New mechanisms of regulation of longitudinal growth of tubular bone

• Project/Area Number: 20591782
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: The University of Tokushima
• Principal Investigator: TAKATA Shinjiro The University of Tokushima, 病院, 准教授 (20284292)
• Co-Investigator(Kenkyū-buntansha): YASUI Natsuo 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (00157984) ; TAKAHASHI Mitsuhiko 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助教 (10372715) ; ENISHI TETSUYA 徳島大学, 病院, 医員 (20467806)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 骨軟骨代謝学 / 長管骨 / 骨膜 / 膜性骨化 / 内軟骨性骨化 / 破骨細胞 / 骨形態計測 / 骨膜切除 / μCT / 骨代謝 / 長径成長

Research Abstract

Circumferential periosteal division (CPD) of diaphysis of femur of rat aged 8 weeks produces longitudinal overgrowth. Periosteum of diaphysis of the right femur was divided circumferentially (CPD group), and the left femur was control (Control group). Bone histomorphometry analysis revealed that CPD stimulates endochondral ossification of CPD group compared with Control group. Three-dimensional microstructure analysis of trabecular bone by μCT system showed that CPD increased number of trabecular bone compared with Control group. These results suggest that periosteum regulates endochondral ossification of tubular bone.

Research Products

• [Journal Article] Efficacy, tolerability and safety of risedronate in Japanese patients with Paget's disease of bone. (2010)
  • Author(s): Yoh K, Takata S, Yoshimura N, Hashimoto J
  • Journal Title: J Bone Miner Metab 28 Pages: 468-476
  • NAID: 10027208413
  • Peer Reviewed
• [Journal Article] Relationship between Barthel Index scores and ADL in stroke patients during acute phase of rehabilitation. (2010)
  • Author(s): Nakao S, Takata S, Uemura H, Kashihara M, Osawa T, Komatsu K, Masuda Y, Okahisa T, Nishikawa K, Kondo S, Yamada M, Takahara R, Ogata Y, Nakamura Y, Yasui N
  • Journal Title: J Med Invest 57(1,2) Pages: 81-88
  • Peer Reviewed
• [Journal Article] Early ambulation after total knee arthroplasty prevents patients with osteoarthritis and rheumatoid arthritis from developing deep venous thrombosis. (2010)
  • Author(s): Nakao S, Takata S, Uemura H, Nakano S, Egawa H, Kawasaki Y, Yasui N
  • Journal Title: J Med Invest 57(1,2) Pages: 146-151
  • Peer Reviewed
• [Journal Article] Nonunion of capital femoral physeal fracture with a large metaphyseal fragment. (2010)
  • Author(s): Yukata K, Kubo T, Matsui Y, Koizumi T, Takata S, Yasui N
  • Journal Title: J Orthop Trauma 24(8)
  • Peer Reviewed
• [Journal Article] Efficacy, tolerability and safety of risedronate in Japanese patients with Paget's disease of bone. (2010)
  • Author(s): Kosei Yoh
  • Journal Title: J Bone Miner Metab Volume: 28 Pages: 468-476
  • Peer Reviewed
• [Journal Article] Relationship between Barthel Index scores and ADL in stroke patients during acute phase of rehabilitation. (2010)
  • Author(s): Shigetaka Nakao
  • Journal Title: Journal of Medical Investigation Volume: 57 Pages: 81-88
  • Peer Reviewed
• [Journal Article] Early ambulation after total knee arthroplasty prevents patients with osteoarthritis and rheumatoid arthritis from developing deep venous thrombosis. (2010)
  • Author(s): Shigetaka Nakao
  • Journal Title: Journal of Medical Investigation Volume: 57 Pages: 146-151
  • Peer Reviewed
• [Journal Article] Relationship between Barthel index scores and ADL in stroke patients during acute phase of rehabilitation. (2010)
  • Author(s): Nakao S, et al.
  • Journal Title: Journal of Medical Investigation 57 Pages: 81-88
