| Project/Area Number |
20591743
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Hiroshima University |
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Principal Investigator |
TANAKA Nobuhiho Hiroshima University, 病院, 助教 (20363062)
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| Co-Investigator(Kenkyū-buntansha) |
NAKANISHI Kazuyoshi 広島大学, 病院, 病院助教 (60403557)
OCHI Mitsuo 広島大学, 病院, 教授 (70177244)
MOCHIZUKI Yu 広島大学, 大学院・医歯薬学総合研究科, 准教授 (10284192)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 老化 / 椎間板変性 / 酸化ストレス |
|---|
| Research Abstract |
We studied to repress the progression of intervertebral disc degeneration using intervertebral disc degeneration model of Bach1deficient mice, which highly express Heme oxygenase-1 (HO-1) that is anti- oxidant material. To compared with Wild type mice, the histological progression of intevertebral disc degeneration was repressed in Bach1 deficient mice, and they highly expressed HO-1. The result showed that inhibiting oxidative stress can repress the progression of intervertebral disc degeneration, and new therapeutic method to intervertebral disc degeneration.
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