Combination adjuvant therapy using chemotherapy and immunotherapy for pancreatic cancer: assessment of safety and efficacy.

• Project/Area Number: 20591623
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: The University of Tokyo
• Principal Investigator: AOKI Taku The University of Tokyo, 医学部附属病院, 講師 (30302722)
• Co-Investigator(Kenkyū-buntansha): HASEGAWA Kiyoshi 東京大学, 医学部附属病院, 准教授 (20292906) ; KOKUDO Norihiro 東京大学, 医学部附属病院, 教授 (00205361) ; KAKIMI Kazuhiro 東京大学, 医学部附属病院, 特任准教授 (80273358)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 膵臓外科学 / 化学療法 / 免疫療法 / 膵癌 / 補助化学療法

Research Abstract

An adjuvant therapy using combination of Gemcitabine and auto γδ T lymphocyte immunotherapy was conducted for postoperative patients with pancreatic cancer. Twenty-two patients were enrolled and actually 11 patients received the combination therapy. The safety of the therapy was confirmed, but the benefit for disease-free survival was unclear. Further follow-up will be needed.

Research Products

• [Journal Article] Adoptive immunotherapy for advanced non-small cell lung cancer using zoledronate-expanded γδT cells : a phase I clinical study. (2011)
  • Author(s): Sakamoto M, Nakajima J, Murakawa T, Fukami T, Yoshida Y, Murayama T, Takamoto S, Matsushita H, Kakimi K
  • Journal Title: J Immunother 34(2) Pages: 202-211
  • Peer Reviewed
• [Journal Article] A phase I study of adoptive immunotherapy for recurrent non-small cell lung cancer patients with autologous gammadelta T cells. (2010)
  • Author(s): Nakajima J, Murakawa T, Fukami T, Goto S, Kaneko T, Yoshida Y, Takamoto S, Kakimi K
  • Journal Title: Eur j cardiothorac Surg 37(5) Pages: 1191-1197
  • Peer Reviewed
• [Journal Article] A phase I study of adoptive immunotherapy for recurrent non-small-cell lung cancer patients with autologous gammadelta T cells (2010)
  • Author(s): Nakajima J
  • Journal Title: Eur J Cardiothorac Surg Volume: 37 Pages: 1191-1197
  • Peer Reviewed
• [Journal Article] Adoptive immnotherapy for advanced non-small-cell lung cancer using zelodronate-expanded gammadelta T cells : a phase I clinical study. (2010)
  • Author(s): Sakamoto M
  • Journal Title: J Immunother Volume: 34 Pages: 201-211
  • Peer Reviewed
• [Journal Article] A phase I study of adoptive immunotherapy for recurrent non-small-cell lung cancer patients with autologous gammadelta T cells. (2010)
  • Author(s): Nakajima J
  • Journal Title: Eur J Cardiothorac Surg 3-Feb(in print)
  • Peer Reviewed
• [Journal Article] がん特異的免疫療法の将来像 (2009)
  • Author(s): 國土典宏
  • Journal Title: Cancer Review(日経メディカル) 8月号 Pages: 35-35
• [Journal Article] Impact of culture medium on the expansion of T cells for immunotherapy. (2009)
  • Author(s): Sato K, Kondo M, Sakuta K, Hosoi A, Noji S, Sugiura M, Yoshida Y, Kakimi K
  • Journal Title: Cytotherapy Pages: 1-11
  • Peer Reviewed
• [Journal Article] Impact of culture medium on the expression of T cells for immunotherapy. (2009)
  • Author(s): Sato K
