Novel cancer related genes of lung based on the genomic and epigenomic aberrations.
| Project/Area Number |
20591664
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
YOKOI Sana Tokyo Medical and Dental University, がんゲノムセンター, 部長 (30372452)
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| Co-Investigator(Renkei-kenkyūsha) |
INAZAWA Johji 東京医科歯科大学, 難治疾患研究所, 教授 (30193551)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 肺がん / ゲノム / DNAコピー数 / 癌 / マイクロアレイ / 肺癌 / 遺伝子増幅 / エピゲノム / ホモ欠失 / メチル化 / 免疫沈降 / X染色体 |
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| Research Abstract |
To explore novel lung cancer related genes, genomic and epigenomic aberrations were detected by DNA microarray in lung cancer cell lines and primary lung tumors from Japanese patients. We detected novel lung cancer related gene in the genomic amplified regions. We also make genetically modified mice of the gene.
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Report
(4 results)
Research Products
(33 results)
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[Journal Article] Genome-wide DNA methylation profiles in renal tumors of various histological subtypes and non-tumorous renal tissues.2011
Author(s)
Arai E, Wakai-Ushijima S, Fujimoto H, Hosoda F, Shibata T, Kondo T, Yokoi S, Imoto I, Inazawa J, Hirohashi S, Kanai Y
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Journal Title
Pathobiology. 78
Pages: 1-9
Related Report
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[Journal Article] Diagnosis and prognostication of ductal adenocarcinomas of the pancreas based on genome-wide DNA methylation profiling by bacterial artificial chromosome array-based methylated CpG island amplification.2011
Author(s)
Gotoh M, Arai E, Wakai-Ushijima S, Hiraoka N, Kosuge T, Hosoda F, Shibata T, Kondo T, Yokoi S, Imoto I, Inazawa J, Kanai Y
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Journal Title
J Biomed Biotechnol. 2011
Pages: 780836-780836
Related Report
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[Journal Article] Copy number alterations in urothelial carcinomas : Their clinicopathological significance and correlation with DNA methylation alterations.2011
Author(s)
Nishiyama N, Arai E, Nagashio R, Fujimoto H, Hosoda F, Shibata T, Tsukamoto T, Yokoi S, Imoto I, Inazawa J, Kanai Y
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Journal Title
Carcinogenesis. 32
Pages: 462-9
Related Report
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[Journal Article] Genome-wide DNA methylation profiles in urothelial carcinomas and urothelia at the precancerous stage.2010
Author(s)
Nishiyama N, Arai E, Chihara Y, Fujimoto H, Hosoda F, Shibata T, Kondo T, Tsukamoto T, Yokoi S, Imoto I, Inazawa J, Hirohashi S, Kanai Y
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Journal Title
Cancer Sci. 101
Pages: 231-240
NAID
Related Report
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[Journal Article] Genome-wide DNA methylation profiles in liver tissue at the precancerous stage and in hepatocellular carcinoma.2009
Author(s)
Arai E, Ushijima S, Gotoh M, Ojima H, Kosuge T, Hosoda F, Shibata T, Kondo T, Yokoi S, Imoto I, Inazawa J, Hirohashi S, Kanai Y
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Journal Title
Int J Cancer. 125
Pages: 2854-2862
Related Report
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[Journal Article] Genome-wide DNA methylation profiles in both precancerous conditions and clear cell renal cell carcinomas are correlated with malignant potential and patient outcome.2009
Author(s)
Arai E., Ushijima S., Fujimoto H., Hosoda F., Shibata T., Kondo T., Yokoi S, Imoto I, Inazawa J, Hirohashi S, Kanai Y
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Journal Title
Carcinogenesis. 30
Pages: 214-21
Related Report
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