIHP can offer an innovative strategy for resectable HCC treatment.
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