  • Peer Reviewed
• [Journal Article] Optimal increase in bone mass by continuous local infusion of alendronate during distraction osteogenesis in rabbits. (2009)
  • Author(s): Abbaspour A, Takahashi M, Sairyo K, Takata S, Yukata K, Inui A, Yasui N
  • Journal Title: Bone 44(5) Pages: 917-923
  • Peer Reviewed
• [Journal Article] The effect of rheumatoid arthritis on the anatomy of the female cervical spine : a radiographical study. (2009)
  • Author(s): Higashino K, Sairyo K, Katoh S, Nakano S, nishi T, yasui N
  • Journal Title: J Bone Joint Surg 91(8) Pages: 1058-1063
  • Peer Reviewed
• [Journal Article] Percutaneous opening wedge varus osteotomy with a multidrilling guide in Perthes' disease : a technical note on two cases. (2009)
  • Author(s): Kawasaki Y, Hanaoka N, Takahashi M, Egawa H, Yasui N
  • Journal Title: J Pediatr Orthop B 18(5) Pages: 242-247
  • Peer Reviewed
• [Journal Article] Intramedullary schwanomma with calcification of the epiconus. (2009)
  • Author(s): Hayashi F, Sakai T, Sairyo K, Hirohashi N, Higashino K, Katoh S, Yasui N
  • Journal Title: Spine J 9(5)
  • Peer Reviewed
• [Journal Article] Optimal increase in bone mass by continuous local infusion of alendronate during distraction osteogenesis in rabbits. (2009)
  • Author(s): Abbaspour A, et al.
  • Journal Title: Bone Vol.44 Pages: 917-923
  • Peer Reviewed
• [Journal Article] Efficacy, tolerability and safety of risedronate in Japanese patients with Paget's disease of bone. (2009)
  • Author(s): Yoh K, et al.
  • Journal Title: Journal of Bone and Mineral Metabolism (Epub ahead of print)
  • Peer Reviewed
• [Journal Article] Continuous infusion of insulin-like growth factor-I (IGF-I) into the epiphysis promotes longitudinal bone growth of the tibiae in young rabbits. (2008)
  • Author(s): Abbaspour A, Takata S, Matsui Y, Katoh S, Takahashi M, Yasui N
  • Journal Title: Int Orthop 32(3) Pages: 395-402
  • Peer Reviewed
• [Journal Article] Continuous local infusion of fibroblast growth factor-2 enhances consolidation of the bone segment lengthened by distraction osteogenesis in rabbit experiment. (2008)
  • Author(s): Abbaspour A, Takata S, Sairyo K, Kato S, Yukata K, Yasui N
  • Journal Title: Bone 42(1) Pages: 98-106
  • Peer Reviewed
• [Journal Article] Therapeutic effects of one-year alendronate treatment in three cases of osteoporosis with parietal thinning of skull. (2008)
  • Author(s): Takata S, Takao S, Yoshida S, Yasui N
  • Journal Title: J Med Invest 55(3,4) Pages: 297-302
  • NAID: 130004465157
  • Peer Reviewed
• [Journal Article] Continuous infusion of insulin-like growth factor-I (IGF-I) into the epiphysis promotes longitudinal bone growth of the tibiae in young rabbits. (2008)
  • Author(s): 高田信二郎
  • Journal Title: Int Orthop 32(3) Pages: 395-402
  • Peer Reviewed
• [Journal Article] Continuous local infusion of fibroblast growth factor-2 enhances consolidation of the bone segment lengthened by distraction osteogenesis in rabbit experiment. (2008)
  • Author(s): 高田信二郎
  • Journal Title: Bone 42(1) Pages: 98-106
  • Peer Reviewed
• [Journal Article] Therapeutic effects of one-year alendronate treatment in three cases of osteoporosis with parietal thinning of skull. (2008)
  • Author(s): 高田信二郎
  • Journal Title: J Med Invest 55(3, 4) Pages: 297-302
  • NAID: 130004465157
  • Peer Reviewed
• [Presentation] Circumferential periosteal stripping of femoral diaphysis of developing rat produces longitudinal overgrowth and cortical hypertrophy. (2010)
  • Author(s): 高田信二郎, 他
  • Organizer: 32^<nd> Annual Meeting for American Society of Bone Mineral Research.
