| Project/Area Number |
20591761
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Nagasaki University |
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Principal Investigator |
KOSEKI Hironobu (2009-2010) Nagasaki University, 医歯薬学総合研究科, 客員研究員 (70457571)
榎本 寛 (2008) Nagasaki University, 大学院・医歯薬学総合研究科, 助教 (90284679)
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| Co-Investigator(Kenkyū-buntansha) |
弦本 敏行 長崎大学, 大学院・医歯薬学総合研究科, 教授 (60304937)
進藤 裕幸 長崎大学, 大学院・医歯薬学総合研究科, 教授 (30107677)
小関 弘展 長崎大学, 医学部・歯学部附属病院, 客員研究員 (70457571)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 生体材料 / 細菌 / 感染症 / 酸化チタン / 酸化チタン(TiO_2) / 光触媒 / 薄膜 / 超微粒子 / 微粒子 / 黄色ブドウ球菌 |
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| Research Abstract |
Basic research and animal studies were conducted on the bactericidal effect of photocatalytic titanium dioxide (TiO2) against infectious diseases caused by microorganisms (particularly intraoperative infections). Effective bactericidal effects against various staphylococci were observed when a TiO2 film was applied to metal surfaces used during surgery and when an aqueous solution of ultrafine TiO2 particles was used. There was no evidence suggesting toxicity or harmful effects on living cells or tissues. The TiO2 developed in this research has the potential for use as a therapeutic method to help patients suffering from various infectious diseases.
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