  • Journal Title: Cytotherapy 11 Pages: 936-946
  • Peer Reviewed
• [Journal Article] がん特異的免疫療法の将来像 (2009)
  • Author(s): 國土典宏
  • Journal Title: Cancer Review(日経メディカル) Autumn Pages: 35-35
• [Journal Article] Zoledronate facilitates large-scale ex vivo expansion of functional gammadelta T cells from cancer patients for use in adoptive immunotherapy. (2008)
  • Author(s): Kondo M, Sakuta K, Noguchi A, Ariyoshi N, Sato K, Hosoi A, Nakajima J, Yoshida Y, Shiraishi K, Nakagawa K, Kakimi K
  • Journal Title: Cytotherapy 10(8) Pages: 842-856
  • Peer Reviewed
• [Journal Article] Zoledronate facilitates large-scale ex vivo expansion of functional ganmadelta T cells from cancer patients for use in adoptive immunotherapy. (2008)
  • Author(s): Kondo M
  • Journal Title: Cytotherapy 10 Pages: 842-856
  • Peer Reviewed
• [Journal Article] ポストゲノムのがん免疫細胞治療(今後の展開) (2008)
  • Author(s): 作田和子
  • Journal Title: 侵襲と免疫 17 Pages: 149-154
• [Journal Article] がんと免疫・免疫細胞治療について (2008)
  • Author(s): 垣見和宏
  • Journal Title: PHYSICIAN'S THERAPY MANUAL 6
• [Presentation] 膵癌術後補助療法としての全身化学療法・自己γδT細胞免疫治療併用療法 (2011)
  • Author(s): 青木琢,垣見和宏,國土典宏
  • Organizer: 第97回日本消化器病学会総会
  • Place of Presentation: 東京
• [Presentation] がんに対するγδT細胞治療 (2010)
  • Author(s): 泉謙道
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪市
  • Year and Date: 2010-09-24
• [Presentation] γδT細胞治療に用いるγδT糸田胞とその体内動態 (2010)
  • Author(s): 有吉直子
  • Organizer: 第14回日本がん免疫学会
  • Place of Presentation: 熊本市
  • Year and Date: 2010-07-23
• [Presentation] がんに対する免疫細胞治療～がんワクチンと細胞移入治療～ (2010)
  • Author(s): 垣見和宏
  • Organizer: 第19回日本癌病態治療研究会
  • Place of Presentation: 東京
  • Year and Date: 2010-06-30
• [Presentation] Adoptive γδT cell transfer for non-small cell lung cancer. (2010)
  • Author(s): 垣見和宏, et al.
  • Organizer: AACR 101^<st> Annual Meeting 2010
  • Place of Presentation: Washington DC, USA.
• [Presentation] がんに対する免疫細胞治療～がんワクチンと細胞移入療法～ (2010)
  • Author(s): 垣見和宏,他
  • Organizer: 第19回日本癌病態治療研究会
  • Place of Presentation: 東京
• [Presentation] Adoptive γδT cell transfer for non-small cell lung cancer. (2010)
  • Author(s): Kazuhiro Kakimi
  • Organizer: AACR 101st Annunal Meeting 2010
  • Place of Presentation: Washington, DC., USA
• [Presentation] Adoptive gamma/delta T cell for the treatment of cancer. (2010)
  • Author(s): Sakuta K
  • Organizer: 14th International Congress of Immunology
  • Place of Presentation: Kobe, Japan
• [Presentation] Cell therapy(細胞療法)の新たなアプローチ ゾレドロン酸を用いて培養したVγ9Vδ2T細胞による免疫細胞治療 (2009)
  • Author(s): 垣見和宏
  • Organizer: 第13回日本がん免疫学会総会
  • Place of Presentation: 北九州市
  • Year and Date: 2009-06-24
• [Presentation] Cell therapy(細胞療法)の新たなアプローチ:ゾレドロン酸を用いて培養したVγ9Vδ2T細胞による免疫細胞治療 (2009)
  • Author(s): 垣見和宏,他
  • Organizer: 第13回日本がん免疫学会総会
  • Place of Presentation: 北九州市
• [Presentation] ゾレドロン酸を用いて培養したVγ9Vδ2T細胞による免疫細胞治療 (2008)
  • Author(s): 近藤真
  • Organizer: 第12回基盤的癌免疫研究会総会
  • Place of Presentation: 大宮市
• [Remarks] ホームページ等
• [Remarks]
  • URL: http://www.h.u-tokyo.ac.jp/center22/meneki_saibou.html