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Antiaging of intervertebral disc by controlling oxidative stress

Research Project

Project/Area Number 20591743
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthopaedic surgery
Research InstitutionHiroshima University

Principal Investigator

TANAKA Nobuhiho  Hiroshima University, 病院, 助教 (20363062)

Co-Investigator(Kenkyū-buntansha) NAKANISHI Kazuyoshi  広島大学, 病院, 病院助教 (60403557)
OCHI Mitsuo  広島大学, 病院, 教授 (70177244)
MOCHIZUKI Yu  広島大学, 大学院・医歯薬学総合研究科, 准教授 (10284192)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords老化 / 椎間板変性 / 酸化ストレス
Research Abstract

We studied to repress the progression of intervertebral disc degeneration using intervertebral disc degeneration model of Bach1deficient mice, which highly express Heme oxygenase-1 (HO-1) that is anti- oxidant material. To compared with Wild type mice, the histological progression of intevertebral disc degeneration was repressed in Bach1 deficient mice, and they highly expressed HO-1. The result showed that inhibiting oxidative stress can repress the progression of intervertebral disc degeneration, and new therapeutic method to intervertebral disc degeneration.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (4 results)

All 2011 2010

All Presentation (4 results)

  • [Presentation] Heme oxygenase-1 modulates degeneration of the intervertebral disc in Bach 1 deficient mice2011

    • Author(s)
      大田亮
    • Organizer
      2011 Orthopaedic Research Society Annual Meeting
    • Place of Presentation
      Long Beach U.S.A
    • Related Report
      2010 Final Research Report
  • [Presentation] Heme oxygenase-1 modulates degeneration of the intervertebral disc in Bach1 deficient mice.2011

    • Author(s)
      大田亮
    • Organizer
      2011 Orthopaedic Research Society Annual Meeting
    • Place of Presentation
      Long Beach, California, USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] Bach1ノックアウトマウスにおける抗酸化ストレスによる椎間板変性抑制効果2010

    • Author(s)
      大田亮
    • Organizer
      第47回広島脊椎脊髄セミナー
    • Place of Presentation
      広島市
    • Year and Date
      2010-11-27
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] Bach1ノックアウトマウスにおいてHeme oxygenase-1は椎間板変性を調整する2010

    • Author(s)
      大田亮
    • Organizer
      第25回日本整形外科学会基礎学術集会
    • Place of Presentation
      京都市
    • Year and Date
      2010-10-15
    • Related Report
      2010 Annual Research Report 2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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