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Combination adjuvant therapy using chemotherapy and immunotherapy for pancreatic cancer: assessment of safety and efficacy.

Research Project

Project/Area Number 20591623
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionThe University of Tokyo

Principal Investigator

AOKI Taku  The University of Tokyo, 医学部附属病院, 講師 (30302722)

Co-Investigator(Kenkyū-buntansha) HASEGAWA Kiyoshi  東京大学, 医学部附属病院, 准教授 (20292906)
KOKUDO Norihiro  東京大学, 医学部附属病院, 教授 (00205361)
KAKIMI Kazuhiro  東京大学, 医学部附属病院, 特任准教授 (80273358)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords膵臓外科学 / 化学療法 / 免疫療法 / 膵癌 / 補助化学療法
Research Abstract

An adjuvant therapy using combination of Gemcitabine and auto γδ T lymphocyte immunotherapy was conducted for postoperative patients with pancreatic cancer. Twenty-two patients were enrolled and actually 11 patients received the combination therapy. The safety of the therapy was confirmed, but the benefit for disease-free survival was unclear. Further follow-up will be needed.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (26 results)

All 2011 2010 2009 2008 Other

All Journal Article (13 results) (of which Peer Reviewed: 9 results) Presentation (11 results) Remarks (2 results)

  • [Journal Article] Adoptive immunotherapy for advanced non-small cell lung cancer using zoledronate-expanded γδT cells : a phase I clinical study.2011

    • Author(s)
      Sakamoto M, Nakajima J, Murakawa T, Fukami T, Yoshida Y, Murayama T, Takamoto S, Matsushita H, Kakimi K
    • Journal Title

      J Immunother 34(2)

      Pages: 202-211

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] A phase I study of adoptive immunotherapy for recurrent non-small cell lung cancer patients with autologous gammadelta T cells.2010

    • Author(s)
      Nakajima J, Murakawa T, Fukami T, Goto S, Kaneko T, Yoshida Y, Takamoto S, Kakimi K
    • Journal Title

      Eur j cardiothorac Surg 37(5)

      Pages: 1191-1197

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] A phase I study of adoptive immunotherapy for recurrent non-small-cell lung cancer patients with autologous gammadelta T cells2010

    • Author(s)
      Nakajima J
    • Journal Title

      Eur J Cardiothorac Surg

      Volume: 37 Pages: 1191-1197

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Adoptive immnotherapy for advanced non-small-cell lung cancer using zelodronate-expanded gammadelta T cells : a phase I clinical study.2010

    • Author(s)
      Sakamoto M
    • Journal Title

      J Immunother

      Volume: 34 Pages: 201-211

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A phase I study of adoptive immunotherapy for recurrent non-small-cell lung cancer patients with autologous gammadelta T cells.2010

    • Author(s)
      Nakajima J
    • Journal Title

      Eur J Cardiothorac Surg 3-Feb(in print)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] がん特異的免疫療法の将来像2009

    • Author(s)
      國土典宏
    • Journal Title

      Cancer Review(日経メディカル) 8月号

      Pages: 35-35

    • Related Report
      2010 Final Research Report
  • [Journal Article] Impact of culture medium on the expansion of T cells for immunotherapy.2009

    • Author(s)
      Sato K, Kondo M, Sakuta K, Hosoi A, Noji S, Sugiura M, Yoshida Y, Kakimi K
    • Journal Title

      Cytotherapy

      Pages: 1-11

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Impact of culture medium on the expression of T cells for immunotherapy.2009

    • Author(s)
      Sato K
    • Journal Title

      Cytotherapy 11

      Pages: 936-946

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] がん特異的免疫療法の将来像2009

    • Author(s)
      國土典宏
    • Journal Title

      Cancer Review(日経メディカル) Autumn

      Pages: 35-35

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Zoledronate facilitates large-scale ex vivo expansion of functional gammadelta T cells from cancer patients for use in adoptive immunotherapy.2008

    • Author(s)
      Kondo M, Sakuta K, Noguchi A, Ariyoshi N, Sato K, Hosoi A, Nakajima J, Yoshida Y, Shiraishi K, Nakagawa K, Kakimi K
    • Journal Title

