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Novel cancer related genes of lung based on the genomic and epigenomic aberrations.

Research Project

Project/Area Number 20591664
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Thoracic surgery
Research InstitutionTokyo Medical and Dental University

Principal Investigator

YOKOI Sana  Tokyo Medical and Dental University, がんゲノムセンター, 部長 (30372452)

Co-Investigator(Renkei-kenkyūsha) INAZAWA Johji  東京医科歯科大学, 難治疾患研究所, 教授 (30193551)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords肺がん / ゲノム / DNAコピー数 / 癌 / マイクロアレイ / 肺癌 / 遺伝子増幅 / エピゲノム / ホモ欠失 / メチル化 / 免疫沈降 / X染色体
Research Abstract

To explore novel lung cancer related genes, genomic and epigenomic aberrations were detected by DNA microarray in lung cancer cell lines and primary lung tumors from Japanese patients. We detected novel lung cancer related gene in the genomic amplified regions. We also make genetically modified mice of the gene.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (33 results)

All 2011 2010 2009 2008 Other

All Journal Article (15 results) (of which Peer Reviewed: 6 results) Presentation (18 results)

  • [Journal Article] Detection of Epithelial Growth Factor Receptor Mutations in Cerebrospinal Fluid from Patients with Lung Adenocarcinoma Suspected of Neoplastic Meningitis.2011

    • Author(s)
      Shingyoji M, Kageyama H, Sakaida T, Nakajima T, Matsui Y, Itakura M, Iuchi T, Yokoi S, Kimura H, Iizasa T
    • Journal Title

      J Thorac Oncol. (in press)

    • Related Report
      2010 Final Research Report
  • [Journal Article] Genome-wide DNA methylation profiles in renal tumors of various histological subtypes and non-tumorous renal tissues.2011

    • Author(s)
      Arai E, Wakai-Ushijima S, Fujimoto H, Hosoda F, Shibata T, Kondo T, Yokoi S, Imoto I, Inazawa J, Hirohashi S, Kanai Y
    • Journal Title

      Pathobiology. 78

      Pages: 1-9

    • Related Report
      2010 Final Research Report
  • [Journal Article] Diagnosis and prognostication of ductal adenocarcinomas of the pancreas based on genome-wide DNA methylation profiling by bacterial artificial chromosome array-based methylated CpG island amplification.2011

    • Author(s)
      Gotoh M, Arai E, Wakai-Ushijima S, Hiraoka N, Kosuge T, Hosoda F, Shibata T, Kondo T, Yokoi S, Imoto I, Inazawa J, Kanai Y
    • Journal Title

      J Biomed Biotechnol. 2011

      Pages: 780836-780836

    • Related Report
      2010 Final Research Report
  • [Journal Article] Copy number alterations in urothelial carcinomas : Their clinicopathological significance and correlation with DNA methylation alterations.2011

    • Author(s)
      Nishiyama N, Arai E, Nagashio R, Fujimoto H, Hosoda F, Shibata T, Tsukamoto T, Yokoi S, Imoto I, Inazawa J, Kanai Y
    • Journal Title

      Carcinogenesis. 32

      Pages: 462-9

    • Related Report
      2010 Final Research Report
  • [Journal Article] Genome-wide DNA methylation profiles in renal tumors of various histological subtypes and non-tumorous renal tissues.2011

    • Author(s)
      Arai E
    • Journal Title

      Pathobiology

      Volume: 78 Pages: 1-9

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diagnosis and prognostication of ductal adenocarcinomas of the pancreas based on genome-wide DNA methylation profiling by bacterial artificial chromosome array-based methylated CpG island amplification.2011

    • Author(s)
      Gotoh M
    • Journal Title

      J Biomed Biotechnol

      Volume: 201 Pages: 780836-780836

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Copy number alterations in urothelial carcinomas : Their clinicopathological significance and correlation with DNA methylation alterations.2011

    • Author(s)
      Nishiyama N
    • Journal Title

      Carcinogenesis

      Volume: 32 Pages: 462-469

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genome-wide DNA methylation profiles in urothelial carcinomas and urothelia at the precancerous stage.2010

    • Author(s)
      Nishiyama N, Arai E, Chihara Y, Fujimoto H, Hosoda F, Shibata T, Kondo T, Tsukamoto T, Yokoi S, Imoto I, Inazawa J, Hirohashi S, Kanai Y
    • Journal Title

      Cancer Sci. 101

      Pages: 231-240

    • NAID

      10027200383

    • Related Report
      2010 Final Research Report
  • [Journal Article] Genome-wide DNA methylation profiles in urothelial carcinomas and urothelia at the precancerous stage2010

    • Author(s)
      Nishiyama N
    • Journal Title

      Cancer Sci. 101

      Pages: 231-240

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genome-wide DNA methylation profiles in liver tissue at the precancerous stage and in hepatocellular carcinoma.2009

    • Author(s)
      Arai E, Ushijima S, Gotoh M, Ojima H, Kosuge T, Hosoda F, Shibata T, Kondo T, Yokoi S, Imoto I, Inazawa J, Hirohashi S, Kanai Y
    • Journal Title

      Int J Cancer. 125

      Pages: 2854-2862

    • Related Report
      2010 Final Research Report
  • [Journal Article] Genome-wide DNA methylation profiles in both precancerous conditions and clear cell renal cell carcinomas are correlated with malignant potential and patient outcome.2009

