| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Research Abstract |
In order to elucidate the pathogenesis of inflammatory diseases such as rheumatoid arthritis (RA), it is important to understand the mechanism of regulating T cell functions that play central role in immune responses. In the present study, we addressed the role of IL-15, one of the proinflammatory cytokines that are upregulated in RA, in T cell functions in vivo by using mouse models. We found IL-15 is especially important in the development, maintenance, and activation of self-specific T cells.
|