      Cytotherapy 10(8)

      Pages: 842-856

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Zoledronate facilitates large-scale ex vivo expansion of functional ganmadelta T cells from cancer patients for use in adoptive immunotherapy.2008

    • Author(s)
      Kondo M
    • Journal Title

      Cytotherapy 10

      Pages: 842-856

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ポストゲノムのがん免疫細胞治療(今後の展開)2008

    • Author(s)
      作田和子
    • Journal Title

      侵襲と免疫 17

      Pages: 149-154

    • Related Report
      2008 Annual Research Report
  • [Journal Article] がんと免疫・免疫細胞治療について2008

    • Author(s)
      垣見和宏
    • Journal Title

      PHYSICIAN'S THERAPY MANUAL 6

    • Related Report
      2008 Annual Research Report
  • [Presentation] 膵癌術後補助療法としての全身化学療法・自己γδT細胞免疫治療併用療法2011

    • Author(s)
      青木琢,垣見和宏,國土典宏
    • Organizer
      第97回日本消化器病学会総会
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report
  • [Presentation] がんに対するγδT細胞治療2010

    • Author(s)
      泉謙道
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪市
    • Year and Date
      2010-09-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] γδT細胞治療に用いるγδT糸田胞とその体内動態2010

    • Author(s)
      有吉直子
    • Organizer
      第14回日本がん免疫学会
    • Place of Presentation
      熊本市
    • Year and Date
      2010-07-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] がんに対する免疫細胞治療~がんワクチンと細胞移入治療~2010

    • Author(s)
      垣見和宏
    • Organizer
      第19回日本癌病態治療研究会
    • Place of Presentation
      東京
    • Year and Date
      2010-06-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] Adoptive γδT cell transfer for non-small cell lung cancer.2010

    • Author(s)
      垣見和宏, et al.
    • Organizer
      AACR 101^<st> Annual Meeting 2010
    • Place of Presentation
      Washington DC, USA.
    • Related Report
      2010 Final Research Report
  • [Presentation] がんに対する免疫細胞治療~がんワクチンと細胞移入療法~2010

    • Author(s)
      垣見和宏,他
    • Organizer
      第19回日本癌病態治療研究会
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report
  • [Presentation] Adoptive γδT cell transfer for non-small cell lung cancer.2010

    • Author(s)
      Kazuhiro Kakimi
    • Organizer
      AACR 101st Annunal Meeting 2010
    • Place of Presentation
      Washington, DC., USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] Adoptive gamma/delta T cell for the treatment of cancer.2010

    • Author(s)
      Sakuta K
    • Organizer
      14th International Congress of Immunology
    • Place of Presentation
      Kobe, Japan
    • Related Report
      2010 Annual Research Report
  • [Presentation] Cell therapy(細胞療法)の新たなアプローチ ゾレドロン酸を用いて培養したVγ9Vδ2T細胞による免疫細胞治療2009

    • Author(s)
      垣見和宏
    • Organizer
      第13回日本がん免疫学会総会
    • Place of Presentation
      北九州市
    • Year and Date
      2009-06-24
    • Related Report
      2009 Annual Research Report
  • [Presentation] Cell therapy(細胞療法)の新たなアプローチ:ゾレドロン酸を用いて培養したVγ9Vδ2T細胞による免疫細胞治療2009

    • Author(s)
      垣見和宏,他
    • Organizer
      第13回日本がん免疫学会総会
    • Place of Presentation
      北九州市
    • Related Report
      2010 Final Research Report
  • [Presentation] ゾレドロン酸を用いて培養したVγ9Vδ2T細胞による免疫細胞治療2008

    • Author(s)
      近藤真
    • Organizer
      第12回基盤的癌免疫研究会総会
    • Place of Presentation
      大宮市
    • Related Report
      2008 Annual Research Report
  • [Remarks] ホームページ等

    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://www.h.u-tokyo.ac.jp/center22/meneki_saibou.html

    • Related Report
      2009 Annual Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

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