    • Author(s)
      Arai E., Ushijima S., Fujimoto H., Hosoda F., Shibata T., Kondo T., Yokoi S, Imoto I, Inazawa J, Hirohashi S, Kanai Y
    • Journal Title

      Carcinogenesis. 30

      Pages: 214-21

    • Related Report
      2010 Final Research Report
  • [Journal Article] Genome-wide DNA methylation profiles in liver tissue at the precancerous stage and in hepatocellular carcinoma2009

    • Author(s)
      Arai E
    • Journal Title

      Int J Cancer. 125

      Pages: 2854-2862

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genome-wide DNA methylation profiles in both precancerousconditions and clear cell renal cell carcinomas are correlatedwith malignant potential and patient outcome2009

    • Author(s)
      Arai E
    • Journal Title

      Carcinogenesis 30

      Pages: 214-221

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 遺伝子異常の全ゲノム探索2008

    • Author(s)
      横井左奈、稲澤譲治
    • Journal Title

      肺癌 66

      Pages: 45-49

    • Related Report
      2010 Final Research Report
  • [Journal Article] 遺伝子異常の全ゲノム探索2008

    • Author(s)
      横井左奈
    • Journal Title

      日本臨林 増刊 肺癌 66

      Pages: 45-49

    • Related Report
      2008 Annual Research Report
  • [Presentation] 癌性髄膜炎が疑われた肺癌症例における髄液中EGFR変異の検討2010

    • Author(s)
      新行内雅斗
    • Organizer
      第51回日本肺癌学会総会
    • Place of Presentation
      広島
    • Related Report
      2010 Final Research Report
  • [Presentation] バンクーバー2010

    • Author(s)
      CHEST
    • Place of Presentation
      カナダ
    • Related Report
      2010 Final Research Report
  • [Presentation] EGFR, K-ras, p53 gene mutation analysis in NSCLC using microsamples obtained by EBUS-TBNA2010

    • Author(s)
      Nakajima T
    • Organizer
      CHEST
    • Place of Presentation
      バンクーバー、カナダ
    • Related Report
      2010 Annual Research Report
  • [Presentation] The tripartite motif 33 (TRIM33), an amplification target for 1p13, promoted growth of breast cancer2009

    • Author(s)
      横井左奈
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-02
    • Related Report
      2010 Final Research Report
  • [Presentation] Genome-wide DNA methylation profiles in urothelial carcinomas and urothelia at the precancerous stage2009

    • Author(s)
      西山直隆
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-02
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] Genome-wide DNA methylation profiles in liver tissue at the precancerous stage and in hepatocellular carcinoma2009

    • Author(s)
      新井恵吏
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-02
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] The tripartite motif 33(TRIM33), an amplification target for 1p13, promoted growth of breast cancer2009

    • Author(s)
      横井左奈
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-02
    • Related Report
      2009 Annual Research Report
  • [Presentation] 1p13増幅領域の標的遺伝子tripartite motif 33(TRIM33)は乳癌の予後不良因子である2009

    • Author(s)
      横井左奈
    • Organizer
      日本人類遺伝学会第54回大会
    • Place of Presentation
      東京
    • Year and Date
      2009-09-25
    • Related Report
      2010 Final Research Report
  • [Presentation] 1p13増幅領域の標的遺伝子 tripartite motif 33(TRIM33)は乳癌の予後不良因子である2009

    • Author(s)
      横井左奈
    • Organizer
      日本人類遺伝学会 第54回大会
    • Place of Presentation
      東京
    • Year and Date
      2009-09-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] The tripartite motif 33 (TRIM33) gene is probable target for 1p13 amplification in small cell lung cancer2008

    • Author(s)
      横井左奈
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-28
    • Related Report
      2010 Final Research Report
  • [Presentation] X-tiling アレイを用いたX染色体上の癌関連遺伝子群の探索2008

    • Author(s)
      坂本宙子
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-28
    • Related Report
      2010 Final Research Report
  • [Presentation] The tripartite motif 33 (TRIM33)gene is probable target forlpl3 amplification in small cell lung cancer2008

    • Author(s)
      横井左奈
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] X-tilingアレイを用いたX染色体上の癌関連遺伝子群の探索2008

    • Author(s)
      坂本宙子
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] アレイCGH 法による肺小細胞癌の潜在的ゲノムコピー数解析と癌関連遺伝子の同定2008

    • Author(s)
      横井左奈
    • Organizer
      日本人類遺伝学会第53回大会
    • Place of Presentation
      横浜
    • Year and Date
      2008-09-29
    • Related Report
      2010 Final Research Report
  • [Presentation] アレイCGH法による肺小細胞癌の潜在的ゲノムコピー数解析と癌関連遺伝子の同定2008

    • Author(s)
      横井左奈
    • Organizer
      日本人類遺伝学会 第53回大会
    • Place of Presentation
      横浜
    • Year and Date
      2008-09-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] レット症候群の自閉症状の要因としてのシナプス関連分子のエピジェネテックな制御異常2008

    • Author(s)
      久保田健夫
    • Organizer
      第31回日本神経科学大会
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report
  • [Presentation] レッド症候群の自閉症状の要因としてのシナプス関連分子の工ピジェネテックな制御異常2008

    • Author(s)
      久保田健夫
    • Organizer
      第31回日本神経科学大会
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report
  • [Presentation] EGFR, K-ras, p53 gene mutation analysis in NSCLC using microsamples obtained by EBUS-TBNA

    • Author(s)
      Nakajima T
    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2023-01-13  

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