The project of glioma cell absorption therapy using proteoglycan and molecular targeting therapy
| Project/Area Number |
20591702
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Hirosaki University |
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Principal Investigator |
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | プロティオグリカン / AG1478 / カドヘリン / EGFR / 人工基質 / 悪性グリオーマ |
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| Research Abstract |
My main project is to prevent the tumor cell invasion. And it is very convenient if tumor cell might migrate to only one portion. By using this way, we would treat the remained tumor cell effectively.
My final goal is to product the experimental model of glioma cell absorption model using proteoglycan and molecular targeting therapy after tumor removal operation.
In vitro experiment, I confirmed the effectiveness of C6-GFP cell absorption 2 times higher than artificial basement layer without proteoglycan. And also, most effective concentration is 10nmol/ml of AG1478 and 50mg/ml of proteoglycan.
In vivo experiment, same data of absorption of C6-GFP and the remain in the rat intracereber cortex were confirmed. I also confirmed that C6-GFP tumor cell which had invaded in a brain was carry out to the artificial matrix with proteoglycans.
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Report
(4 results)
Research Products
(11 results)