  • Place of Presentation: Toronto, Canada
• [Presentation] ラット大腿骨骨幹部の全周性骨膜切除は内軟骨性骨化と膜性骨化とを促進する (2010)
  • Author(s): 高田信二郎, 他
  • Organizer: 第28回日本骨代謝学会
  • Place of Presentation: 東京都
• [Presentation] シンポジウムリハビリテ-ション医学領域の基礎研究と臨床応用.骨関節領域の基礎研究 (2010)
  • Author(s): 高田信二郎
  • Organizer: 第47回日本リハビリテーション医学会学術集会
  • Place of Presentation: 鹿児島市
• [Presentation] 成長期ラット大腿骨骨幹部の全周性骨膜切除が内軟骨性骨化と膜性骨化に及ぼす影響 (2010)
  • Author(s): 高田信二郎, 他
  • Organizer: 第30回日本骨形態計測学会
  • Place of Presentation: 米子市
• [Presentation] Circumferential periosteal stripping of femoral diaphysis of developing rat produces duces longitudinal overgrowth and cortical hypertrophy (2010)
  • Author(s): Shinjiro Takata
  • Organizer: 32nd Annual Meeting of American Society of Bone and Mineral Research
  • Place of Presentation: Toronto, Canada
• [Presentation] Unilateral circumferential periosteal removal causes overgrowth of rat femur by activation of endochondral ossification of growth plate. (2009)
  • Author(s): 高田信二郎, 他
  • Organizer: 31^<st> Annual Meeting of American Society for Bone Mineral Research.
  • Place of Presentation: Denver, Colorado, USA.
• [Presentation] ラット大腿骨骨幹部の骨膜切除は成長軟骨板における内軟骨性骨化を活性化して骨を延長する (2009)
  • Author(s): 高田信二郎, 他
  • Organizer: 第24回日本整形外科学会基礎学術集会
  • Place of Presentation: 横浜市
• [Presentation] ラット大腿骨骨幹部骨膜の全周性切除が長径成長と骨微細構造におよぼす影響 (2009)
  • Author(s): 高田信二郎, 江西哲也, 他
  • Organizer: 第11回日本骨粗鬆症学会
  • Place of Presentation: 名古屋市
• [Presentation] ラット大腿骨骨幹部の骨膜切除がその長径成長におよぼす影響 (2009)
  • Author(s): 高田信二郎, 他
  • Organizer: 第46回日本リハビリテーション医学会学術集会
  • Place of Presentation: 静岡市
• [Presentation] 長管骨骨幹部の骨膜切除による長径成長促進と骨形態変化の機序解明 (2009)
  • Author(s): 高田信二郎, 他
  • Organizer: 第29回日本骨形態計測学会
  • Place of Presentation: 大阪市
• [Presentation] Circumferential periosteal removal causes overgrowth of rat femur by Activation of endochondral ossification of growth plate. (2009)
  • Author(s): Takata S, et al.
  • Organizer: 31th Annual Meeting of American Society of Bone and Mineral Research
  • Place of Presentation: Colorado Convention Center(Denver)
• [Presentation] Therapeutic effects of one-year alendronate treatment in three cases of osteoporosis with parietal thinning. (2008)
  • Author(s): 高田信二郎, 他
  • Organizer: 30^<th> Annual Meeting of American Society for Bone Mineral Research. Montrea, Quebec, Canada
  • Place of Presentation: Canada.
• [Presentation] Continuous local infusion of alendronate prevents osteopenia of the lengthened segment during distraction osteogenesis. (2008)
  • Author(s): 高田信二郎
  • Organizer: The American Society of Bone and Mineral Research (ASBMR) 30th Annual Meeting
  • Place of Presentation: Montreal, Canada
• [Presentation] Therapeutic effects of one-year Alendronate treatment in three cases of osteoporosis with parietal thinning. (2008)
  • Author(s): 高田信二郎
  • Organizer: The American Society of Bone and Mineral Research (ASBMR) 30th Annual Meeting
  • Place of Presentation: Montreal, Canada
• [Presentation] ラット大腿骨骨幹部の骨膜切除がその長径成長と骨密度に及ぼす影響. (2008)
  • Author(s): 高田信二郎
  • Organizer: 第23回日本整形外科学会基礎学術集会.
  • Place of Presentation: 京都市
• [Presentation] 脛骨骨端部骨髄腔へのinsulin-like growth factor-Iの持続注入の効果. (2008)
  • Author(s): 高田信二郎
  • Organizer: 第23回日本整形外科学会基礎学術集会.
  • Place of Presentation: 京都市
• [Presentation] Fibroblast growth factor-2、Alendronateの局所持続投与はウサギ仮骨延長の骨癒合を促進する. (2008)
  • Author(s): 高田信二郎
  • Organizer: 第23回日本整形外科学会基礎学術集会.
  • Place of Presentation: Montreal, Canada
• [Book] リウマチ科 (2008)
  • Author(s): 高田信二郎
  • Total Pages: 5
  • Publisher: 骨Paget病およびその関連疾患と骨代謝関連分子の遺伝子異常.